Fibromyalgi har vært en mystisk sykdom som forårsaker smerte i hele kroppen og i dype vev uten tilsynelatende årsak. En stor del av det medisinske samfunnet har trodd at sykdommen var psykosomatisk, og folk tror i hovedsak at de lider. Men et lite biofarmaceutisk selskap, Intidyn eller Integrated Tissue Dynamics, har oppdaget hva de mener er årsaken til sykdommen.
Forskere fra selskapet og Albany Medical College oppdaget at det er en unik nevrovaskulær struktur, eller blodstrøm til nerver, i huden til pasienter som rapporterer smerte fra fibromyalgi. Dette, tror forskere, kan være den ultimate årsaken til smerten som oppleves i tilstanden.
“I stedet for å være i hjernen, består patologien av et overskudd av sensoriske nervefibre rundt spesialiserte strukturer av blodkar som ligger i håndflatene,” sa Dr. Frank L. Rice, president for Intidyn og forskeren hovedstudie, i en pressemelding
Konstruksjonen av blodårene kan styres av nerver i huden. Pasienter med fibromyalgi har et unormalt høyt antall nerveender som omgir en bro av blodkar i huden.
“Denne oppdagelsen gir konkrete bevis på en spesifikk patologi for fibromyalgi som nå kan brukes til å diagnostisere sykdommen, og som et nytt utgangspunkt for å utvikle mer effektive terapier.”
For noen år siden publiserte selskapet en rapport i magasinet Pain om et tilfelle relatert til en kvinne som ble født uten spesielle nerveender som på den tiden ble ansett som viktig for kontakt. Men kvinnen var bra og kunne fortsette med livet hennes. Han hadde nerveender nær de tynne kapillære blodkarene i huden, som tidligere var ment å bare kontrollere blodstrømmen i blodkarene. “Tidligere trodde vi at disse nerveendene var bare involvert i reguleringen av blodstrøm på den underbevisst nivå, men her hadde vi bevis for at avslutninger av blodkar kan også bidra til vår bevisste følelse av kontakt … og smerte , ” sa Rice .
Aktuelle målrettede medikamenter, fremstilt ved Eli Lilly and Forest Labs, er hemmere av serotonin-reopptak / noradrenalin (SNRI) som arbeider i hjernen. Men de kan også fungere på nerveenden nær blodkarene i huden. “Å vite hvordan disse stoffene jobbet ment molekyler i hjernen,” sier Dr. Philip J. Albrecht, Ph.D., “vi hadde bevis for at lignende molekyler var involvert i funksjon av nerveender i blodkar . Derfor antydet vi at fibromyalgi kan innebære en patologi på den plasseringen. ” Som resultatene viser, var de korrekte.
Selskapets forskningsteam undersøkte hudprøver fra kvinner med fibromyalgi samlet av Albany Medical College og undersøkt av spesiell mikroskopteknologi. Det de så, var en fantastisk økning i nerveenden på stedet for blodkarene i huden. Disse områdene kontrollerer strømmen av oksygenert blod mellom små blodkar i huden. De kan forårsake blokkering av dette området av broen slik at huden kan utstråle varme eller åpne den for å holde varmen når den er kald.
“Overskuddet av sensorisk innervering kan forklare hvorfor pasienter med fibromyalgi har en tendens til å ha spesielt følsomme og smertefulle hender. Men siden sensoriske fibre er ansvarlige for å åpne skuddene, blir de spesielt aktive i kalde forhold, som generelt er svært irriterende for pasienter med fibromyalgi, sier Albrecht.
Men disse broene eller spesielle shunts gjør mye mer enn å regulere varmen i kroppen; de kan blokkere blodstrømmen til de dype musklene i vevet.
“I tillegg til å delta i regulering av temperatur, går en stor del av blodstrømmen vår til våre hender og føtter. Mye mer enn det som trengs for stoffskiftet ditt, “sa Dr. Rice. “Som sådan fungerer hendene og føttene som et reservoar hvorfra blodstrømmen kan viderekobles til andre vev i kroppen, for eksempel muskler når vi begynner å trene. Derfor kan patologien som oppdages mellom disse shunts i hendene, forstyrre blodstrømmen til kroppens muskler. Denne dårlig administrerte blodstrømmen kan være kilden til muskelsmerter og smerte, og følelsen av tretthet som antas å skyldes akkumulering av melkesyre og lave nivåer av betennelse hos pasienter med fibromyalgi. Dette i sin tur
Å finne et ekte fysiologisk grunnlag for den autoimmune sykdommen av fibromyalgi vil være en positiv åpenbaring for mange som har blitt fortalt at deres smerte bare er i hodet. Over tid vil forskere kunne videreoppdage årsakene til smerte i sykdommen og kan utvikle farmasøytiske produkter for å håndtere den virkelige årsaken til smerte.
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