Cannabis kan ha negative effekter på leddgikt

Pasienter rapporterer at cannabis setter leddgikt i etterligning, slik at arthritissamfundet finansierer forskning for å avgjøre om det er sant.

Det er gode nyheter for de 54 millioner menneskene med leddgikt: En studie utført av The Arthritis Society, undersøker måter å utvikle innovative terapier med cannabis til medisinske formål.

Den canadiske forskeren, Dr. Jason McDougall, mottok et strategisk driftsbidrag fra organisasjonen for å gjennomføre en treårig studie om cannabis evne til effektivt å reparere leddgikt. McDougall er professor i farmakologi og anestesi ved Dalhousie University i Halifax, Nova Scotia, og en av verdens ledende smerteforskere.

Studien tar sikte på å finne ut om cannabisbaserte medisiner gjør mer enn å lindre smerten ved leddgikt – og hvis det faktisk kan reversere skadene? Dette er den første forskningen finansiert av organisasjonen for å fokusere direkte på terapier fra medisinsk cannabis.

“Folk med leddgikt smerte leter etter måter å forbedre deres livskvalitet, sier Janet Yale, president og administrerende direktør i Arthritis Society. “Vi trenger forskning for å svare på de mange viktige spørsmålene om medisinsk cannabis og bruken av den. Vårt mål er å gi kanadiere muligheten til å ta informerte valg om deres behandlingsmuligheter og å gi leger med bevisbaserte retningslinjer for å anbefale behandlinger til pasientene. Dette prosjektet er et viktig skritt mot å nå disse målene. “

Forskningen bygger på tidligere arbeid av kinesiske forskere som oppdaget at ikke bare arthritiske ledd inneholder ekstremt høye konsentrasjoner av CB2-reseptorer, men at disse områdene også foreslår en behandlingsrute.

Hva er en CB2-mottaker? Enkelt sagt er CB2 et molekyl i celleveggen som fungerer som en inngangsport til cannabinoider. Det er midlene som brukes av cellen for å redusere de nyttige partiklene som passerer gjennom det under kroppens daglige funksjon.

Mens kroppen produserer sine egne endokannabinoider som er i stand til å feste og arbeide på en celle gjennom CB2-reseptorer, kan cannabisbaserte legemidler også passere gjennom samme port. Forskere mener dette kan forklare effektiviteten av cannabis ved behandling av sykdommer som reumatoid artritt.

Tanken er: Hvis cannabis-stoffet kan bruke CB2-reseptorer til å bevege seg inne i cellene og direkte påvirke utløsningen av smertesignaler i leddene, kan stoffet også reparere lesjonene? ledd mens han er til stede?

Det er mange grunner til å tenke på det.

En studie publisert i tidsskriftet   Philosophical Transactions of the Royal Society B  avslørte at kroppens endokannabinoide system frigjør antioksidanter som hjelper til med å reparere skadede celler når de utløses av eksterne cannabinoider.

Og anekdotiske bevis, for eksempel historien om en Maine-kvinne hvis bruk av cannabis smoothies har vært så lettet at hennes reumatoid artritt symptomer har gått til ettergivelse, gi andre tankevekkende begrunnelser. å utdype mulighetene for cannabisbehandling.

I tillegg kommer bedrifter på bandwagon. Medisinsk Cannabis Selskaper i Canada Aphria, Inc. og Peace Naturals Project hver lovet $ 100.000 til leddgiktforeningen for å betale Dr. McDougalls forskningsregning. Når markedet er optimistisk om ny forskning, er det et godt tegn på de som lider.

Virkeligheten er at cannabinoidreseptorer spiller en avgjørende rolle for å regulere kroppens immunsystem. Det som ikke er klart, er akkurat hvordan de fungerer. Fra et strengt biologisk synspunkt, gir ikke autoimmune sykdommer som reumatoid artritt og kroniske sykdommer som slitasjegikt svært mening. Hvorfor ville kroppen angripe eller ikke kunne reparere slike avgjørende funksjoner som felles fingerferdighet? Oppdagelsen av cannabinoidreseptorer på inflammatoriske steder kan gi et svar.

Takket være et vell av tidligere arbeid i dette området, vet McDougalls team allerede at cannabismedisiner jobber direkte på CB2-steder og undertrykker betennelse og smerte ved å formidle immunrespons på steder med betennelse. . Dette antyder at kroppen ser etter molekyler for å hjelpe den å gjenoppbygge sine vitale elementer.

Det neste trinnet vil være å avgjøre om endringene i stoffet forårsaker forskjellige reaksjoner i kroppen. Hvis forskere kunne oppdage nye måter å godta eller bruke rusmidler gjennom cannabinoidreseptorer, kan dette åpne et vindu for behandlingsmuligheter. Mye av vår nåværende kunnskap er i teoretisk sfære, med de fleste leger og pasienter rett og slett takknemlig for effektiv behandling av smerte – enten det er forstått eller ikke, er det en sekundær bekymring.

Men siden vår kunnskap om kroppens endokannabinoide system vokser og vi ser nærmere på hvordan cannabisbaserte stoffer reduserer betennelse og påvirker nerver, vil vi sannsynligvis oppdage nye behandlingsmetoder. – og mulige måter å reversere leddskader vedvarende leddgikt. McDougalls forskning er ikke fullført, men resultater forventes snart.

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