Fibromyalgie: een voor het eerst aangetoonde ontsteking van de hersenen.

De gegeneraliseerde ontsteking in de hersenen van patiënten met fibromyalgie is net geïdentificeerd. Een echte vooruitgang in relatie tot deze weinig bekende en weinig erkende ziekte.

Voor het eerst ontdekten de onderzoekers een wijdverspreide ontsteking van de hersenen bij patiënten met fibromyalgie  *  , een weinig bekende aandoening. Wat nieuwe therapieën te ontwikkelen Zijn rapport werd gepubliceerd in het tijdschrift  Brain, Behavior and Immunity  . “Het vinden van objectieve neurochemische veranderingen in de hersenen van patiënten met fibromyalgie zou het aanhoudende stigma van veel patiënten moeten helpen verminderen. Ze krijgen vaak te horen dat hun symptomen denkbeeldig zijn en dat ze niets hebben, “zegt hij. Marco Loggia, onderzoeksdirecteur.

De diagnose fibromyalgie blijft moeilijk vast te stellen

Chronische pijn is het belangrijkste symptoom van fibromyalgie. Andere symptomen (vermoeidheid, slaapstoornissen, geheugenverlies, enz.) Verschillen van patiënt tot patiënt en veranderen in de loop van de tijd. Ondanks de identificatie van deze klinische manifestaties, blijft de diagnose fibromyalgie moeilijk vast te stellen. Tot op heden heeft geen enkel laboratorium- of radiologisch onderzoek dit kunnen bevestigen. 

We analyseerden 20 patiënten met fibromyalgie en 14 controlevrijwilligers in een eerste team. Tegelijkertijd had een andere groep onderzoekers een cohort gevormd van 11 patiënten en een gelijk aantal controledeelnemers. De wetenschappers vergeleken hun gegevens om gemeenschappelijke conclusies te trekken.

Activering van gliacellen in verschillende hersengebieden.

Uiteindelijk was de activering van gliacellen in verschillende hersengebieden van patiënten met fibromyalgie significant hoger dan in de controledeelnemers. In het zenuwstelsel zijn gliacellen de cellen die de omgeving van neuronen vormen. “De activering van de gliacellen die we in onze studies waarnamen, maakt ontstekingsmediatoren vrij waarvan wordt gedacht dat ze de pijnpaden sensibiliseren en bijdragen aan symptomen zoals vermoeidheid”, besluit Marco Loggia. *

Fibromyalgie treft tussen 2 en 5% van de Franse bevolking, volgens de vereniging Fibromyalgie France, en ongeveer 4 miljoen volwassenen in de Verenigde Staten. Hoewel de Wereldgezondheidsorganisatie (WHO) fibromyalgie in 1992 erkende als een ziekte, is dit in Frankrijk nog steeds niet het geval, maar de eerste geschriften over dit syndroom werden in de achttiende eeuw gevonden.

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