Ricerca sul DNA, i risultati mostrano la relazione con la fibromialgia e il dolore cronico. NUOVA SPERANZA!!!

Gli scienziati del  King’s College di Londra  hanno scoperto una relazione tra alterazioni differenziate del DNA (chiamate epigenetiche) e dolore cronico generalizzato nei  punti trigger ,  alcuni situati vicino alle articolazioni, uno dei principali sintomi della fibromialgia. L’epigenetica corrisponde allo studio dei cambiamenti causati da modificazioni nella manifestazione genetica, invece che da alterazioni nel codice genetico del DNA.

Sebbene la fibromialgia sia abbastanza comune, le sue cause alla radice non sono completamente comprese e sono disponibili trattamenti limitati. Non ci sono test diagnostici specifici per la condizione [in questo momento c’è un esame del sangue ] e quelli convenzionali, come I raggi X non sono in grado di rilevare la malattia. I ricercatori ritengono che le loro scoperte aiuteranno gli scienziati di tutto il mondo a sviluppare un diverso esame del sangue per la diagnosi di fibromialgia, che si stima possa influenzare uno di ciascuno 25 persone Lo studio che riporta i risultati è stato pubblicato sulla rivista  PLOS ONE  con il titolo “I fattori epigenetici sono coinvolti nel dolore cronico generalizzato?” Lo studio è stato finanziato da Arthritis Research UK. “La fibromialgia è influenzata da fattori genetici , ma ci sono molti passaggi complicati tra il gene e la malattia.

L’identificazione di collegamenti epigenetici misurabili è un grande passo avanti, ha affermato Williams, uno degli autori dello studio, in un comunicato stampa. “Inoltre, i risultati contribuiranno alla  ricerca futura sulla fibromialgia , così come su molte altre sindromi. dolore cronico, come la  sindrome dell’intestino irritabile “.
I ricercatori hanno utilizzato i gemelli per determinare se il modello dei segni nel DNA (chiamato metilazione del DNA, un meccanismo epigenetico), potesse influenzare l’attività dei geni rispetto alla produzione di determinate proteine, nonché identificare eventuali differenze in cui hanno e quelli che non hanno dolore articolare generalizzato cronico.
I ricercatori hanno trovato tre geni con modelli distinti di metilazione del DNA, in individui con e senza dolore generalizzato cronico.Risultati preliminari indicano che i  pazienti con dolore generalizzato cronico potrebbero avere modelli diversi nel loro DNA.

 e che questo potrebbe modificare l’attività di alcuni geni,  provocando la fibromialgia in primo luogo. “Ci sono milioni di persone nel Regno Unito che convivono con la fibromialgia”, ha affermato Simpson, direttore della ricerca e dei programmi di Arthritis Research UK. “Questa ricerca è davvero entusiasmante ed è un importante passo avanti nella nostra comprensione di come le  differenze epigenetiche tra individui, possono influenzare la nostra probabilità di sviluppare fibromialgia e dolore muscoloscheletrico generalizzato cronico. “” Per molto tempo, le persone con fibromialgia hanno avuto difficoltà a ottenere una diagnosi dei loro sintomi dolorosi. migliore comprensione, diagnosi e trattamento del dolore “, ha detto Simpson.

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