O consumo moderado de álcool ajudaria a reduzir a dor e insônia na fibromialgia.

consumo baixo ou moderado de álcool está associado com o aumento do volume do hipocampo (hipocampo doença de Alzheimer é uma das primeiras regiões do cérebro a sofrer danos. Problemas de memória e desorientação aparecem entre os primeiros sintomas.

Danos ao hipocampo também pode vir de situações de falta de oxigénio (hipoxia), inflamação do cérebro (encefalite) ou epilepsia do lobo temporal. As pessoas que sofreram grandes danos no hipocampo podem experimentar incapacidade de adquirir ou reter novas memórias (amnésia), uma diminuição da intensidade da dor clínica e uma melhor qualidade do sono em pacientes com fibromialgia, de acordo com uma nova pesquisa.

O estudo, “baixo consumo de álcool a moderada é associado com o volume do hipocampo na fibromialgia e insónia , ” foi publicado no Comportamental Medicina do Sono.
Pacientes com fibromialgia frequentemente relatam distúrbios de fadiga e sono. Na verdade, um estudo mostrou que 75% dos pacientes com fibromialgia têm sintomas de insónia crónica.

Fibromialgia e insónia crónica, muitas vezes ocorrem em conjunto, e ambas estão associadas com o aumento da sensibilidade à dor, a qual pode estar relacionada com o hipocampo, uma vez que está envolvida na estímulos de dor.
Estudos têm demonstrado que o volume do hipocampo é reduzida em pacientes com fibromialgia, bem como em pacientes com insónia crónica.
No entanto, não há estudos têm mostrado o impacto da estrutura do hipocampo em pacientes com dor musculoesquelética tanto crónica, e a insónia crónica.

O uso de álcool é de grande interesse nesta área, porque ele executa um número de actividades interessantes devido à sua extensa interacções com uma variedade de sistemas de neurotransmissores, tais como a inibição do GABA (ácido gama amino butirico) e NMDA ( N-metil-aspartato d).

pacientes com fibromialgia têm níveis elevados de ácidos aminados excitatórios que actuam sobre os receptores de NMDA, que estão associados com a hiperalgesia (aumento da sensibilidade à dor) e alodinia (dor resposta a um estímulo que normalmente não provoca dor).
Tem sido demonstrado que a inibição de receptores de GABA promove o sono e reduz a ansiedade.

Por conseguinte, os investigadores poderia supor que o álcool pode ajudar a regular a fibromialgia e insónia sintomas através de inibição dos receptores NMDA e GABA.
Os investigadores da Universidade de Florida investigado se o consumo de álcool em doentes com fibromialgia, com e sem a insónia crónica está associada com as diferenças na estrutura da ressonância magnética hipocampo.
Eles também avaliaram o efeito do álcool sobre uma série de medidas relacionadas com a dor e sono.

Quarenta e um doentes com fibromialgia, dos quais 19 tinham insónia, foram instruídos para completar um papel diariamente com vários parâmetros relacionados com este estudo, incluindo o sono, dor e álcool bebida quantidade de 14 dias.
Isto foi seguido por uma ressonância magnética estrutural para determinar o volume do hipocampo.

Curiosamente, a ressonância magnética mostrou que a maioria tinha (frente e verso) o volume do hipocampo bilateral em bebedores moderados em comparação com os pacientes que se abstiveram, que não tinha sido relatada antes.

O estudo sugere que os bebedores moderados experimentaram menos dor clínica, e melhor qualidade do sono.
No entanto, não houve correlação significativa entre o volume do hipocampo e do sono ou medidas relacionadas com a dor.

Portanto, o álcool pode ajudar os sintomas da fibromialgia, agindo em vários níveis, em vez de apenas no hipocampo.
“Indivíduos com fibromialgia sozinho, ou fibromialgia e insónia crónica, com menor consumo de álcool para moderar sintomas relatados menos dor, e tinha uma significativamente maior do que abstainers hipocampo , ” escreveu os autores.

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