Cannabis kan schadelijke effecten hebben op jichtige gewrichten

Patiënten melden dat cannabis artritis in remissie zet, dus financiert de Arthritis Society onderzoek om te bepalen of het waar is.

Er is goed nieuws voor de 54 miljoen mensen met artritis: een onderzoek in opdracht van The Arthritis Society onderzoekt manieren om innovatieve therapieën te ontwikkelen met cannabis voor medische doeleinden.

De Canadese onderzoeker Dr. Jason McDougall ontving van de organisatie een strategische subsidie ​​voor het uitvoeren van een drie jaar durend onderzoek naar het vermogen van cannabis om artritisgewrichten effectief te herstellen. McDougall is hoogleraar Farmacologie en anesthesie aan de Dalhousie University in Halifax, Nova Scotia, en een van ‘s werelds toonaangevende pijnonderzoekers.

Het doel van de studie is om erachter te komen of op cannabis gebaseerde medicijnen meer doen dan de pijn van artritis verlichten – en of het de schade daadwerkelijk kan terugdraaien? Dit is het eerste onderzoek dat door de organisatie wordt gefinancierd om zich rechtstreeks te richten op therapieën die zijn afgeleid van medicinale cannabis.

“Mensen met artritispijn zijn op zoek naar manieren om hun kwaliteit van leven te verbeteren”, zegt Janet Yale, President en CEO van The Arthritis Society. “We hebben onderzoek nodig om de vele belangrijke vragen over medicinale cannabis en het gebruik ervan te beantwoorden. Ons doel is om Canadezen de mogelijkheid te bieden om weloverwogen keuzes te maken over hun behandelopties en om artsen te voorzien van evidence-based richtlijnen voor het aanbevelen van behandelingen aan hun patiënten. Dit project is een belangrijke stap om deze doelen te bereiken. “

Het onderzoek bouwt voort op eerder werk van Chinese wetenschappers die ontdekten dat niet alleen arthritische gewrichten extreem hoge concentraties CB2-receptoren bevatten, maar dat deze plaatsen ook een behandelingsroute suggereren.

Wat is een CB2-ontvanger? In eenvoudige bewoordingen is CB2 een molecuul in de celwand dat dient als toegangspoort tot cannabinoïden. Het is het middel dat de cel gebruikt om de nuttige deeltjes die er doorheen gaan tijdens het dagelijks functioneren van het lichaam te verminderen.

Terwijl het lichaam zijn eigen endocannabinoïden produceert die in staat zijn om via CB2-receptoren een cel te bevestigen en eraan te werken, kunnen medicamenten op basis van cannabis ook door dezelfde poort gaan. Onderzoekers geloven dat dit de effectiviteit van cannabis bij de behandeling van ziekten zoals reumatoïde artritis kan verklaren.

De gedachte is: als het cannabisgeneesmiddel CB2-receptoren kan gebruiken om zich in de cellen te verplaatsen en direct invloed heeft op het triggeren van pijnsignalen in de gewrichten, kan het medicijn dan ook de laesies repareren? gewricht terwijl hij aanwezig is?

Er zijn veel redenen om dat te denken.

Een studie gepubliceerd in het tijdschrift   Philosophical Royal Society B Transactions is   gebleken dat de endocannabinoïde systeem van het lichaam levert antioxidanten die herstellen van beschadigde cellen te helpen wanneer getriggerd door externe cannabinoïden.

En anekdotisch bewijs, zoals het verhaal van een vrouw uit Maine waarvan het gebruik smoothies cannabis was zo opgelucht dat haar symptomen van reumatoïde artritis ging in remissie, zorgen voor extra rechtvaardigingen gedachtestimulans om de mogelijkheden van cannabisbehandeling te verdiepen.

Bovendien gaan bedrijven op pad. Medische cannabisbedrijven van Canada Aphria, Inc. en het Peace Naturals Project beloofde elk 100.000 dollar aan de Arthritis Society om Dr. McDougall’s onderzoeksrekening te betalen. Wanneer de markt optimistisch is over nieuw onderzoek, is het een goed teken voor degenen die lijden.

De realiteit is dat cannabinoïde-receptoren een cruciale rol spelen bij het reguleren van het immuunsysteem van het lichaam. Wat niet duidelijk is, is precies hoe ze werken. Vanuit strikt biologisch oogpunt hebben auto-immuunziekten zoals reumatoïde artritis en chronische ziekten zoals artrose niet veel zin. Waarom zou het lichaam dergelijke cruciale functies als gezamenlijke behendigheid aanvallen of niet kunnen repareren? De ontdekking van cannabinoïde-receptoren op ontstekingslocaties kan een antwoord bieden.

Dankzij een schat aan eerder werk op dit gebied, weet het team van McDougall al dat cannabis medicijnen direct op CB2-plaatsen werken en ontstekingen en pijn onderdrukken door immuunreacties op ontstekingslocaties te veroorzaken. . Dit suggereert dat het lichaam op zoek is naar moleculen om het te helpen zijn vitale elementen te herbouwen.

De volgende stap zal zijn om te bepalen of de veranderingen in het medicijn verschillende reacties in het lichaam veroorzaken. Als onderzoekers nieuwe manieren zouden ontdekken om drugs te accepteren of te gebruiken via cannabinoïde-receptoren, zou dit een venster kunnen openen voor behandelingsopties. Veel van onze huidige kennis bevindt zich in de theoretische sfeer, met de meeste artsen en patiënten eenvoudig dankbaar voor de effectieve behandeling van pijn – of het nu begrepen wordt of niet, het is een secundaire zorg.

Naarmate onze kennis van het endocannabinoïdesysteem van het lichaam toeneemt en we beter kijken naar de manieren waarop op cannabis gebaseerde geneesmiddelen ontstekingen verminderen en de zenuwen beïnvloeden, zullen we waarschijnlijk nieuwe behandelingsmethoden ontdekken. – en mogelijke manieren om gewrichtsschade blijvende artritis te herstellen. Het onderzoek van McDougall is nog niet voltooid, maar de resultaten worden binnenkort verwacht.

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