Fibromyalgie: une inflammation du cerveau démontrée pour la première fois.

L’inflammation généralisée dans le cerveau des patients atteints de fibromyalgie vient d’être identifiée. Un réel progrès par rapport à cette maladie peu connue et peu reconnue.

Pour la première fois, les chercheurs ont découvert une inflammation généralisée du cerveau chez des patients atteints de fibromyalgie  *  , une maladie peu connue. De quoi développer de nouvelles thérapies Son rapport a été publié dans la revue  Brain, Behavior and Immunity  . “La découverte de modifications neurochimiques objectives dans le cerveau de patients atteints de fibromyalgie devrait aider à réduire la stigmatisation persistante à laquelle font face de nombreux patients. On leur dit souvent que leurs symptômes sont imaginaires et qu’ils n’ont rien “, dit-il. Marco Loggia, directeur de recherche.

Le diagnostic de fibromyalgie reste difficile à établir

La douleur chronique est le principal symptôme de la fibromyalgie. D’autres symptômes (fatigue, troubles du sommeil, perte de mémoire, etc.) diffèrent d’un patient à l’autre et évoluent dans le temps. Malgré l’identification de ces manifestations cliniques, le diagnostic de fibromyalgie reste difficile à établir. À ce jour, aucun examen de laboratoire ou radiologique n’a été en mesure de le confirmer. 

Nous avons analysé 20 patients atteints de fibromyalgie et 14 volontaires de contrôle dans une première équipe. Dans le même temps, un autre groupe de chercheurs avait formé une cohorte de 11 patients et un nombre égal de participants témoins. Les scientifiques ont comparé leurs données pour tirer des conclusions communes.

Activation des cellules gliales dans diverses régions du cerveau.

Finalement, l’activation des cellules gliales dans plusieurs régions du cerveau des patients atteints de fibromyalgie était significativement plus élevée que chez les participants témoins. Dans le système nerveux, les cellules gliales sont les cellules qui forment l’environnement des neurones. “L’activation des cellules gliales que nous avons observée dans nos études libère des médiateurs inflammatoires censés sensibiliser les voies de la douleur et contribuer aux symptômes tels que la fatigue”, conclut Marco Loggia. *

La fibromyalgie touche entre 2 et 5% de la population française, selon l’association Fibromyalgie France, et environ 4 millions d’adultes aux États-Unis. Bien que l’Organisation mondiale de la santé (OMS) ait reconnu la fibromyalgie en tant que maladie en 1992, ce n’est pas encore le cas en France, mais les premiers écrits sur ce syndrome remontent au XVIIIe siècle.

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