Fibromyalgie ist eine mysteriöse Erkrankung, die im ganzen Körper und in tiefen Geweben ohne ersichtlichen Grund Schmerzen verursacht. Ein großer Teil der medizinischen Gemeinschaft hat geglaubt, dass die Krankheit psychosomatisch war, und die Menschen glauben im Wesentlichen, dass sie leiden. Aber ein kleines biopharmazeutisches Unternehmen, Intidyn oder Integrated Tissue Dynamics, hat herausgefunden, was seiner Meinung nach die Ursache der Krankheit ist.
Forscher des Unternehmens und des Albany Medical College fanden heraus, dass in der Haut von Patienten, die Schmerzen aufgrund von Fibromyalgie berichten, eine einzigartige neurovaskuläre Struktur oder ein Blutfluss zu den Nerven besteht. Wissenschaftler glauben, dass dies die ultimative Ursache für die Schmerzen sein kann, die in diesem Zustand auftreten.
“Anstatt sich im Gehirn zu befinden, besteht die Pathologie aus einem Überschuss an sensorischen Nervenfasern um spezialisierte Strukturen von Blutgefäßen in den Handflächen”, sagte Dr. Frank L. Rice, Präsident von Intidyn und der Forscher Hauptstudie in einer Pressemitteilung
Die Verengung der Blutgefäße kann durch die Nerven in der Haut gesteuert werden. Patienten mit Fibromyalgie haben ungewöhnlich viele Nervenenden, die eine Blutgefäßbrücke in der Haut umgeben.
“Diese Entdeckung liefert konkrete Beweise für eine spezifische Pathologie der Fibromyalgie, die jetzt zur Diagnose der Krankheit verwendet werden kann, und als neuer Ausgangspunkt für die Entwicklung wirksamerer Therapien.”
Vor einigen Jahren veröffentlichte das Unternehmen in der Zeitschrift Pain einen Bericht über einen Fall, der sich auf eine Frau bezog, die ohne besondere Nervenenden geboren wurde, die damals als wichtig für den Kontakt angesehen wurden. Aber der Frau ging es gut und sie konnte ihr Leben fortsetzen. Er hatte Nervenenden in der Nähe der dünnen Kapillarblutgefäße in seiner Haut, von denen vorher angenommen wurde, dass sie nur den Blutfluss in den Blutgefäßen steuern. “Früher glaubten wir, dass diese Nervenenden nur an der Regulierung des Blutflusses auf Unterbewusstsein beteiligt sind, aber hier hatten wir Beweise, dass die Enden der Blutgefäße auch zu unserem bewussten Tastsinn beitragen könnten … und auch zu Schmerzen”, sagte Rice. .
Die derzeit von Eli Lilly und Forest Labs hergestellten Zielarzneimittel sind Serotonin / Noradrenalin-Wiederaufnahmehemmer (SNRIs), die im Gehirn wirken. Sie können aber auch auf die Nervenenden in der Nähe der Blutgefäße in der Haut einwirken. “Zu wissen, wie diese Medikamente an Gehirnmolekülen wirken sollten”, fügte Dr. Philip J. Albrecht hinzu, “hatten wir Beweise dafür, dass ähnliche Moleküle an der Funktion von Nervenenden in Blutgefäßen beteiligt waren. . Wir haben daher die Hypothese aufgestellt, dass Fibromyalgie eine Pathologie an diesem Ort beinhalten kann. ” Wie die Ergebnisse zeigen, waren sie richtig.
Das Forschungsteam des Unternehmens untersuchte Hautproben von Frauen mit Fibromyalgie, die vom Albany Medical College gesammelt und mit einer speziellen Mikroskoptechnologie untersucht wurden. Was sie sahen, war eine erstaunliche Zunahme der Nervenenden an der Stelle der Blutgefäße in der Haut. Diese Stellen kontrollieren den Fluss von sauerstoffhaltigem Blut zwischen kleinen Blutgefäßen in der Haut. Sie können dazu führen, dass dieser Bereich der Brücke blockiert wird, damit die Haut Wärme abstrahlen kann, oder geöffnet wird, um sich warm zu halten, wenn es kalt ist.
“Die übermäßige sensorische Innervation kann erklären, warum Patienten mit Fibromyalgie besonders empfindliche und schmerzhafte Hände haben. Da die sensorischen Fasern jedoch für das Öffnen der Shunts verantwortlich sind, werden sie besonders bei Kälte wirksam, die für Patienten mit Fibromyalgie im Allgemeinen sehr ärgerlich ist “, sagte Albrecht.
Aber diese Brücken oder speziellen Shunts regulieren nicht nur die Wärme im Körper. Sie könnten den Blutfluss zu den tiefen Muskeln im Gewebe blockieren.
“Neben der Teilnahme an der Temperaturregulierung fließt normalerweise ein großer Teil unseres Blutflusses zu Händen und Füßen. Viel mehr als das, was für Ihren Stoffwechsel benötigt wird “, sagte Dr. Rice. Als solche fungieren die Hände und Füße als Reservoir, aus dem der Blutstrom zu anderen Körpergeweben geleitet werden kann, beispielsweise zu den Muskeln, wenn wir mit dem Training beginnen. Daher könnte die Pathologie, die zwischen diesen Shunts in den Händen entdeckt wurde, den Blutfluss zu den Muskeln des gesamten Körpers beeinträchtigen. Diese schlecht verabreichte Durchblutung könnte die Ursache für Muskelschmerzen und -schmerzen sein und das Gefühl der Müdigkeit, von dem angenommen wird, dass es sich um eine Ansammlung von Milchsäure und eine geringe Entzündung der Patienten mit Fibromyalgie handelt. Dies wiederum
Eine echte physiologische Grundlage für die Autoimmunerkrankung der Fibromyalgie zu finden, wird für viele eine positive Offenbarung sein, denen gesagt wurde, dass ihre Schmerzen nur im Kopf liegen. Im Laufe der Zeit werden die Forscher in der Lage sein, die Schmerzursachen weiter zu untersuchen und pharmazeutische Produkte zu entwickeln, die die eigentliche Schmerzursache angehen.
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