Fibromialgie is ‘n chroniese toestand wat gekenmerk word deur ‘n kombinasie van wydverspreide pyn in die spiere, senings, ligamente, moegheid en verskeie tere punte in die liggaam. Sagte punte is spesifieke areas wat pynlik of teer is wanneer druk toegepas word, veral op die nek, skouers, rug, bo-bors, elmboë, onderrug, heupe en die dye.
Mense met fibromialgie kan ook ander simptome en toestande ervaar , soos swak slaap, prikkelbare dermsindroom, hoofpyn, TMJ-versteurings, angs, depressie, rustelose bene-sindroom, gevoelloosheid of tinteling in die hande en voete, Swakkonsentrasie, pynlike menstruasieperiodes en verhoogde sensitiwiteit vir reuke, geraas, helder ligte en aanraking. Dit raak tussen 3 en 6 miljoen mense in die Verenigde State. Fibromialgie is die algemeenste by vroue, veral tussen die ouderdom van 30 en 50 jaar. Daar is tans geen wetenskaplike ondersteuning vir die eis van enige spesifieke middel wat fibromialgie kan behandel nie.
S-Adenosylmetionine (SAMe) S-Adenosylmetionine (SAMe) is ‘n verbinding wat natuurlik in die liggaam voorkom. Dit is nodig vir die korrekte werking van die immuunstelsel, selmembrane, neurotransmitters soos serotonien, norepinefrien en dopamien, kraakbeen en DNA. ‘N Paar voorstudies dui daarop dat SAMe kan help met fibromialgie.
‘N Klein dubbelblinde studie het die effek van S-adenosielmetionien geëvalueer. Die aantal tenderpunte het na SAMe afgeneem, maar nie na placebo nie.
Depressie, soos beoordeel deur twee graderingskale, het na SAMe verbeter maar nie placebo nie. ‘n Ander studie het getoon dat daar na 6 weke statisties beduidende verbeterings was in pyn, moegheid, oggendstyfheid, bui en kliniese siekteaktiwiteit. Tere puntetelling, spierkrag en gemoedstoestand (soos beoordeel deur die Beck Depression Inventory) was nie beduidend beter by SAMe as by placebo nie. Moontlike newe-effekte: SAMe kan slegte spysvertering, droë mond en slapeloosheid veroorsaak. In seldsame gevalle ervaar mense ernstige diarree, sooibrand, hoofpyn en duiseligheid. Mense met bipolêre versteuring moet nie SAMe gebruik nie , want dit kan maniese episodes vererger.
Mense wat die geneesmiddel levodopa gebruik (wat gewoonlik voorgeskryf word vir die siekte van Parkinson), moet SAMe vermy.
Mense wat antidepressante gebruik, moet nie SAMe gebruik sonder om eers hul dokter te raadpleeg nie.
Die veiligheid van SAMe by swanger of verpleegkundiges of kinders is nie vasgestel nie.
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