Como os danos nos nervos desempenham um papel na fibromialgia. Estudo recente

Em um estudo recente de pacientes que sofrem de fibromialgia, quase metade dos pacientes teve danos moderados a graves em suas células da pele.

Danos ao nervo causado fibras nervosas tem sido considerado polineuropatia de fibra pequena ou SFPN. A polineuropatia de fibras pequenas é causada por algumas condições médicas específicas.

Atualmente, não há nenhuma causa conhecida de fibromialgia, então esta descoberta de danos nos nervos poderia fazer algum progresso em encontrar exatamente o que causa o distúrbio.

Os distúrbios da fibromialgia diferenciam o paciente do paciente, mas os sintomas típicos incluem dor generalizada crônica, fadiga extrema e hipersensibilidade à dor e à pressão. O distúrbio afeta desproporcionalmente as mulheres em comparação aos homens.

Olhando para os danos nos nervos

Algum progresso foi feito sobre como diagnosticar corretamente o distúrbio, mas sua patologia permanece um mistério. A fibromialgia tem alguns dos mesmos sintomas que a polineurotherapy de fibra pequena porque a polineurotherapy de fibra pequena causou dor crônica generalizada em pessoas que foram diagnosticadas com ela.

O estudo foi conduzido em 27 adultos com transtorno de fibromialgia e um grupo de 30 pessoas saudáveis ​​que se ofereceram para o estudo. Os mesmos testes utilizados nos diagnósticos de polineurotrofina de pequenas fibras foram utilizados para avaliar os participantes do estudo. Os testes incluíram um exame físico e a administração de um questionário.

Além disso, pesquisas administradas biópsias de pele ajudam na avaliação das fibras nervosas nas pernas dos pacientes e no controle da pressão arterial, sudorese e frequência cardíaca dos pacientes.

A neuropatia foi encontrada em contagens muito altas em pacientes com fibromialgia, enquanto o grupo de indivíduos saudáveis ​​parecia normal. Treze dos 27 pacientes com fibromialgia foram registrados como indivíduos com níveis reduzidos de densidade de fibras nervosas na pele.

Aqueles cerca de treze pessoas também tiveram resultados estranhos do teste de função autônoma. Devido a estes resultados, presumiu-se que estes treze indivíduos tinham polineuroterapia de fibra pequena.

Embora as conclusões tiradas desse teste não sugiram uma causa no desenvolvimento de todas as condições da fibromialgia, ele fornece aos pesquisadores algumas evidências sobre o que causa a fibromialgia em pelo menos alguns pacientes.

Transtorno de fibromialgia é um transtorno muito complexo, único e complexo. Seus sintomas e gravidade são diferentes em cada paciente que afeta. Devido a esta diferenciação única, não há uma única explicação para o desenvolvimento da fibromialgia.

Esse processo pode levar meses ou anos até que as respostas sejam encontradas sobre quais são as principais causas da fibromialgia. Antes que você possa trabalhar na cura da fibromialgia, os pesquisadores devem primeiro descobrir o que exatamente causa o distúrbio nos pacientes.

Este estudo é atualmente o único desse tipo. Os resultados foram publicados recentemente para que outros laboratórios em breve comecem a criar seus próprios testes e experimentos de acordo com o modelo que este estudo elaborou.

Alguns já podem ter começado com algumas adaptações. A busca por um melhor diagnóstico da fibromialgia é contínua.

E encontrar melhores tratamentos para as pessoas que foram infligidas pelo distúrbio da fibromialgia é uma das principais prioridades quando se trata deste distúrbio único.

Evidência de danos nos nervos em aproximadamente metade dos pacientes com fibromialgia

Resumo: Cerca de metade de um pequeno grupo de pacientes com fibromialgia, uma síndrome comum que causa dor crônica e outros sintomas, apresentou danos na fibra nervosa da pele e outras evidências de uma doença chamada polineuropatia de fibras finas (SFPN). ). Ao contrário da fibromialgia, a SFPN tem uma patologia clara e é conhecida por ser causada por condições médicas específicas, algumas das quais podem ser tratadas e, às vezes, curadas.

Cerca de metade de um pequeno grupo de pacientes com fibromialgia, uma síndrome comum que causa dor crônica e outros sintomas, foi encontrado para ter danos à fibra nervosa da pele e outras evidências de uma doença chamada polineuropatia de fibras pequenas (SFPN). . Ao contrário da fibromialgia, que não teve causas conhecidas e poucos tratamentos eficazes, a SFPN tem uma patologia clara e é conhecida por ser causada por condições médicas específicas, algumas das quais podem ser tratadas e, por vezes, curadas. O estudo realizado pelo Massachusetts General Hospital (MGH) pesquisadores aparecerá na revista DOLOR e foi publicado online.

“Isso fornece parte da primeira evidência objetiva de um mecanismo por trás de alguns casos de fibromialgia, e a identificação de uma causa subjacente é o primeiro passo para encontrar melhores tratamentos”, diz Anne Louise Oaklander, MD, PhD, diretor da Unidade de Lesões Nervosas. no Departamento de Neurologia do MGH e autor correspondente do artigo Pain.

O termo fibromialgia descreve uma série de sintomas, incluindo dor crônica generalizada, aumento da sensibilidade à pressão e à fadiga, que, acredita-se, afeta 1 a 5% das pessoas nos países ocidentais, mais frequentemente nas mulheres. Embora os Institutos Nacionais de Saúde e o Colégio Americano de Reumatologia tenham reconhecido o diagnóstico de fibromialgia, sua base biológica permanece desconhecida. A fibromialgia compartilha muitos sintomas com SFPN, uma causa reconhecida de dor generalizada crônica para a qual testes objetivos são aceitos.

Projetado para investigar possíveis conexões entre as duas condições, o estudo atual envolveu 27 pacientes adultos com diagnóstico de fibromialgia e 30 voluntários saudáveis. Os participantes passaram por uma bateria de testes usados ​​para diagnosticar SFPN, incluindo avaliações de neuropatia com base em um exame físico e respostas a um questionário, biópsias de pele para avaliar o número de fibras nervosas na parte inferior das pernas e testes de funções autonômicas, como a freqüência cardíaca , pressão arterial e sudorese.

Os questionários, avaliações de exames e biópsias de pele encontraram níveis significativos de neuropatia em pacientes com fibromialgia, mas não no grupo controle. Dos 27 pacientes com fibromialgia, 13 tiveram uma redução acentuada na densidade das fibras nervosas, testes de função autonômica anormal ou ambos, indicando a presença de SFPN. Os participantes que preencheram os critérios para SFPN também foram submetidos a exames de sangue para causas conhecidas do distúrbio, e embora nenhum deles tivesse resultados sugestivos de diabetes, uma causa comum de SFPN, dois foram encontrados para ser infectado com o vírus da hepatite. C, que pode ser tratado com sucesso. e mais da metade tinha evidências de algum tipo de disfunção do sistema imunológico.

“Até agora, não houve uma boa idéia sobre o que causa a fibromialgia, mas agora temos evidências para alguns, mas não para todos os pacientes.” A fibromialgia é muito complexa para uma explicação do tipo “tamanho único”, diz Oaklander. professor associado de neurologia na Harvard Medical School. “O próximo passo de confirmação independente de nossas descobertas em outros laboratórios já está acontecendo, e também devemos seguir aqueles pacientes que não atenderam aos critérios da SFPN para ver se podemos encontrar outras causas. Ajudar qualquer uma dessas pessoas a receber diagnósticos definitivos e melhor tratamento seria uma grande conquista. “

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