Fibromialgie word vir die eerste keer aan dermbakterieë gekoppel

Wetenskaplikes het ‘n skakel gevind tussen ‘n siekte waarby chroniese pyn betrokke is en veranderinge in die dermmikrobioom.

Fibromialgie affekteer 2-4 persent van die bevolking en het geen bekende genesing nie. Simptome sluit in moegheid, verswakte slaap en kognitiewe probleme, maar die siekte word die duidelikste gekenmerk deur wydverspreide chroniese pyn. In ‘n artikel wat vandag in die vaktydskrif Pain gepubliseer is, het ‘n navorsingspan wat in Montreal gebaseer is, vir die eerste keer getoon dat daar veranderinge in die bakterieë in die spysverteringskanaal is van mense met fibromialgie. Ongeveer 20 verskillende soorte bakterieë word in die mikrobioom aangetref van deelnemers wat aan die siekte ly in groter of mindere verhoudings as in die gesonde kontrolegroep.

Groter teenwoordigheid of afwesigheid van sekere soorte bakterieë 

“Ons het ‘n verskeidenheid tegnieke gebruik, insluitend kunsmatige intelligensie, om te bevestig dat die veranderinge wat ons in die mikrobioom van fibromialgie-pasiënte gesien het, nie veroorsaak is deur faktore soos dieet, medikasie, liggaamlike aktiwiteit, ouderdom, ens. Dat dit ‘n invloed het op die mikrobioom, ”sê dr. Amir Minerbi, van die Alan Edwards Pain Management Unit by die McGill University Health Centre (MUHC), en die eerste skrywer op die papier. Die span het ook navorsers van die McGill-universiteit en Université de Montréal, sowel as ander van die MUHC-navorsingsinstituut, ingesluit.

Dr Minerbi voeg by: ‘Ons het gevind dat fibromialgie en die simptome van fibromialgie – pyn, moegheid en kognitiewe probleme – meer as enige van die ander faktore bydra tot die variasies wat ons sien in die mikrobioom van diegene met die siekte. Ons het ook gesien dat die erns van die simptome van die pasiënt direk gekorreleer is met ‘n groter teenwoordigheid of ‘n duideliker afwesigheid van sekere bakterieë – iets wat nog nooit tevore gerapporteer is nie. ‘

Is bakterieë bloot die merkers van die siekte?

Op hierdie stadium is dit nie duidelik of die veranderinge in die dermbakterieë wat by pasiënte met fibromialgie gesien word, bloot merkers van die siekte is nie, of dat dit ‘n rol speel om dit te veroorsaak nie. Aangesien die siekte ‘n groep simptome behels, en nie net pyn nie, is die volgende stap in die navorsing om te ondersoek of daar soortgelyke veranderinge in die dermmikrobioom is onder ander toestande wat chroniese pyn insluit, soos onderrugpyn, hoofpyn en neuropatiese pyn. . . .

Die navorsers is ook geïnteresseerd in die ondersoek of bakterieë ‘n oorsaaklike rol speel in die ontwikkeling van pyn en fibromialgie. Of hul teenwoordigheid uiteindelik kan help met die opsporing van medisyne en die diagnoseproses kan bespoedig.

Bevestig ‘n diagnose en die volgende stappe na genesing

Fibromialgie is ‘n siekte wat moeilik is om te diagnoseer. Pasiënte kan so lank as 4 tot 5 jaar wag om ‘n finale diagnose te kry. Maar dit kan op die punt wees om te verander.

“Ons het groot hoeveelhede data gesorteer en 19 spesies geïdentifiseer wat toegeneem of afgeneem het by individue met fibromialgie,” sê Emmanuel Gonzalez, van die Kanadese sentrum vir berekeningsgenomika en die departement menslike genetika aan die McGill-universiteit. “Met behulp van masjienleer kon ons rekenaar diagnose maak van fibromialgie, gebaseer op die mikrobiomsamestelling, met ‘n akkuraatheid van 87 persent. Terwyl ons voortbou op hierdie eerste ontdekking met meer navorsing, hoop ons om hierdie akkuraatheid te verbeter en moontlik ‘n stapverandering in diagnose te bewerkstellig. “

“Mense met fibromialgie ly nie net aan die simptome van hul siekte nie, maar ook aan die probleme van familie, vriende en mediese spanne om hul simptome te verstaan,” sê Yoram Shir, die senior skrywer in die koerant wat Alan Edwards Pain aanvoer. Bestuurseenheid by die MUHC en ‘n mede-ondersoeker van die BRaiN-program van die RI-MUHC. “As pynpraktisyns is ons gefrustreerd oor ons onvermoë om te help, en hierdie frustrasie is ‘n goeie brandstof vir navorsing. Dit is die eerste bewys, ten minste by mense, dat die mikrobioom ‘n invloed kan hê op diffuse pyn, en dat ons regtig nuwe maniere nodig het om na chroniese pyn te kyk. ‘

Hoe die navorsing gedoen is

Die navorsing is gebaseer op ‘n groep van 156 individue in die Montreal-omgewing, waarvan 77 aan fibromialgie ly. Deelnemers aan die studie is ondervra en monsters van ontlasting, bloed, speeksel en urine gegee, wat dan vergelyk word met dié van gesonde kontrolepersone, waarvan sommige in dieselfde huis gewoon het as die fibromialgie-pasiënte, of hul ouers, kinders of broers en susters.

Die volgende stappe van die navorsers is om te sien of hulle soortgelyke resultate in ‘n ander kohort, miskien in ‘n ander wêrelddeel, kry, en om diere te ondersoek om vas te stel of veranderinge in bakterieë ‘n rol speel in die ontwikkeling van die siekte.

Hierdie artikel is herpubliseer uit die volgende materiale. Opmerking: Materiaal is moontlik geredigeer vir lengte en inhoud. Kontak die aangehaalde bron vir verdere inligting.

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