Nuwe entstof vir fibromialgie-behandeling wat eintlik werk. Lees asb

As iemand vir u ‘n entstof kan gee wat u fibromialgie sou genees, sou u dit dan doen? Dit klink miskien na ‘n droom, maar dit is nader aan die werklikheid as wat u dink. ‘N Biomediese firma EpicGenetics   en Massachusetts General Hospital, wat in Los Angeles gebaseer   is, soek goedkeuring van die Amerikaanse voedsel- en medisyne-administrasie (FDA) om volgende jaar ‘n kliniese proef te doen om die Bacille Calmette-Guerin (BCG)   -entstof te toets   as ‘n moontlike behandeling vir fibromialgie.

BCG is ‘n generiese entstof teen tuberkulose wat byna 100 jaar oud is en miljoene kere veilig toegedien is, ”het dr. Denise Faustman, hoof van die Faustman Lab by die Massachusetts General Hospital. “Ons navorsingsgroep in die Massachusetts General Hospital ondersoek meer as tien jaar aktief die rol wat die BCG-entstof kan speel in die behandeling van verskillende vorme van outo-immuniteit. Ons huidige fokus is op tipe 1-diabetes, maar wêreldwyd word BCG getoets in ‘n verskeidenheid outo-immuun siektes. Oor die volgende twee jaar begin ons met kliniese toetsing van BCG in fibromialgie. “

Volgens die Wêreldgesondheidsorganisasie ontvang meer as 100 miljoen kinders die BCG-entstof elke jaar. Dit word hoofsaaklik in ontwikkelende lande gebruik waar tuberkulose nog steeds aktief is. Die BCG-entstof is nie in die Verenigde State beskikbaar nie weens die lae infeksierisiko. In die Verenigde State word BCG vir ‘n klein aantal pasiënte gebruik om blaaskanker te behandel.

Die voor die hand liggende vraag is waarom moet ‘n entstof teen ‘n aansteeklike longtoestand gebruik word vir fibromialgie? Die antwoord lê binne die immuunstelsel.

Entstowwe word gewoonlik aan gesonde mense gegee om infeksie te voorkom. In hierdie geval sal die BCG-entstof egter aan fibromialgie-pasiënte toegedien word om hul simptome te verswak.

Toe EpicGenetics etlike jare gelede ‘n diagnostiese toets vir fibromialgie gemaak het, het navorsers allerlei laboratoriumtoetse op fibromialgie-pasiënte gedoen om uit te vind hoe hulle verskil van gesonde kontroles en wat moontlik hul simptome kan veroorsaak. Navorsers het verskeie witbloedselle-abnormaliteite by fibromialgie-pasiënte ontdek, wat gelei het tot die gevolgtrekking dat simptome geassosieer word met ‘n onderdrukte immuunstelsel.

“Ons dink [die term] fibromialgie is ‘n foutnommer,” het dr. Bruce Gillis, uitvoerende hoof van EpicGenetics. “Hierdie mense ly nie met iets wat die spiere beïnvloed nie, per. Sê. Waaraan hulle ly, is dat hul immuunstelsel nie normale hoeveelhede beskermende proteïene kan produseer nie. … Daar is selle in die immuunstelsel wat perifere mononukleêre bloedselle genoem word. Hulle produseer nie normale hoeveelhede van die beskermende proteïene wat chemokiene en sitokiene genoem word nie. “

Die bevinding het gelei tot die ontwikkeling van FM / bloedtoets vir fibromialgie. (Ja, ten spyte van wat u dokters u gesê het, is daar ‘n bloedtoets vir fibromialgie! Dit word net nie algemeen aanvaar in die mediese gemeenskap nie.) Die toets ontleed die vlakke van vier chemokiene en sitokiene wat in verminderde vlakke van fibromialgie voorkom. pasiënte. Hierdie vier chemokiene en sitokiene is presies dieselfde as wat die BCG-entstof verhoog.

“In die lig van wat in die mediese literatuur gepubliseer is, glo ons dat hierdie entstof die abnormaliteite van die immuunstelsel (van fibromialgie) sal keer,” het Gillis gesê.

Gillis en Faustman vra FDA-goedkeuring om die eerste BCG-entstowwe vroeg volgende jaar toe te dien vir fibromialgie-pasiënte.

“Dit is die eerste keer dat ‘n direkte behandeling van fibromialgie plaasvind,” het Gillis gesê. ‘Soos u weet, behandel medisyne [tans in die mark] vir fibromialgie slegs simptome. Dit hou geen voordele vir die immuunstelsel in nie. [Die farmaseutiese ondernemings] erken dat hulle slegs simptome behandel, maar dat u die siekte moet behandel, en daarom gaan ons voort met die toediening van die entstof [na die FDA]. “

As Gillis se teorie korrek is, sal die chemokiene en sitokiene wat nie pasiënte met fibromialgie bevat nie, nie meer gebrekkig wees nie (wanneer die BCG-entstof toegedien word), het Gillis gesê. “Die produksiepeil is genormaliseer en daar moet aanvaar word dat hul simptome verdwyn. Ons dink ons ​​is aan die voorpunt van iets groots. “

Aangesien die entstof so ‘n lang geskiedenis het, word daar nie verwag dat dit enige ernstige newe-effekte by pasiënte sal veroorsaak nie.

Die BCG-entstof sal na verwagting $ 20- $ 25 per dag kos. Dosis – ‘n nominale bedrag in vergelyking met die huidige koste om medisyne elke dag te neem.

“Ons dink dat ‘n fibromialgie-pasiënt ‘n maksimum van een of twee dosisse benodig, sodat u kan verstaan ​​hoekom ek nie veel steun van farmaseutiese ondernemings kry nie,” het Gillis gesê.

Benewens die entstofproef is EpicGenetics ook ‘n samewerking met die Universiteit van Kalifornië, Los Angeles (UCLA) en die University of Illinois College of Medicine Chicago om die genome van tot 250,000 fibromialgie-pasiënte op te volg.

“Ons is op soek na enige soort genetiese patroon of afwyking of mutasie,” het Gillis gesê.

Pasiënte wat positief toets vir fibromialgie met behulp van FM / ‘n toets, sal aan die genomiese studie kan deelneem.

FM / een-toetsing kos tans $ 936, maar word deur sommige versekeringsmaatskappye en Medicare gedek. EpicGenetics se ondersteuningspan help pasiënte om te besluit of hul versekeringsmaatskappy die toets sal dek. ‘N Rentevrye betaalplan is beskikbaar vir mense wat nie verseker is nie, of wie se versekering nie die toets dek nie.

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