EVIDENCIA DE DAÑO NERVIOSO EN APROXIMADAMENTE LA MITAD DE LOS PACIENTES CON FIBROMIALGIA

Resumen: Aproximadamente la mitad de un pequeño grupo de pacientes con fibromialgia – se encontró que tienen daño a las fibras nerviosas en la piel y otras pruebas de una enfermedad llamada polineuropatía de fibras pequeñas (SFPN) – un síndrome común que causa dolor crónico y otros síntomas. A diferencia de la fibromialgia, SFPN tiene una patología clara y se sabe que es causada por las condiciones médicas específicas, algunas de las cuales pueden ser tratadas y, a veces curado.

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Se encontró que tenía daños en las fibras nerviosas en la piel y otras evidencias de una enfermedad llamada polineuropatía de fibras pequeñas (SFPN) – Alrededor de la mitad de un pequeño grupo de pacientes con fibromialgia – un síndrome común que causa dolor crónico y otros síntomas. A diferencia de la fibromialgia, que no ha tenido causas conocidas y pocos tratamientos eficaces, SFPN tiene una patología clara y se sabe que es causada por condiciones médicas específicas, algunas de las cuales pueden ser tratadas y curadas veces. El estudio del Massachusetts General Hospital (MGH), los investigadores aparecerá en la revista  PAIN  y ha sido puesto en libertad en línea.

“Esto proporciona algunas de las primeras evidencias objetivas de un mecanismo detrás de algunos casos de fibromialgia, y la identificación de una causa subyacente es el primer paso hacia la búsqueda de mejores tratamientos”, dice Anne Louise Oaklander, MD, PhD, director de la Unidad de Lesión del nervio en el Departamento de Neurología MGH y autor correspondiente del papel del dolor.

El término fibromialgia se describe un conjunto de síntomas – incluyendo dolor crónico generalizado, aumento de la sensibilidad a la presión y la fatiga – que se cree que afecta a 1 a 5 por ciento de las personas en los países occidentales, más frecuentemente a las mujeres. Mientras que un diagnóstico de la fibromialgia ha sido reconocido por los Institutos Nacionales de Salud y el Colegio Americano de Reumatología, su base biológica ha permanecido desconocido. comparte muchos síntomas de la fibromialgia con SFPN, una causa reconocida de dolor crónico generalizado para los que no son aceptados, las pruebas objetivas.

Diseñado para investigar las posibles conexiones entre las dos condiciones, el estudio actual inscrito 27 pacientes adultos con diagnóstico de fibromialgia y 30 voluntarios sanos. Los participantes pasaron por una serie de pruebas para diagnosticar la SFPN, incluidas las evaluaciones de la neuropatía en base a un examen físico y las respuestas a un cuestionario, biopsias de piel para evaluar el número de fibras nerviosas en sus extremidades inferiores, y las pruebas de las funciones autonómicas como la frecuencia cardíaca , la presión arterial y la sudoración.

Los cuestionarios, evaluaciones y exámenes, biopsias de piel toda encontraron niveles significativos de neuropatía en los pacientes con fibromialgia, pero no en el grupo de control. De los 27 pacientes con fibromialgia, 13 tenían una marcada reducción en la densidad de la fibra nerviosa, pruebas de función autonómica anormales o ambos, lo que indica la presencia de SFPN. Los participantes que cumplían los criterios para SFPN también se sometieron a análisis de sangre para las causas conocidas de la enfermedad, y aunque ninguno de ellos tuvo resultados sugestivos de la diabetes, se encontró una causa común de SFPN, dos para tener infección por el virus de la hepatitis C, que pueden ser tratados con éxito, y más de la mitad tenían evidencia de algún tipo de disfunción del sistema inmune.

“Hasta ahora, no ha habido una buena idea sobre lo que causa la fibromialgia, pero ahora tenemos pruebas para algunos, pero no todos los pacientes. La fibromialgia es demasiado complejo para una ‘talla única’ explicación “, dice Oaklander, profesor asociado de neurología de la Facultad de Medicina de Harvard. “El siguiente paso de confirmación independiente de los hallazgos de otros laboratorios ya está ocurriendo, y también tenemos que seguir aquellos pacientes que no cumplieron los criterios SFPN para ver si podemos encontrar otras causas.Ayudar a cualquiera de estas personas reciben un diagnóstico definitivo y un mejor tratamiento sería un gran logro “.

Historia de Fuente:

materiales

proporcionada por  el Hospital General de Massachusetts . Nota: El contenido puede ser editado por el estilo y longitud.

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