Nouveau vaccin pour le traitement de la fibromyalgie qui fonctionne réellement

Si quelqu’un pouvait vous administrer un vaccin qui pourrait guérir votre fibromyalgie, le feriez-vous? Cela peut sembler un rêve, mais il est plus proche de la réalité que vous ne le pensez. Les laboratoires biomédical Epic Genetics , basés à Los Angeles,       et le Massachusetts General Hospital cherchent à obtenir l’ autorisation de la FDA  pour tester le vaccin  Bacillus Calmette-Guérin (BCG)l’année prochaine en tant que traitement potentiel de la fibromyalgie.

Le BCG est un vaccin générique contre la tuberculose qui a presque 100 ans et qui a été administré sans risque des millions de fois », a déclaré le Dr Denise Faustman, directrice du laboratoire Faustman au Massachusetts General Hospital. “Depuis plus de dix ans, notre groupe de recherche du Massachusetts General Hospital explore activement le rôle du vaccin BCG dans le traitement de diverses formes d’auto-immunité. Notre objectif actuel est le diabète de type 1, mais globalement, le BCG est testé dans un certain nombre de maladies auto-immunes. Au cours des deux prochaines années, nous commencerons des essais cliniques sur le BCG dans la fibromyalgie. “

Selon l’Organisation mondiale de la santé, plus de 100 millions d’enfants reçoivent le vaccin BCG chaque année. Il est principalement utilisé dans les pays en développement où la tuberculose est toujours active. Le vaccin BCG n’est pas disponible aux États-Unis en raison du faible risque d’infection. Aux États-Unis, le BCG est utilisé chez un petit nombre de patients pour traiter le cancer de la vessie.

La question évidente est: pourquoi utiliser un vaccin contre les maladies pulmonaires infectieuses contre la fibromyalgie? La réponse est dans le système immunitaire.

Les vaccins sont généralement administrés à des personnes en bonne santé pour prévenir l’infection. Dans ce cas, cependant, le vaccin BCG serait administré aux patients atteints de fibromyalgie pour soulager leurs symptômes.

Lorsque EpicGenetics a été chargé de produire un test de diagnostic de la fibromyalgie il y a quelques années, les chercheurs ont effectué tous les types de tests de laboratoire sur des patients atteints de fibromyalgie afin de déterminer leur différence par rapport aux contrôles sains et leurs symptômes. Les chercheurs ont découvert plusieurs anomalies des globules blancs chez des patients atteints de fibromyalgie, ce qui a permis de conclure que les symptômes sont liés à un système immunitaire affaibli.

“Nous pensons que [le terme] fibromyalgie est un terme inapproprié”, a déclaré le Dr Bruce Gillis, PDG d’Epic Genetics. “Ces personnes, par exemple, ne souffrent pas de quelque chose qui affecte les muscles. Parmi eux, ils souffrent que leur système immunitaire ne peut pas produire des niveaux normaux de protéines protectrices. … Il existe dans le système immunitaire des cellules appelées cellules du sang périphérique mononucléées. Ils ne produisent pas des niveaux normaux de protéines protectrices appelées chimiokines et cytokines. “

Cette découverte a conduit à la mise au point d’un test FM / analyse sanguine de la fibromyalgie. (Oui, malgré les déclarations de vos médecins, il existe un test sanguin pour la fibromyalgie qui n’est pas accepté en médecine.) Le test analyse les niveaux de quatre chimiokines et cytokines trouvés en quantités réduites chez les patients atteints de fibromyalgie – ces quatre chimiokines et cytokines sont les mêmes que ceux stimulés par le vaccin BCG.

“Compte tenu de ce qui a été publié dans la littérature médicale, nous pensons que ce vaccin inversera les anomalies du système immunitaire [fibromyalgie]”, a déclaré Gillis.

Gillis et Faustman cherchent à obtenir l’approbation de la FDA pour administrer les premiers vaccins BCG chez les patients atteints de fibromyalgie au début de l’année prochaine.

“C’est la première fois qu’un traitement direct contre la fibromyalgie est réalisé”, a déclaré Gillis. “Comme vous le savez, les médicaments anti-fibromyalgie actuellement sur le marché traitent uniquement les symptômes. Ils n’ont aucun avantage sur le système immunitaire. [Les sociétés pharmaceutiques] admettent qu’elles doivent seulement traiter les symptômes, mais elles doivent également traiter la maladie. Nous progressons donc dans l’utilisation du vaccin [à la FDA]. “

Si la théorie de Gillis est vraie, alors “les chimiokines et les cytokines déficientes chez les patients atteints de fibromyalgie ne le seront plus [une fois que le vaccin BCG aura été administré”, a déclaré Gillis. “Les niveaux de production se normalisent et vous devez supposer que leurs symptômes disparaissent. Nous pensons que nous sommes au bord de quelque chose de grand. “

Comme le vaccin a une longue histoire, il ne devrait pas causer d’effets secondaires majeurs chez les patients.

Le vaccin BCG devrait coûter entre 20 et 25 dollars par dose – un montant nominal comparé au coût actuel des médicaments quotidiens.

“Nous pensons qu’un patient atteint de fibromyalgie a besoin d’une ou deux doses pour comprendre pourquoi les sociétés pharmaceutiques ne me soutiennent pas beaucoup”, a déclaré Gillis.

Outre l’essai du vaccin, EpicGenetics collabore avec l’Université de Californie à Los Angeles (UCLA) et le Chicago College of Medicine de l’Université de l’Illinois pour séquencer les génomes de 250 000 patients atteints de fibromyalgie.

“Nous recherchons des modèles génétiques, des anomalies ou des mutations”, a déclaré Gillis.

Les patients atteints de fibromyalgie positive qui utilisent le test FM / un test peuvent participer à l’étude du génome.

Le test FM / A coûte actuellement 936 dollars, mais il est couvert par certaines compagnies d’assurance et Medicare. L’équipe de soutien EpicGenetics aide les patients à déterminer si leur assurance couvre le test. Pour ceux qui ne sont pas assurés ou dont l’assurance ne couvre pas le test, un plan de paiement sans intérêt est disponible.

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