The generalized inflammation in the brain of patients with fibromyalgia has just been identified. A real progress in relation to this little known and little recognized disease.
For the first time, the researchers discovered a widespread inflammation of the brain in patients with fibromyalgia * , a little-known condition. What to develop new therapies His report was published in the journal Brain, Behavior and Immunity . “Finding objective neurochemical changes in the brain of patients with fibromyalgia should help reduce the persistent stigma faced by many patients. They are often told that their symptoms are imaginary and that they have nothing, “he says. Marco Loggia, Research Director.
The diagnosis of fibromyalgia remains difficult to establish
Chronic pain is the main symptom of fibromyalgia. Other symptoms (fatigue, sleep disturbances, memory loss, etc.) differ from one patient to another and change over time. Despite the identification of these clinical manifestations, the diagnosis of fibromyalgia remains difficult to establish. To date, no laboratory or radiological examination has been able to confirm this.
We analyzed 20 patients with fibromyalgia and 14 control volunteers in a first team. At the same time, another group of researchers had formed a cohort of 11 patients and an equal number of control participants. The scientists compared their data to draw common conclusions.
Activation of glial cells in various regions of the brain.
In the end, the activation of glial cells in several regions of the brain of patients with fibromyalgia was significantly higher than in the control participants. In the nervous system, glial cells are the cells that form the environment of neurons. “The activation of the glial cells that we observed in our studies releases inflammatory mediators that are thought to sensitize the pain pathways and contribute to symptoms such as fatigue,” concludes Marco Loggia. *
Fibromyalgia affects between 2 and 5% of the French population, according to the Fibromyalgie France association, and around 4 million adults in the United States. Although the World Health Organization (WHO) recognized fibromyalgia as a disease in 1992, this is still not the case in France. However, the first writings on this syndrome were found in the eighteenth century.