Syndrome de fatigue chronique? Ce n’est pas toi, c’est ton système immunitaire

Cette maladie provoque une fatigue extrême et pourrait être activée par la réponse exagérée de votre système.

Une réponse exagérée du système immunitaire peut déclencher une étrange condition qui provoque une fatigue extrême,  a révélé une nouvelle étude publiée lundi.

Selon  les  informations de CNN , le   syndrome de fatigue chronique,  une condition qui provoque une fatigue extrême,  pourrait être déclenché par un système immunitaire hyperactif,   selon l’étude.

Des chercheurs au Royaume –  Uni ont  découvert que  la réponse immunitaire exagérée qui peut déclencher la fatigue,  suggérant que c’est ainsi que commence une maladie appelée  encéphalomyélite myalgique ou ME.

La chercheuse principale Carmine Pariante, professeur de psychiatrie biologique au King’s College de Londres, a déclaré que c’était la première étude à aborder le  «rôle du système immunitaire dans le développement de la maladie, un trouble multisystémique dont on sait peu de choses  . 

Pariante a expliqué que , dans  de nombreux cas de fatigue chronique, les patients se rappellent une infection, comme  un rhume très mauvaise ou une autre infection virale,  dans  les premiers stades de développement de la maladie.

Pour essayer d’en savoir plus, l’équipe a modélisé une voie possible vers la condition basée sur le traitement des infections chroniques à l’  hépatite C  , appelée interféron alpha, car le traitement est connu pour induire une fatigue persistante chez certaines personnes.

On estime que 836 000 à 2,5 millions d’Américains combattent le syndrome de fatigue chronique, selon les Centers for Disease Control and Prevention des États-Unis. (CDC).

Pour l’étude, l’équipe a tracé une voie possible vers la maladie avec un  traitement des infections chroniques à l’hépatite C,  appelé  interféron alfa,   car le traitement est connu pour induire une fatigue persistante chez certaines personnes.

Les chercheurs ont mesuré la fatigue et l’activité immunitaire de 55 patients ayant reçu un traitement contre l’hépatite C par interféron alfa. Les patients ont été suivis avant, pendant et après le traitement:

  • 18 patients ont développé une fatigue qui a duré plus de six mois après le traitement.
  • Le groupe avec une fatigue de longue durée a également connu une réponse immunitaire accrue.
  • Les marqueurs immunitaires ont été mesurés avec un test sanguin pendant l’étude.
  • Des niveaux plus élevés de ces molécules ont été observés chez ces patients avant le début du traitement.

“Ce que ces données suggèrent fortement, c’est que les personnes qui développent   un syndrome de fatigue chronique  en réponse à une infection le font parce que leur  système immunitaire est prêt à réagir de manière hyperactive  ” , a expliqué Pariante.

Les spécialistes concluent qu’il n’est pas clair pourquoi le système immunitaire d’une personne pourrait être prêt à réagir de manière hyperactive, mais il pourrait probablement s’agir de génétique.

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