Neurontin et sa nouvelle version plus puissante, Lyrica, sont largement utilisés pour les indications hors indication qui constituent un danger flagrant pour le public. Ces médicaments à succès ont été approuvés pour utilisation même si la FDA n’avait aucune idée de ce qu’ils ont réellement fait dans le cerveau. Une nouvelle étude choquante montre qu’ils bloquent la formation de nouvelles synapses cérébrales 1 , réduisant considérablement le potentiel de rajeunissement de la plasticité cérébrale – ce qui signifie que ces médicaments provoqueront un déclin cérébral plus rapide que n’importe quelle substance connue de l’humanité.
Le problème de ces drogues est aggravé par leur marketing illégal flagrant. Neurontin a été approuvé par la FDA pour l’épilepsie en 1994. Le médicament a fait l’objet d’une promotion massive et illégale hors-étiquette qui a coûté 430 millions de dollars à Warner-Lambert (la première grande amende pour la promotion hors label). Le médicament est maintenant détenu par Pfizer. Pfizer possède également Lyrica, une version super-puissante de Neurontin. Il a été approuvé par la FDA pour différents types de douleur et de fibromyalgie. Lyrica est l’un des quatre médicaments commercialisés illégalement par une filiale de Pfizer, ce qui représente un règlement de 2,3 milliards de dollars contre Pfizer.
Même si le marketing de ces médicaments a été lourdement sanctionné, ils continuent d’accumuler des milliards de dollars de ventes à partir des utilisations hors AMM. Les médecins les utilisent pour toutes sortes de problèmes nerveux, car ils sont efficaces pour supprimer les symptômes. Cependant, de telles utilisations ne peuvent plus être justifiées car le mécanisme réel des médicaments est finalement compris et ils créent une réduction significative à long terme de la santé nerveuse.
Les chercheurs de l’étude ci-dessus essaient de minimiser la nature sérieuse des médicaments en disant que «les neurones adultes ne forment pas beaucoup de nouvelles synapses». Ce n’est tout simplement pas vrai. La nouvelle science montre que la santé du cerveau au cours du vieillissement repose sur la formation de nouvelles synapses. Même ces chercheurs ont réussi à remettre en question l’utilisation commune de ces médicaments chez les femmes enceintes. Comment un fœtus est-il supposé fabriquer de nouvelles cellules nerveuses lorsque la mère prend un médicament qui le bloque?
Ce sont le genre de situations que la FDA devrait être partout. Comme d’habitude, la FDA réfléchit à un avertissement de suicide pour Lyrica alors que ses utilisations hors AMM comprennent les troubles bipolaires et les migraines. La FDA est susceptible de se tourner les pouces pour la prochaine décennie sur la question des dommages au cerveau. Consommateur méfiez-vous.
Études référencées
Neurontin et Lyrica sont hautement toxiques pour les nouvelles synapses cérébrales Cell Çagla Eroglu, Nicola J. Allen, Michael W. Susman, Nancy A. O’Rourke, Parc Chan Young, Engin Özkan, Chandrani Chakraborty, Sara B. Mulinyawe, Douglas S. Annis , Andrew D. Huberman, Eric M. Green, Jack Lawler, Ricardo Dolmetsch, K. Christopher Garcia, Stephen
Bonjour en gros car serait trop long donner tous les explications mais…
Mon docteur m’avais prescrit ce médicament la.
Au moins pendant 6 mois de temps
Suite a une dystrophie dans une jambe cassé 2010
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