Cómo el daño a los nervios juega un papel en la fibromialgia. Estudio realizado recientemente

De: lisa martin

En un estudio reciente de pacientes con fibromialgia, se observó daño nervioso moderado a grave en las células de la piel en casi la mitad de los pacientes.

El daño a los nervios de las fibras nerviosas se consideró una polineuropatía de fibras pequeñas o SFPN. La polineuropatía de fibra pequeña es causada por algunas enfermedades específicas.

Actualmente no hay una causa conocida para la fibromialgia, por lo que este descubrimiento de daño a los nervios podría hacer algún progreso hacia la búsqueda de qué causa exactamente el trastorno.

Los trastornos de la fibromialgia distinguen a los pacientes de un paciente a otro, pero los síntomas típicos incluyen dolor crónico generalizado, fatiga extrema y hipersensibilidad al dolor y la presión. El trastorno afecta a las mujeres de manera desproporcionada en comparación con los hombres.

Considera el daño nervioso

Se ha avanzado algo en el diagnóstico correcto del trastorno, pero su patología sigue siendo un misterio. La fibromialgia tiene algunos de los mismos síntomas que la polineuroterapia de fibra pequeña, en la cual la polineuroterapia de fibra pequeña ha provocado un dolor crónico generalizado en las personas diagnosticadas.

El estudio se realizó en 27 adultos con el trastorno de fibromialgia y en un grupo de 30 voluntarios sanos que se ofrecieron como voluntarios para el estudio. Las mismas pruebas utilizadas en los diagnósticos de polineuroterapia de fibra pequeña se utilizaron para evaluar a los participantes en el estudio. Las pruebas incluyeron un examen físico y la gestión de un cuestionario.

Además, los investigadores administraron biopsias de piel para ayudar a evaluar las fibras nerviosas en las piernas de los pacientes y controlar la presión arterial, la sudoración y la frecuencia cardíaca del paciente.

La neuropatía se encontró en números muy altos en pacientes con fibromialgia, mientras que el grupo de individuos sanos parecía normal. Trece de los 27 pacientes con fibromialgia se registraron como individuos con densidad reducida de fibras nerviosas en su piel.

Los aproximadamente trece individuos también tuvieron resultados impares de pruebas funcionales autónomas. En base a estos resultados, se asumió que estos trece sujetos tenían una polineuroterapia de fibra pequeña.

Aunque las conclusiones extraídas de esta prueba sugieren que no hay causa para el desarrollo de todas las afecciones de la fibromialgia, dan algunas pistas a los investigadores, que en algunos pacientes causan la fibromialgia.

El trastorno de la fibromialgia es un trastorno muy complejo, único y complejo. Sus síntomas y severidad son diferentes para cada paciente afectado. Debido a esta diferenciación única, no hay explicación para el desarrollo de la fibromialgia.

Este proceso puede llevar meses o años para encontrar respuestas, que son las causas principales de la fibromialgia. Antes de trabajar en una cura para la fibromialgia, los investigadores primero deben averiguar exactamente qué causa el desarrollo del trastorno en los pacientes.

Este estudio es actualmente único. Los resultados se publicaron recientemente, por lo que otros laboratorios pronto deberían comenzar a realizar sus propias pruebas y experimentos después del diseño de este estudio.

Es posible que algunos ya hayan comenzado con algunos ajustes. Encontrar un mejor diagnóstico de fibromialgia es un proceso continuo.

Y encontrar mejores tratamientos para aquellas personas causadas por el trastorno de fibromialgia es una de las principales prioridades cuando se trata de este trastorno único.

Evidencia de daño a los nervios en aproximadamente la mitad de los pacientes con fibromialgia

Resumen: alrededor de la mitad de un pequeño grupo de pacientes con fibromialgia, un síndrome común que causa dolor crónico y otros síntomas, han sido diagnosticados con daños en las fibras nerviosas de la piel y otros signos de una afección conocida como polineuropatía de fibras pequeñas (SFPN) , A diferencia de la fibromialgia, la SFPN tiene una patología distinta y se sabe que es causada por afecciones médicas específicas, algunas de las cuales se pueden tratar y algunas veces curar.

Alrededor de la mitad de un pequeño grupo de pacientes con fibromialgia, un síndrome común que causa dolor crónico y otros síntomas, han sido diagnosticados con daño a las fibras nerviosas en su piel y otros signos de una afección llamada polineuropatía de fibra pequeña (SFPN). A diferencia de la fibromialgia, que no tuvo causas conocidas y pocos tratamientos efectivos, la SFPN tiene una patología clara y se sabe que es causada por ciertas afecciones médicas, algunas de las cuales pueden tratarse y, a veces, curarse. El estudio realizado por investigadores del Hospital General de Massachusetts (MGH) aparecerá en la revista PAIN y se publicó en línea.

“Esto proporciona algunas de las primeras pruebas objetivas de un mecanismo detrás de algunos casos de fibromialgia, y la identificación de una causa subyacente es el primer paso para encontrar mejores tratamientos”, dice Anne Louise Oaklander, MD, PhD, directora de la Unidad de lesiones nerviosas en el Departamento de Neurología MGH y correspondiente pintor del dolor.

El término fibromialgia describe una gama de síntomas, entre los que se incluyen el dolor crónico y generalizado, el aumento de la hipersensibilidad y la fatiga, que se cree que afectan del 1 al 5 por ciento de los occidentales, más comúnmente las mujeres. Si bien un diagnóstico de fibromialgia ha sido reconocido por los Institutos Nacionales de la Salud y el Colegio Americano de Reumatología, su base biológica sigue siendo desconocida. La fibromialgia comparte muchos síntomas con SFPN, una causa reconocida de dolor crónico y generalizado para el cual existen pruebas objetivas.

Para investigar la posible relación entre las dos enfermedades, 27 pacientes adultos con diagnóstico de fibromialgia y 30 voluntarios sanos se incluyeron en el estudio actual. Los participantes se sometieron a una serie de pruebas para diagnosticar SFPN, que incluyen neuropatía de un examen físico y respuestas a cuestionarios, biopsias de piel para determinar el número de fibras nerviosas en la parte inferior de las piernas y pruebas de funciones autónomas como la frecuencia cardíaca, la presión arterial y la sudoración.

Los cuestionarios, la evaluación de los exámenes y las biopsias de piel mostraron valores significativos de neuropatía en los pacientes con fibromialgia, pero no en el grupo control. De los 27 pacientes con fibromialgia, 13 tuvieron una disminución marcada en la densidad de la fibra nerviosa, pruebas de función autónoma anormales, o ambas, lo que indica la presencia de SFPN. Los participantes que cumplieron con los criterios para SFPN también fueron evaluados para detectar causas conocidas de la enfermedad, y aunque ninguno de ellos tenía evidencia de diabetes, una causa común de SFPN, dos encontraron una infección por el virus de la hepatitis C que se puede tratar con éxito , y más de la mitad tenía signos de algún tipo de disfunción del sistema inmunológico.

“Hasta ahora, no se ha tenido una buena idea de qué causa la fibromialgia, pero ahora tenemos evidencia de algunos, pero no de todos los pacientes. La fibromialgia es demasiado compleja para una explicación de “talla única”, dice Oaklander, profesor asociado de neurología en la Escuela de Medicina de Harvard. “El siguiente paso de validar de forma independiente nuestros hallazgos de otros laboratorios ya está en marcha, y también debemos hacer un seguimiento de los pacientes que no cumplen con los criterios de SFPN para ver si podemos encontrar otras causas. Ayudar a una de estas personas a obtener un diagnóstico definitivo y un mejor tratamiento sería un gran logro. “

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