O Neurontin e sua nova versão mais potente, Lyrica, são amplamente usados para indicações off-label que são um perigo flagrante para o público. Essas drogas campeãs de vendas foram aprovadas para uso, embora a FDA não tivesse ideia do que elas realmente faziam no cérebro. Um novo estudo chocante mostra que eles bloqueiam a formação de novas sinapses cerebrais 1 , reduzindo drasticamente o potencial de rejuvenescimento da plasticidade cerebral – o que significa que essas drogas causam o declínio cerebral mais rapidamente do que qualquer substância conhecida pela humanidade.
O problema dessas drogas é agravado pelo flagrante marketing ilegal. O Neurontin foi aprovado pelo FDA para a epilepsia em 1994. O medicamento foi submetido a uma massiva promoção ilegal que custou 430 milhões de dólares à Warner-Lambert (a primeira grande multa por promoção off-label). A droga é agora propriedade da Pfizer. A Pfizer também é dona do Lyrica, uma versão super potente do Neurontin. Foi aprovado pelo FDA para vários tipos de dor e fibromialgia. Lyrica é uma das quatro drogas que uma subsidiária da Pfizer comercializou ilegalmente, resultando em um acordo de US $ 2,3 bilhões contra a Pfizer.
Mesmo que o marketing desses medicamentos tenha sido altamente multado, eles continuam acumulando bilhões em vendas com os usos off-label. Os médicos os usam para todos os tipos de problemas nervosos porque são bons em suprimir os sintomas. No entanto, tais usos não podem mais ser justificados porque o mecanismo atual das drogas é finalmente entendido e eles estão criando uma redução significativa a longo prazo na saúde nervosa.
Os pesquisadores do estudo acima tentam minimizar a natureza séria das drogas, dizendo que “os neurônios adultos não formam muitas novas sinapses”. Isso simplesmente não é verdade. A nova ciência está mostrando que a saúde do cérebro durante o envelhecimento depende da formação de novas sinapses. Mesmo esses pesquisadores conseguiram questionar o uso comum desses medicamentos em gestantes. Como um feto deve fazer novas células nervosas quando a mãe está tomando uma droga que as bloqueia?
Estes são os tipos de situações que a FDA deve estar por toda parte. Como de costume, o FDA está sentado pensando em um alerta suicida para Lyrica, enquanto seus usos off-label incluem transtorno bipolar e enxaqueca. A FDA deve mexer seus polegares pela próxima década na questão dos danos cerebrais. Cuidado com o consumidor.
Estudos Referenciados
Neurontin e Lyrica são altamente tóxicos para as novas sinapses cerebrais Célla Eroglu, Nicola J. Allen, Michael W. Susman, Nancy A. O’Rourke, Chan Young Park, Engin Özkan, Chandrani Chakraborty, Sara B. Mulinyawe, Douglas S. Annis , Andrew D. Huberman, Eric M. Verde, Jack Lawler, Ricardo Dolmetsch, K. Christopher Garcia, Stephen
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