Nieuw vaccin voor behandeling met fibromyalgie dat echt werkt. Moet lezen

Als iemand je een vaccin zou kunnen geven dat je fibromyalgie zou genezen, zou je het dan doen? Dat klinkt misschien als een droom, maar het is dichter bij de werkelijkheid dan je zou denken. Het in Los Angeles gevestigde biomedische bedrijf  EpicGenetics  en de onderzoekers van het Massachusetts General Hospital zoeken goedkeuring van de Amerikaanse Food and Drug Administration (FDA) om volgend jaar een klinisch onderzoek uit te voeren om het Bacille Calmette-Guerin (BCG)  -vaccin te testen  als een potentiële behandeling voor fibromyalgie.

BCG is een generiek tuberculosevaccin dat bijna 100 jaar oud is en miljoenen keren veilig is toegediend, “verklaarde Dr. Denise Faustman, hoofd van het Faustman Lab in het Massachusetts General Hospital. “Al meer dan 10 jaar onderzoekt onze onderzoeksgroep in het Massachusetts General Hospital actief de rol die het BCG-vaccin zou kunnen spelen bij de behandeling van verschillende vormen van auto-immuniteit. Onze huidige focus is type 1 diabetes, maar wereldwijd wordt BCG getest in een aantal auto-immuunziekten. In de komende twee jaar zullen we beginnen met het klinisch testen van BCG bij fibromyalgie. ”

Volgens de Wereldgezondheidsorganisatie krijgen jaarlijks meer dan 100 miljoen kinderen het BCG-vaccin. Het wordt voornamelijk gebruikt in ontwikkelingslanden waar tuberculose nog steeds actief is. Het BCG-vaccin is niet verkrijgbaar in de Verenigde Staten vanwege het lage infectierisico. In de VS wordt BCG bij een klein aantal patiënten gebruikt om blaaskanker te behandelen.

Dus de voor de hand liggende vraag is waarom zou een vaccin voor een infectieuze longaandoening worden gebruikt voor fibromyalgie? Het antwoord ligt in het immuunsysteem.

Vaccins worden meestal aan gezonde mensen gegeven om infectie te voorkomen. In dit geval zou het BCG-vaccin echter worden toegediend aan fibromyalgiepatiënten in een poging hun symptomen te onderdrukken.

Toen EpicGenetics enkele jaren geleden een diagnostische test voor fibromyalgie moest uitvoeren, voerden onderzoekers allerlei laboratoriumtests uit bij fibromyalgiepatiënten om erachter te komen hoe ze verschilden van gezonde controlepersonen en wat hun symptomen zouden kunnen veroorzaken. Onderzoekers ontdekten verschillende abnormaliteiten van witte bloedcellen bij fibromyalgiepatiënten, waardoor ze concluderen dat symptomen geassocieerd zijn met een onderdrukt immuunsysteem.

Beeldresultaat voor Nieuw vaccin voor behandeling met fibromyalgie dat echt werkt. Moet lezen

“Wij geloven dat fibromyalgie een verkeerde benaming is”, zegt dr. Bruce Gillis, CEO van EpicGenetics. “Deze mensen lijden niet per ongeluk aan iets dat de spieren beïnvloedt. Waar ze mee worstelen, is dat hun immuunsysteem geen normale hoeveelheden beschermende eiwitten kan produceren. … Er zijn cellen in het immuunsysteem, mononucleaire cellen uit perifeer bloed. Ze produceren geen normale hoeveelheden van de beschermende eiwitten die chemokines en cytokines worden genoemd. ”

De bevinding leidde tot de ontwikkeling van de FM / a-bloedtest voor fibromyalgie. (Ja, ondanks wat uw artsen u hebben verteld, IS er een bloedtest voor fibromyalgie! Het wordt gewoon niet algemeen aanvaard in de medische gemeenschap.) De test analyseert de niveaus van vier chemokinen en cytokinen die bij lagere niveaus bij fibromyalgiepatiënten worden aangetroffen. Deze vier chemokines en cytokines zijn toevallig dezelfde die worden versterkt door het BCG-vaccin.

“Gezien wat in de medische literatuur is gepubliceerd, geloven we dat dit vaccin de abnormaliteiten van het immuunsysteem [van fibromyalgie] zal omkeren”, zei Gillis.

Gillis en Faustman zijn op zoek naar toestemming van de FDA om de eerste BCG-vaccins tegen fibromyalgiepatiënten begin volgend jaar toe te dienen.

“Dit is de eerste keer ooit dat een directe behandeling van fibromyalgie zal worden gedaan,” zei Gillis. “Zoals je weet, behandelen de medicijnen [die momenteel op de markt zijn] voor fibromyalgie alleen symptomen. Ze hebben geen voordelen voor het immuunsysteem. [De farmaceutische bedrijven] geven toe dat ze alleen symptomen behandelen, maar je moet de ziekte behandelen, en daarom gaan we verder met de vaccinaanvraag [aan de FDA]. ”

Beeldresultaat voor Nieuw vaccin voor behandeling met fibromyalgie dat echt werkt. Moet lezen

Als de theorie van Gillis klopt, dan zullen “de chemokinen en cytokines die deficiënt zijn in patiënten met fibromyalgie niet langer tekortschieten [zodra het BCG-vaccin is toegediend]”, zei Gillis. “Productieniveaus zullen normaliseren, en je moet dan aannemen dat hun symptomen zullen verdwijnen. We denken dat we aan de vooravond staan ​​van iets belangrijks. ”

Omdat het vaccin zo’n lange geschiedenis heeft, wordt niet verwacht dat het bij patiënten grote bijwerkingen veroorzaakt.

Het BCG-vaccin zal naar verwachting $ 20- $ 25 per dosis kosten – een nominaal bedrag in vergelijking met de lopende kosten van het dagelijks innemen van geneesmiddelen.

“We denken dat een fibromyalgiepatiënt een of twee doses maximaal nodig heeft, zodat je begrijpt waarom ik niet veel steun krijg van farmaceutische bedrijven,” zei Gillis.

Naast de vaccinproef werkt EpicGenetics samen met de University of California, Los Angeles (UCLA) en het University of Illinois College of Medicine Chicago om het genoom van maximaal 250.000 fibromyalgiepatiënten te sequencen.

“We zijn op zoek naar elk type genetische patronen of anomalieën of mutaties”, zei Gillis.

Patiënten die positief testen op fibromyalgie met behulp van de FM / a-test, zullen kunnen deelnemen aan de genomische studie.

De FM / a-test kost momenteel $ 936, maar wordt gedekt door een aantal verzekeringsmaatschappijen en Medicare. Het ondersteuningsteam van EpicGenetics helpt patiënten te bepalen of hun verzekeringsmaatschappij de test zal afleggen. Een niet-rente betalingsplan is beschikbaar voor mensen die niet verzekerd zijn of wiens verzekering de test niet dekt.

Ga naar FMTest.com als u meer wilt weten over de FM / a-test. Klik hier om meer te lezen over het fibromyalgie-genoomproject van EpicGenetics en de BCG-vaccinstudie. Als u geïnteresseerd bent in het hebben van de FM / a-test, vul dan het aanvraagformulier in op de startpagina op FMTest.com. Als u nog vragen heeft of problemen ondervindt bij het indienen van het formulier, kunt u een e-mail sturen naar ask@epicgtx.com of bellen naar (310) 277-4600.

Over de auteur:

Donna Gregory Burch werd in 2014 gediagnosticeerd met fibromyalgie na enkele jaren van onverklaarbare pijn, vermoeidheid en andere symptomen. Later kreeg ze de diagnose chronische Lyme-borreliose. Donna behandelt nieuws, behandelingen, onderzoek en praktische tips om beter te leven met fibromyalgie en Lyme op haar blog,  FedUpwithFatigue.com . Je kunt haar ook vinden op Facebook  en  Twitter . Donna is een bekroonde journalist wiens werk online is verschenen en in kranten en tijdschriften in Virginia, Delaware en Pennsylvania. Ze woont in Delaware met haar man en hun vele vachtbaby’s.

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