la consommation d’alcool faible ou modérée est associée à une augmentation du volume hippocampique (l’hippocampe de la maladie d’Alzheimer est l’une des premières régions du cerveau à subir des dommages. Les problèmes de mémoire et de désorientation apparaissent parmi les premiers symptômes.
Les dommages à l’hippocampe peut également provenir de situations de manque d’oxygène (hypoxie), l’inflammation du cerveau (encéphalite) ou l’épilepsie du lobe temporal. Les personnes qui ont subi des dommages importants dans l’hippocampe peuvent éprouver l’incapacité d’acquérir ou de conserver de nouveaux souvenirs (amnésie), une diminution de l’intensité de la douleur clinique et une meilleure qualité du sommeil chez les patients atteints de fibromyalgie, selon une nouvelle étude.
L’étude « consommation faible à modérée d’alcool est associée à la fibromyalgie dans le volume hippocampique et l’ insomnie , » a été publiée dans Behavioral Sleep Medicine.
Les patients souffrant de fibromyalgie rapportent souvent des troubles de la fatigue et le sommeil. En fait, une étude a montré que 75% des patients atteints de fibromyalgie ont des symptômes d’insomnie chronique.
La fibromyalgie et l’ insomnie chronique se produisent souvent ensemble, et les deux sont associés à une sensibilité accrue à la douleur, ce qui peut être lié à l’hippocampe, comme il est impliqué dans des stimuli de douleur.
Des études ont montré que le volume hippocampique est réduite chez les patients atteints de fibromyalgie, ainsi que chez les patients souffrant d’insomnie chronique.
Cependant, aucune étude n’a démontré l’impact de la structure de l’hippocampe chez les patients souffrant à la fois la douleur musculo – squelettique chronique et l’ insomnie chronique.
La consommation d’alcool est d’un grand intérêt dans ce domaine, car il effectue un certain nombre d’activités intéressantes en raison de leurs nombreuses interactions avec une variété de systèmes de neurotransmetteurs tels que l’inhibition de la gamma aminobutyrique (acide butyrique) et NMDA ( N-méthyl D-aspartate).
Patients atteints de fibromyalgie ont des niveaux élevés d’acides aminés excitateurs agissant sur les récepteurs NMDA, qui sont associés à une hyperalgésie (sensibilité accrue à la douleur) et l’ allodynie (douleur de réponse à un stimulus qui ne provoque généralement pas de douleur).
Il a été démontré que l’ inhibition des récepteurs de GABA favorise le sommeil et réduit l’ anxiété.
Par conséquent, les chercheurs pourraient supposer que l’ alcool pourrait aider à réguler les symptômes de la fibromyalgie et l’ insomnie par l’ inhibition des récepteurs NMDA et GABA.
Des chercheurs de l’Université de Floride ont étudié si la consommation d’alcool chez les patients atteints de fibromyalgie avec et sans l’ insomnie chronique est associée à des différences dans la structure de la résonance magnétique hippocampe.
Ils ont également évalué l’effet de l’ alcool sur une série de mesures liées à la douleur et le sommeil.
Quarante et un patients souffrant de fibromyalgie, dont 19 avaient l’ insomnie, ont été invités à remplir un journal quotidien avec plusieurs paramètres liés à cette étude, y compris le sommeil, la douleur et l’ alcool boisson quantité pendant 14 jours.
Cela a été suivi d’une IRM structurelle pour déterminer le volume de l’hippocampe.
Fait intéressant, l’IRM a montré que le volume le plus avait hippocampique bilatérale (les deux côtés) chez les buveurs modérés par rapport aux patients qui se sont abstenus, qui n’a pas été signalé auparavant.
L’étude suggère que les buveurs modérés ont connu moins de douleur clinique et un meilleur sommeil de qualité.
Cependant, il n’y avait pas de corrélation significative entre le volume hippocampique et le sommeil ou des mesures liées à la douleur.
Par conséquent, l’ alcool peut aider les symptômes de fibromyalgie en agissant sur plusieurs niveaux, plutôt que dans l’hippocampe seul.
« Les personnes atteintes de fibromyalgie seule, ou la fibromyalgie et l’ insomnie chronique, avec une faible consommation d’alcool modérée symptômes signalés moins de douleur, et avait un hippocampe significativement plus élevé que les abstinents , » écrivent les auteurs.
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