Les patients atteints de fibromyalgie entendent souvent les mots «Tu es si belle. Comment pouvez-vous être malade? »Ou peut-être les mots insensibles« La fibromyalgie est tout dans votre tête ». Recherches en cours et récentes; Cependant, valide la réalité de cette maladie invisible. Cette information permet aux personnes atteintes de fibromyalgie et d’autres maladies invisibles similaires de faire pression au-delà de tout doute et de valider leurs maladies complexes. Plus important encore, la compréhension des recherches récentes aide à orienter et à identifier les choix naturels pour une gestion saine de la douleur associée à la fibromyalgie.
Quelle est l’inflammation?
L’inflammation fait partie du processus de guérison du corps. Sans inflammation, les infections et les plaies ne guériraient pas. Mais l’inflammation peut aussi être potentiellement nocive. Il existe deux types d’inflammation, aiguë et chronique. L’inflammation aiguë survient soudainement à la suite d’une blessure ou d’une infection. Il présente des symptômes classiques tels que gonflement, rougeur et douleur.
L’inflammation aiguë est momentanée, de quelques jours à quelques semaines, selon l’origine de l’inflammation. L’inflammation chronique est une inflammation à long terme qui dure des mois et des années. Cela se fait lentement et ouvre la voie aux maladies chroniques. Les maladies cardiaques, les maladies auto-immunes, les maladies neurologiques, le diabète, le cancer, la maladie d’Alzheimer, l’arthrite et de nombreuses autres affections sont liées à une inflammation chronique.
Les équipes de recherche découvrent une inflammation généralisée dans le cerveau des patients atteints de fibromyalgie
Les études d’imagerie TEP révèlent une activation gliale élevée, corrélation avec les niveaux de fatigue. Une étude a documenté pour la première fois une inflammation généralisée dans le cerveau de patients atteints de la maladie mal comprise appelée fibromyalgie.
Une étude menée par des chercheurs du Massachusetts General Hospital (HGM) – en collaboration avec une équipe du Karolinska Institutet en Suède – a documenté pour la première fois une inflammation généralisée dans le cerveau de patients atteints de la fibromyalgie, une maladie mal comprise. Leur rapport a été publié en ligne dans la revue Brain, Behavior and Immunity .
«Nous n’avons pas de bonnes options de traitement pour la fibromyalgie, donc identifier une cible thérapeutique potentielle pourrait conduire au développement de thérapies innovantes et plus efficaces», a déclaré Marco Loggia, PhD, du Centre Martinos pour l’imagerie biomédicale auteur principal du rapport. “Et trouver des modifications neurochimiques objectives dans le cerveau des patients atteints de fibromyalgie devrait aider à réduire la stigmatisation persistante à laquelle de nombreux patients sont confrontés. On leur dit souvent que leurs symptômes sont imaginaires et qu’il n’y a rien qui ne va pas avec eux.”
L’étude actuelle fournit des preuves d’une liaison élevée à la TSPO, mesurée avec le PET CPBR28, chez les patients atteints de fibromyalgie (FM) par rapport aux témoins sains (HC). Ce marqueur d’activation gliale était augmenté dans plusieurs régions du cerveau impliquées dans la pathologie de la FM par des études de neuroimagerie antérieures. Nous rapportons également des associations positives entre le signal TSPO PET dans plusieurs de ces régions et les évaluations subjectives de la fatigue, l’un des symptômes les plus courants signalés par les patients atteints de FM (Clauw, 2014, Wolfe et al., 2011). Nos observations soutiennent le rôle de l’activation neuroimmune / gliale en pathologie de la FM.
Ces résultats sont conformes à un ensemble de données cliniques suggérant une association possible entre neuroinflammation et FM. Plusieurs études de patients atteints de FM ont mis en évidence des niveaux élevés de LCR dans les molécules impliquées dans la signalisation neurogliale, telles que la fractalkine et l’IL-8.
Fibromyalgie et neuroinflammation
L’inflammation est devenue un sujet de plus en plus important dans la fibromyalgie. Il est clair que la fibromyalgie (et d’autres troubles douloureux chroniques) est une «sensibilisation centrale» – une augmentation de la sensibilité à la douleur provoquée par le système nerveux central. Les facteurs nerveux pro-inflammatoires sont produits par un processus inflammatoire. Ces facteurs nerveux envoient les nerfs producteurs de douleur dans l’état de bouillie et pourraient être à l’origine de cette sensibilisation centrale.
La neuroinflammation est alors une possibilité majeure en FM, mais sa mesure n’a pas été facile. Ce n’est que récemment que des techniques d’imagerie cérébrale ont été développées pour pouvoir mesurer la neuroinflammation présente dans la FM. Cette étude a tenté d’aborder la question de la neuroinflammation de manière différente. Ces dernières années, les différentes cellules du cerveau jouant un rôle dans l’inflammation et l’hypersensibilité ont suscité un intérêt accru.
La microglie est une de ces cellules connue pour jouer un rôle central dans les réponses inflammatoires du cerveau. Le cerveau en a une population assez dense. Mais avant d’examiner plus en détail le rôle de la microglie dans l’inflammation et l’hyper-réaction cérébrales, laissez-nous en apprendre davantage sur l’inflammation et les relations entre les maladies inflammatoires cérébrales et périphériques. Après tout, la FM est généralement provoquée par un problème de santé qui affecte les organes périphériques.
Mécanisme de l’inflammation
L’inflammation est un mécanisme de défense. Une fois que le corps est confronté à un agent infectieux ou à un traumatisme local, il est reconnu et pratiquement consommé (agent infectieux, débris, autre matière étrangère) par les cellules appelées macrophages. Les macrophages jouent également un rôle central dans l’initiation d’une réponse immunitaire, en sécrétant des cytokines et des chimiokines.
Les chimiokines sont les messagers qui attirent d’autres types de cellules défensives dans la région, tandis que les cytokines sont des messagers plus complexes qui envoient des informations sur le stress et l’attaque à diverses cellules et parties du corps. Peu de temps après la réaction inflammatoire initiale, il s’ensuit une maladie qui entraîne une élévation de la température corporelle, une douleur et une perte d’intérêt pour tout ce qui l’entoure.
C’est un moment où nos centres cérébraux entrent en action. Ce sont les centres spécifiques du cerveau qui élèvent la température corporelle afin de contrôler la croissance microbienne (l’augmentation de la température corporelle est un mécanisme de défense régulé). Notre cerveau tente de conserver l’énergie en nous obligeant à nous reposer, à réduire les interactions sociales et les activités physiques.
Nous savons que, quel que soit le lieu de la réponse inflammatoire, le cerveau joue un rôle central dans le contrôle des différentes réponses. Cela soulève la question du mécanisme sous-jacent à l’échange d’informations entre le point d’inflammation (qui peut souvent être éloigné du cerveau) et le cerveau. Cela se produit de deux manières, d’une part, par les messagers appelés cytokines, et d’autre part, par les entrées des nerfs
Traitement pour réduire la neuroinflammation
Nous avons déjà des preuves que des traitements qui réduisent spécialement les niveaux d’inflammation dans le cerveau peuvent atténuer les symptômes de la fibromyalgie. Beaucoup de médicaments que nous considérons comme des anti-inflammatoires (comme l’ibuprofène ou d’autres anti-inflammatoires non stéroïdiens) ne fonctionnent pas bien contre l’inflammation cérébrale, mais certains traitements le permettent. Le naltrexone (LDN) à faible dose est le médicament le plus efficace, mais il est principalement prescrit par les fournisseurs de médecines parallèles, car la plupart des docteurs en médecine occidentale ne sont pas bien connus pour son utilisation contre la douleur.
Un médicament bloquant les opiacés est connu sous le nom de naltrexone. Il est prescrit à doses plus élevées (50 mg) pour traiter la dépendance aux opiacés et à l’alcool. Le LDN réduit l’inflammation dans le système nerveux central lorsqu’il est consommé à de très faibles doses (plage de dosage de 1 à 5 mg).
Il existe des récepteurs spécifiques sur les cellules immunitaires dans le cerveau, appelés cellules gliales, que le LDN agit sur elles et leur dit de retourner en veille prolongée et d’arrêter de libérer des substances chimiques inflammatoires. Dans deux études réalisées à l’Université de Stanford, le LDN a montré une réduction sensible de la douleur liée à la fibromyalgie et une diminution de l’hypersensibilité à la douleur.
Traitement à base de plantes pour traiter l’inflammation
Curcuma: Depuis des centaines d’années, cette épice jaune est utilisée comme anti-inflammatoire en médecine ayurvédique. Le constituant actif est une substance chimique appelée curcumine, dont les recherches ont prouvé qu’elle avait des effets anti-inflammatoires sur le cerveau.
Thé vert: Une substance chimique appelée EGCG (-) – épigallocatéchine-3-gallate s’est révélée être «fortement défensive contre l’inflammation, les dommages oxydatifs et la mort cellulaire» dans le cerveau. Il est extrait du thé vert.
Légumes crucifères: Le sulforaphane est un extrait de brocoli qui protège contre l’inflammation du cerveau et réduit les dommages causés aux neurones.
Les suppléments anti-inflammatoires comprennent:
- >>> acides gras oméga-3
- >>> curcuma >>> gingembre
- >>> coQ10
- >>> rhodiola rosea
De nombreux médecins recommandent un régime anti-inflammatoire pour les affections inflammatoires, mais nous n’avons pas suffisamment de recherche à ce sujet. Les gens commencent souvent avec un régime strictement limité, parce que les déclencheurs inflammatoires de tous ne sont pas les mêmes, puis ajoutent en retour dans un type de nourriture à la fois, pour vérifier quels aliments sont problématiques.
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