Comment les lésions nerveuses jouent un rôle dans la fibromyalgie. Étude récente

Dans une étude récente sur des patients souffrant de fibromyalgie, près de la moitié des patients présentaient des lésions modérées à sévères de leurs cellules cutanées.

Les dommages causés aux fibres nerveuses ont été considérés comme une polyneuropathie des petites fibres ou SFPN. La polyneuropathie à petites fibres est causée par certaines conditions médicales spécifiques.

Actuellement, il n’y a pas de cause connue de la fibromyalgie, donc cette découverte de lésions nerveuses pourrait faire quelques progrès dans la recherche de ce qui cause le trouble.

Les troubles de la fibromyalgie différencient le patient du patient, mais les symptômes typiques incluent une douleur chronique généralisée, une fatigue extrême et une hypersensibilité à la douleur et à la pression. La maladie affecte de manière disproportionnée les femmes par rapport aux hommes.

En regardant les lésions nerveuses

Certains progrès ont été réalisés sur la façon de diagnostiquer correctement le trouble, mais sa pathologie reste un mystère. La fibromyalgie présente certains des mêmes symptômes que la polyneurothérapie à petites fibres, car la polynévrothérapie à petites fibres a causé une douleur chronique généralisée chez les personnes qui en ont été diagnostiquées.

L’étude a été menée sur 27 adultes avec le trouble de la fibromyalgie et un groupe de 30 personnes en bonne santé qui s’étaient portées volontaires pour l’étude. Les mêmes tests utilisés dans les diagnostics de polyneurothérapie de petites fibres ont été utilisés pour évaluer les participants à l’étude. Les tests comprenaient un examen physique et l’administration d’un questionnaire.

En outre, les recherches administrées biopsies cutanées aident à l’évaluation des fibres nerveuses dans les jambes des patients et le contrôle de la pression artérielle, la transpiration et la fréquence cardiaque des patients.

La neuropathie a été trouvée dans les comptes très élevés chez les patients atteints de fibromyalgie, tandis que le groupe d’individus en bonne santé semblait normal. Treize des 27 patients atteints de fibromyalgie ont été enregistrés en tant qu’individus avec des niveaux réduits de densité de fibres nerveuses dans la peau.

Ceux d’environ treize personnes ont également eu des résultats étranges du test de fonction autonome. En raison de ces résultats, il a été supposé que ces treize individus avaient une polyneurothérapie de petite taille.

Bien que les conclusions tirées de ce test ne suggèrent pas une cause dans le développement de toutes les conditions de la fibromyalgie, il fournit aux chercheurs des preuves sur les causes de la fibromyalgie chez au moins certains patients.

Le trouble de la fibromyalgie est un trouble très complexe, unique et complexe. Ses symptômes et sa gravité sont différents chez chaque patient. En raison de cette différenciation unique, il n’y a pas une seule explication pour le développement de la fibromyalgie.

Ce processus pourrait prendre des mois ou des années avant que des réponses soient trouvées sur les causes principales de la fibromyalgie. Avant que vous puissiez travailler sur la guérison de la fibromyalgie, les chercheurs doivent d’abord savoir ce qui cause exactement le trouble chez les patients.

Cette étude est actuellement unique en son genre. Les résultats ont été publiés récemment afin que d’autres laboratoires commencent bientôt à créer leurs propres tests et expériences selon le modèle que cette étude a élaboré.

Certains peuvent déjà avoir commencé avec quelques adaptations. La recherche d’un meilleur diagnostic de la fibromyalgie est continue.

Et trouver de meilleurs traitements pour les personnes qui ont été atteintes par le trouble de la fibromyalgie est l’une des principales priorités lorsqu’il s’agit de ce trouble unique.

Preuve de lésions nerveuses chez environ la moitié des patients atteints de fibromyalgie

Résumé: Environ la moitié d’un petit groupe de patients atteints de fibromyalgie, un syndrome courant qui provoque des douleurs chroniques et d’autres symptômes, présente des lésions des fibres nerveuses et d’autres signes d’une maladie appelée polyneuropathie à petites fibres (SFPN). ). Contrairement à la fibromyalgie, SFPN a une pathologie claire et est connue pour être causée par des conditions médicales spécifiques, dont certaines peuvent être traitées et parfois guéries.

Environ la moitié d’un petit groupe de patients atteints de fibromyalgie, un syndrome courant qui provoque des douleurs chroniques et d’autres symptômes, a des lésions des fibres nerveuses et d’autres signes d’une maladie appelée polyneuropathie des petites fibres (SFPN). . Contrairement à la fibromyalgie, qui n’a eu aucune cause connue et peu de traitements efficaces, SFPN a une pathologie claire et est connue pour être causée par des conditions médicales spécifiques, dont certaines peuvent être traitées et parfois guéries. L’étude par les chercheurs du Massachusetts General Hospital (MGH) apparaîtra dans la revue DOLOR et a été publiée en ligne.

“Cela fournit une partie de la première preuve objective d’un mécanisme derrière certains cas de fibromyalgie, et l’identification d’une cause sous-jacente est la première étape pour trouver de meilleurs traitements”, explique Anne Louise Oaklander, MD, PhD, directrice de l’unité. dans le département de neurologie de MGH et l’auteur correspondant de l’article de douleur.

Le terme fibromyalgie décrit une série de symptômes, y compris la douleur généralisée chronique, une sensibilité accrue à la pression et à la fatigue, qui affecterait 1 à 5% des personnes dans les pays occidentaux, le plus souvent chez les femmes. Bien que le National Institutes of Health et l’American College of Rheumatology aient reconnu le diagnostic de la fibromyalgie, sa base biologique reste inconnue. La fibromyalgie partage de nombreux symptômes avec le SFPN, une cause reconnue de douleur chronique généralisée pour laquelle des tests objectifs sont acceptés.

Conçu pour étudier les connexions possibles entre les deux conditions, l’étude actuelle a recruté 27 patients adultes atteints de diagnostic de fibromyalgie et 30 volontaires sains. Les participants ont passé une batterie de tests utilisés pour diagnostiquer le SFPN, incluant des évaluations de la neuropathie basée sur un examen physique et des réponses à un questionnaire, des biopsies cutanées pour évaluer le nombre de fibres nerveuses dans les jambes et des tests de fonctions , la pression artérielle et la transpiration.

Les questionnaires, les évaluations d’examen et les biopsies cutanées ont révélé des niveaux significatifs de neuropathie chez les patients atteints de fibromyalgie, mais pas dans le groupe témoin. Sur les 27 patients atteints de fibromyalgie, 13 présentaient une réduction marquée de la densité des fibres nerveuses, des tests de fonction autonome anormaux ou les deux, indiquant la présence de SFPN. Les participants qui répondaient aux critères du SFPN ont également subi des tests sanguins pour des causes connues du trouble, et bien qu’aucun d’entre eux n’ait des résultats évocateurs de diabète, une cause fréquente de SFPN, deux ont été infectés par le virus de l’hépatite. C, qui peut être traité avec succès. et plus de la moitié avaient des preuves d’un dysfonctionnement du système immunitaire.

«Jusqu’à présent, il n’y avait pas une bonne idée de ce qui cause la fibromyalgie, mais maintenant nous avons des preuves pour certains, mais pas pour tous les patients.» La fibromyalgie est trop complexe pour une «taille unique», explique Oaklander, un professeur agrégé de neurologie à la Harvard Medical School. “La prochaine étape de la confirmation indépendante de nos résultats d’autres laboratoires est déjà en cours, et nous devons également suivre les patients qui n’ont pas satisfait aux critères SFPN pour voir si nous pouvons trouver d’autres causes. Aider l’une de ces personnes à recevoir des diagnostics définitifs et un meilleur traitement serait une grande réussite. “

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