The dysautonomia in FM patients can be characterized by unrelenting sympathetic hyperactivity throughout the day associated with a deranged sympathetic response to different stressors. The authors
The autonomic nervous system (ANS) appears to be the subject of the week for Health Rising. This study combines the autonomic nervous system with lung functioning – an issue that has not been talked in fibromyalgia that I am aware of.
People don’t typically tie fibromyalgia or chronic fatigue syndrome in with lung issues but they do crop up – particularly in ME/CFS – at times. Some people experience “air hunger” or difficulty breathing or difficulty taking deep breaths. Some studies suggest that ventilation – the movement of air in and out of the lung – may be reduced during exercise in some ME/CFS patient. Staci Stevens, an exercise physiologist, has wondered whether the small and highly active muscles involved in breathing could be impacted in this disease.
Lung issues may not be the major symptom associated with FM but problems with the lungs could be telling if they were a manifestation of another problem associated with the autonomic nervous system.
The authors got to the heart of matter in this paper quickly. They reported that the sympathetic nervous system (SNS) in fibromyalgia ) is hyperactive at rest but then folds or crashes when put under stress; i.e. you’re wired and tired at “rest” (some rest!) and then things tend to go haywire when you system is put under stress. (The same pattern is present in chronic fatigue syndrome (ME/CFS))
How did they connect the lungs to fibromyalgia? They used diabetes. Diabetes is not mentioned much in connection with fibromyalgia, but the authors pointed to a similar ANS problem in diabetes which leads to problems with blood vessel filling in the very small (microvascular) blood vessels in the lungs. In diabetes this leads to a problem with carbon monoxide diffusion from the lungs.
That’s the same thing that appears to be happening in FM.
The Study
They took 45 FM patients and 45 controls and did a bunch of autonomic nervous system and lung volume and gas transfer tests including something called transfer factor which measures the capacity of the lung to diffuse carbon monoxide out of it. They also had them take a 31 question autonomic questionnaire called the Composite Autonomic Symptom Score or COMPASS.
Results
FM patients have functional microcirculation and morphological abnormalities and the abnormal pattern of reactive hyperemia is due to greater sympathetic tone leading to increased vasoconstriction. The authors
They noted that fibromyalgia patients scores on the autonomic questionnaire (COMPASS) were highly correlated with those on the Fibromyalgia Impact Questionnaire (FIQ). That suggested that the autonomic nervous system problem could be contributing to many symptoms in FM.
The FM patients lungs didn’t look so good. Total lung volume was fine, but every measure of lung functioning (carbon monoxide transfer factor, carbon monoxide diffusion capacity, alveolar capillary membrane volume and pulmonary capillary blood volume) were significantly reduced in the fibromyalgia patients.
Further analyses found that the reduction in lung diffusing capacity was probably due to a significant reduction in lung capillary lung volume; i.e. the microvascular volume of the FM patients lungs had declined.
Both the smallest and most common blood vessels found, our capillaries are responsible for delivering blood to most of our tissues. They are so small that a red blood cell can just barely fit through them. As they are delivering red blood cells they are also allowing small molecules such as oxygen, CO2, sugars and amino acids to diffuse in and out of them. That diffusion part is apparently not working very well.
The authors suggested that damage to the cardiac autonomic nerves was causing problems with “the regulation of microvascular tone” and the distribution of pulmonary filling. They proposed that the receptors on our cells that cause FM patients blood vessels to dilate have been so overstimulated over time that they’re not responding to signals to dilate anymore. That leaves the blood vessels constricted, impairs blood flows and even (I believe) could reduce blood volume.
The authors ticked off a number of findings suggesting that circulation problems would be no surprise in FM. Reduced nitric oxide production prevents the blood vessels from opening sufficiently to move the blood vessels in FM patients from opening sufficiently to move the blood properly and causing arterial wall stiffness.
They also noted the high rates of Raynaud’s phenomena found in the FM participants in this study (1/3rd). Raynaud occurs when spasms in the arteries restrict blood flows usually to hands or feet causing the fingers or toes usually to turn white, then blue and then as the blood returns, causes them to tingle or burn. This is often caused by exposure to reduced temperatures. In some people being exposed to temperatures below 60 degrees can cause Reynaud’s.
The fact that the FM patients with Raynaud’s phenomena tended to have worse lung test results made sense given the similar sympathetic nervous system hyperactivity found in Raynaud’s. That, local hyperactivity, which affects the arteries not the smaller blood vessels found in the lungs, is so extreme that it causes the blood vessels become vasoconstricted or narrowed enough that the blood cannot get through.
Raynaud’s then appears to be another manifestation of a dysregulated autonomic nervous system in FM.
The authors didn’t spend any time on the clinical significance of their findings and it’s not clear from the paper what they are. Reduced carbon dioxide diffusion is found in many lung diseases (fibrosis, alveolitis, vasculitis, COPD, emphysema, pulmonary hypertension) as well as anemia (low blood volume). It’s not clear if they would contribute to shortness of breath or breathing problems sometimes found in ME/CFS or FM or if they reflect a problem which is present but which isn’t causing many symptoms.
This isn’t the first time that possible microcirculatory problems have popped up in FM, however. The authors of a 2014 exercise study proposed that microcirculatory problems could be contributing to the low VO2 max findings they found in FM patients. They argued that the next exercise study in FM should examine blood flows in the small blood vessels feeding the muscles.
- See Lending a Hand: A Very Different Approach to Fibromyalgia for information on a machine that purports to increase the microcirculation in FM
Nerve Damage Proposed
These authors proposed that damage to the autonomic cardiac nerves was mostly likely to explain the blunted lung functioning. This, of course, is not the first time that damage to the autonomic nerves has been proposed or found in FM. Autonomic nerves are among the small nerve fibers that many studies have now found damaged in the skin of FM patients.
Last year that damage was extended to nerve fibers in the eye. Recently Sommers found such an unusual pattern of nerve damage in FM that she now calls it “small fiber pathology” to distinguish it from the more typical small fiber neuropathy found in other disorders. Caro and Winters have found damage to large nerve fibers in FM as well.
About a year ago a researcher suggested that the deep researchers look at nerves the more they are likely to find. Her prediction appears to be coming true. From the skin to the eyes to possibly the lungs nerve problems are cropping up in fibromyalgia.
What could be causing these nerve problems? If a Spanish group’s skin findings hold up then a brew of inflammation, mitochondrial problems and oxidative stress might fill the bill.
Courtesy : https://www.healthrising.org
Traders do pay direct and oblique prices.
Simply wish to say your article is as amazing. The clearness in your post is
just nice and i could assume you are an expert on this subject.
Fine with your permission let me to grab your RSS feed to keep updated with forthcoming post.
Thanks a million and please continue the rewarding work.
I visited various sites except the audio feature for audio
songs present at this website is really wonderful.
My partner and I absolutely love your blog and find a lot of
your post’s to be exactly what I’m looking for. Does one offer guest writers to write content
to suit your needs? I wouldn’t mind writing a post or elaborating on a number
of the subjects you write concerning here. Again, awesome website!
bookmarked!!, I love your blog!
I was recommended this website through my cousin. I’m now
not sure whether or not this put up is written via him as no
one else know such detailed approximately my trouble.
You’re amazing! Thank you!
Do you mind if I quote a few of your posts as long as I provide credit and sources back to your webpage?
My website is in the very same area of interest as yours and
my users would really benefit from some of the information you provide here.
Please let me know if this okay with you. Many thanks!
Hi! I’ve been reading your web site for some time now and finally
got the bravery to go ahead and give you a shout out from Humble
Texas! Just wanted to tell you keep up the excellent job!
Hello! I’ve been reading your blog for some time now and finally got the courage to go ahead and
give you a shout out from Humble Tx! Just wanted
to mention keep up the good job!
I’m really enjoying the theme/design of your website. Do you ever run into any
browser compatibility issues? A couple of my blog audience have complained about my site not working correctly in Explorer but looks great in Opera.
Do you have any tips to help fix this issue?
I was suggested this website by my cousin. I’m not sure whether this post is written by him as nobody else know such detailed about my difficulty.
You are amazing! Thanks!
Think about investments that supply speedy annuities.
Hello, yup this article is in fact nice
and I have learned lot of things from it on the topic of blogging.
thanks.
I do trust all of the ideas you’ve introduced on your post.
They’re really convincing and can definitely work.
Still, the posts are very short for starters. Could you please lengthen them
a little from next time? Thanks for the post.
Consider investments that offer speedy annuities.
We’re a group of volunteers and starting a
new scheme in our community. Your web site
offered us with valuable info to work on. You’ve done a formidable job
and our entire community will be thankful to you.
Thanks very interesting blog!
Thanks for finally talking about >Nerve Damage Affecting the Lungs in Fibromyalgia
: New Study – HEALTHY LIVING AT HOME <Loved it!
Undeniably consider that that you said. Your favorite
reason seemed to be on the internet the simplest factor to consider of.
I say to you, I definitely get irked even as other people consider worries that they just don’t
realize about. You controlled to hit the nail upon the highest as well as defined out the entire thing with no need side-effects ,
other people could take a signal. Will likely be again to get more.
Thank you
A financial advisor is your planning associate.
Very good write-up. I certainly appreciate this website.
Stick with it!
Buyers do pay direct and indirect prices.
It’s a pity you don’t have a donate button! I’d most certainly donate to this brilliant blog!
I guess for now i’ll settle for book-marking and adding your RSS
feed to my Google account. I look forward to new updates
and will share this website with my Facebook group. Chat soon!
Investors do pay direct and oblique prices.
I do believe all the ideas you have presented in your post.
They’re really convincing and can certainly work.
Still, the posts are too short for newbies. Could you please extend them a bit from subsequent time?
Thank you for the post.
Great post. I was checking continuously this blog and I am inspired!
Very helpful information specifically the final section :
) I maintain such information much. I used to be looking for this certain info for a very long time.
Thanks and good luck.
It’s perfect time to make some plans for the future and
it’s time to be happy. I have read this post and if I could I desire to suggest you few interesting things or tips.
Maybe you could write next articles referring to this article.
I want to read even more things about it!
Howdy! Do you know if they make any plugins to protect against hackers?
I’m kinda paranoid about losing everything I’ve worked hard on. Any tips?
This piece of writing will assist the internet people for
building up new web site or even a weblog from start to end.
An interesting discussion is worth comment. I do believe that you ought to write more on this topic,
it may not be a taboo subject but typically people don’t talk about
these subjects. To the next! Best wishes!!
I needed to thank you for this great read!! I absolutely enjoyed every bit of it.
I’ve got you saved as a favorite to check out new stuff you post…
This is the right site for anybody who hopes to find out about this topic.
You realize so much its almost hard to argue with you (not that I really will need to…HaHa).
You definitely put a new spin on a subject that’s
been discussed for decades. Excellent stuff, just great!
Now it’s time to decide your specific investments.
Your way of telling everything in this article is genuinely pleasant,
every one be able to without difficulty understand it,
Thanks a lot.
Buyers do pay direct and oblique costs.
And this is an funding risk price taking.
Buyers do pay direct and indirect prices.
And this is an investment danger price taking.
This is true for investment recommendation as nicely.
Now it’s time to decide your particular investments.
A financial advisor is your planning companion.
Thank you on your interest in Funding Advice.
All kinds of investments come with sure dangers.
It’s very effortless to find out any topic on web as compared to textbooks, as I found this paragraph at this web site.
A monetary advisor is your planning accomplice.
This post will help the internet people for setting up new weblog or even a blog from start
to end.
Very nice article, just what I needed.
I’m not sure exactly why but this website is loading very slow for me.
Is anyone else having this issue or is it a issue on my end?
I’ll check back later on and see if the problem still exists.
This site was… how do I say it? Relevant!! Finally I’ve found something
which helped me. Appreciate it!
Its like you read my thoughts! You appear to grasp a lot
about this, like you wrote the ebook in it or something. I feel that you can do with a
few p.c. to pressure the message home a little bit, however other than that, that
is wonderful blog. A great read. I will definitely be back.
Woah! I’m really enjoying the template/theme of this blog.
It’s simple, yet effective. A lot of times it’s tough to get that “perfect balance” between superb usability and visual
appearance. I must say you’ve done a great job with this.
In addition, the blog loads super quick for
me on Safari. Excellent Blog!
Hi! This post couldn’t be written any better!
Reading this post reminds me of my good old room mate!
He always kept talking about this. I will forward this article to him.
Fairly certain he will have a good read. Thank you for sharing!
It’s really a nice and useful piece of information. I am satisfied that you simply shared this useful info with us.
Please stay us up to date like this. Thank you for sharing.
Monetary advisors business is people business.
Do you have any video of that? I’d like to find
out some additional information.
I’m now not positive the place you’re getting your info, however good topic.
I must spend some time learning much more or figuring
out more. Thank you for excellent info I was on the lookout for
this information for my mission.
Thanks designed for sharing such a nice thought, piece of writing is good, thats why i have read it completely
Now it is time to choose your specific investments.
Hi I am so delighted I found your blog page,
I really found you by accident, while I was researching on Aol for something else, Anyhow
I am here now and would just like to say kudos for a marvelous
post and a all round entertaining blog (I also love the theme/design), I don’t have
time to read it all at the minute but I have bookmarked it and also
included your RSS feeds, so when I have time I will be back to read much more, Please do keep up the fantastic work.
I think this is among the most significant information for me.
And i am glad reading your article. But wanna remark on some general things, The site style is perfect, the
articles is really great : D. Good job, cheers
Simply wish to say your article is as astounding.
The clarity on your publish is just spectacular and i could suppose you’re a
professional on this subject. Fine with your permission allow me to take hold of your RSS feed
to stay updated with drawing close post. Thank you 1,000,000 and please carry on the gratifying work.
Hi there! I know this is somewhat off topic but I was wondering
which blog platform are you using for this website?
I’m getting sick and tired of WordPress because I’ve had issues with hackers and
I’m looking at alternatives for another platform.
I would be fantastic if you could point me in the direction of
a good platform.
Hey! This is kind of off topic but I need some guidance from an established blog.
Is it very difficult to set up your own blog? I’m not very
techincal but I can figure things out pretty quick.
I’m thinking about creating my own but I’m not sure where to start.
Do you have any ideas or suggestions? Thank you
A monetary advisor is your planning accomplice.
Financial advisors enterprise is individuals business.
Hmm is anyone else experiencing problems with the pictures on this blog loading?
I’m trying to find out if its a problem on my end or if it’s
the blog. Any feed-back would be greatly appreciated.
That is true for investment advice as effectively.
This info is worth everyone’s attention. Where can I find out more?
Schwab Intelligent Portfolios invests in Schwab ETFs.
This is true for investment recommendation as nicely.
Nice weblog right here! Additionally your web site a lot up
very fast! What web host are you the usage of? Can I get your
associate hyperlink to your host? I desire my site loaded up
as fast as yours lol
It’s going to be end of mine day, however
before finish I am reading this wonderful post to increase my knowledge.
We’re a group of volunteers and starting a new scheme in our community.
Your website provided us with valuable information to work on. You have
done an impressive job and our whole community will be grateful to you.
This is a topic that is close to my heart… Cheers! Exactly where are your contact details
though?
Hey! Would you mind if I share your blog with
my zynga group? There’s a lot of folks that I think
would really appreciate your content. Please let me know.
Thanks
Definitely consider that that you said. Your favourite
reason seemed to be on the web the easiest thing to keep in mind of.
I say to you, I definitely get irked while other folks think about worries that they plainly do not recognize about.
You managed to hit the nail upon the highest as well
as defined out the entire thing with no need side effect , other people could
take a signal. Will likely be again to get more. Thanks
I do believe all of the concepts you’ve introduced in your post.
They are very convincing and will definitely work.
Nonetheless, the posts are very brief for newbies.
May you please lengthen them a little from subsequent
time? Thank you for the post.
Thanks very nice blog!
Hi there, i read your blog from time to time and i own a similar one and i was just wondering if you get a lot of spam feedback?
If so how do you reduce it, any plugin or anything you can recommend?
I get so much lately it’s driving me crazy so any help is
very much appreciated.
Awesome issues here. I’m very satisfied to see your article.
Thanks so much and I’m taking a look forward
to contact you. Will you kindly drop me a mail?
Have you ever considered about adding a little bit more than just your articles?
I mean, what you say is valuable and everything. However imagine if you
added some great photos or video clips to give your posts more, “pop”!
Your content is excellent but with pics and clips,
this website could definitely be one of the very best in its niche.
Superb blog!
And that is an funding danger price taking.
Very descriptive article, I enjoyed that bit. Will there
be a part 2?
Every weekend i used to pay a visit this web site, as i wish for enjoyment,
as this this site conations really fastidious funny information too.
It’s a pity you don’t have a donate button! I’d
without a doubt donate to this outstanding blog! I guess
for now i’ll settle for book-marking and adding
your RSS feed to my Google account. I look forward to
brand new updates and will share this website with my Facebook group.
Talk soon!
Good site you have got here.. It’s hard to find quality writing like yours nowadays.
I honestly appreciate individuals like you! Take care!!
Post writing is also a excitement, if you know afterward you can write otherwise it is complicated to write.
Very rapidly this site will be famous among all blogging people, due to
it’s nice content
What’s up, every time i used to check web site posts here early in the dawn, since i enjoy to gain knowledge
of more and more.
Your way of describing all in this piece of writing is
really fastidious, every one can without difficulty know it, Thanks a lot.
Good day! I could have sworn I’ve been to this website before but after reading through
some of the post I realized it’s new to me. Anyways, I’m definitely happy I found
it and I’ll be bookmarking and checking back
frequently!
I was able to find good info from your articles.
Great blog here! Also your web site loads up very fast!
What host are you using? Can I get your affiliate link to
your host? I wish my site loaded up as fast as yours lol
Hello! I know this is kinda off topic but I was wondering if you knew where I could get a captcha plugin for my comment form?
I’m using the same blog platform as yours and I’m having trouble finding one?
Thanks a lot!
Buyers do pay direct and indirect prices.
Hello mates, its impressive paragraph concerning tutoringand fully defined, keep it up all the time.
Good replies in return of this issue with real arguments and telling
all about that.
It’s really a great and useful piece of information. I’m glad that
you shared this helpful information with us. Please stay us informed like this.
Thanks for sharing.
I have been browsing on-line greater than three hours today, but I never found any attention-grabbing article like yours.
It is lovely worth sufficient for me. Personally, if all site
owners and bloggers made good content as you did, the internet can be much more helpful than ever before.
Hey! Quick question that’s entirely off topic. Do you know how to make your site
mobile friendly? My website looks weird when viewing from my apple iphone.
I’m trying to find a theme or plugin that might be able to resolve this issue.
If you have any suggestions, please share. With thanks!
I was more than happy to discover this site. I want to to thank you for ones time
due to this wonderful read!! I definitely really
liked every part of it and I have you book marked to look at new
stuff in your blog.
All kinds of investments include sure dangers.
Now it is time to pick your specific investments.
Contemplate investments that offer rapid annuities.
Schwab Clever Portfolios invests in Schwab ETFs.
Consider investments that offer fast annuities.
And that is an funding risk worth taking.
A financial advisor is your planning partner.
And this is an investment danger value taking.
Think about investments that provide immediate annuities.
Hi there, I enjoy reading all of your article.
I like to write a little comment to support you.
Hello, Neat post. There’s a problem together with your website in web explorer,
may check this? IE nonetheless is the market chief and a
big portion of folks will omit your fantastic writing
because of this problem.
Today, I went to the beach front with my kids.
I found a sea shell and gave it to my 4 year old daughter and
said “You can hear the ocean if you put this to your ear.”
She placed the shell to her ear and screamed. There
was a hermit crab inside and it pinched her ear.
She never wants to go back! LoL I know this is entirely off topic but I had to tell someone!
Aw, this was an exceptionally good post. Taking the time and actual
effort to produce a really good article… but what
can I say… I procrastinate a lot and never manage to
get anything done.
I couldn’t resist commenting. Perfectly written!
Everything is very open with a clear explanation of the challenges.
It was really informative. Your site is useful.
Many thanks for sharing!
Hello all, here every person is sharing these knowledge,
therefore it’s good to read this webpage, and I used to go to see this web site
everyday.
Spot on with this write-up, I truly believe this website needs
a great deal more attention. I’ll probably be
returning to read more, thanks for the advice!
Greetings! I know this is kinda off topic however I’d figured I’d ask.
Would you be interested in trading links or maybe guest authoring a blog article or
vice-versa? My blog discusses a lot of the same subjects as yours and I think
we could greatly benefit from each other. If you happen to
be interested feel free to send me an email.
I look forward to hearing from you! Excellent blog by the
way!
I really like what you guys tend to be up too.
Such clever work and coverage! Keep up the superb works guys I’ve
included you guys to my own blogroll.
Good site you’ve got here.. It’s hard to find excellent writing like yours these days.
I truly appreciate individuals like you! Take care!!
Hmm is anyone else encountering problems with the pictures on this blog loading?
I’m trying to determine if its a problem on my end or if it’s the blog.
Any suggestions would be greatly appreciated.
What’s Happening i am new to this, I stumbled upon this I’ve found It
absolutely useful and it has helped me out loads.
I hope to give a contribution & help different users
like its helped me. Good job.
They’re certified arborists and employees are insured.
They are certified arborists and employees are insured.
A tree care service may also help to get this dealt
with.
They provide pruning, shaping, cabling and tree care.
They offer pruning, shaping, cabling and
tree care.
They provide pruning, shaping, cabling and tree care.
Great web site. Plenty of useful info here. I’m sending it to
several friends ans also sharing in delicious.
And certainly, thanks in your sweat!
Great energy news, Oregon: following a top 10 energy efficiency rating by @ACEEEdc, we’ve
learned from @energyPNNL that the Beaver State’s residential building code is
rated as 7.5% more energy efficient than the 2018 national model code!