Cannabis kan ha negativa effekter på artritiska leder

Patienter rapporterar att cannabis sätter artrit i eftergift, så Arthritis Society finansierar forskning för att avgöra om det är sant.

Det finns goda nyheter för de 54 miljoner personer med artrit: en studie som bedrivs av artritföreningen utforskar sätt att utveckla innovativa terapier med cannabis för medicinska ändamål.

Den kanadensiska forskaren Dr. Jason McDougall fick en strategisk verksamhetsbidrag organisationen att genomföra en treårig studie på förmågan hos cannabis att effektivt reparera artros lederna. McDougall är professor i farmakologi och anestesi vid Dalhousie University i Halifax, Nova Scotia, och en ledande smärtforskare över hela världen.

Studien syftar till att ta reda på om cannabis-baserade mediciner göra mer än att lindra smärta som orsakas av artrit – och om det faktiskt kan vända skadan? Detta är den första finansierad forskning organisation att fokusera direkt härrör terapier medicinsk cannabis.

“Människor med artrit-smärta letar efter sätt att förbättra livskvaliteten”, säger Janet Yale, VD och koncernchef för Arthritis Society. “Vi behöver forskning som hjälper till att svara på de många viktiga frågorna om medicinsk cannabis och dess användning. Vårt mål är att ge kanadensare möjlighet att fatta välgrundade val om sina behandlingsalternativ och att ge läkare bevisbaserade riktlinjer för att rekommendera behandlingar till sina patienter. Detta projekt är ett viktigt steg mot att uppnå dessa mål. “

Forskningen bygger på tidigare arbete av kinesiska forskare som upptäckte att inte bara artritiska leder innehåller extremt höga koncentrationer av CB2-receptorer, men att dessa platser också föreslår en behandlingsväg.

Vad är en CB2-mottagare? Enkelt uttryckt är CB2 en molekyl i cellväggen som fungerar som en gateway till cannabinoider. Det är de medel som används av cellen för att minska de användbara partiklarna som passerar genom det under kroppens dagliga funktion.

Medan kroppen producerar egna endokannabinoider som kan fästa och arbeta på en cell genom CB2-receptorer kan cannabisbaserade droger också passera genom samma grind. Forskare tror att detta kan förklara effekten av cannabis vid behandling av sjukdomar som reumatoid artrit.

Tanken är: om cannabisläkemedlet kan använda CB2-receptorer för att röra sig inuti cellerna och direkt påverka utlösningen av smärtsignaler i lederna, kan läkemedlet också reparera lesionerna? articular medan han är närvarande?

Det finns många anledningar att tänka på.

En studie publicerad i tidskriften   Philosophical Transactions of Royal Society B  avslöjade att kroppens endokannabinoid-system släpper ut antioxidanter som hjälper till att reparera skadade celler när de utlöses av externa cannabinoider.

Och anekdotiska bevis, som berättelsen om en Maine kvinna vars användning av cannabis smoothies har varit så lättad att hennes reumatoid artrit symptom har gått till eftergift, ger andra tankeväckande motiveringar. att fördjupa möjligheterna till cannabisbehandling.

Dessutom kommer företag på bandwagon. Medicinska cannabisföretag i Kanada Aphria, Inc. och fred naturalsprojektet lovade varje 100.000 dollar till artritföreningen att betala Dr McDougalls forskningsräkning. När marknaden är optimistisk för ny forskning är det ett gott tecken på dem som lider.

Verkligheten är att cannabinoidreceptorer spelar en avgörande roll för att reglera kroppens immunförsvar. Det som inte är klart är exakt hur de fungerar. Ur en strikt biologisk synpunkt är autoimmuna sjukdomar som reumatoid artrit och kroniska sjukdomar som artros inte mycket förnuftiga. Varför skulle kroppen attackera eller inte kunna reparera sådana avgörande funktioner som gemensam fingerfärdighet? Upptäckten av cannabinoidreceptorer på inflammatoriska ställen kan ge ett svar.

Tack vare en mängd tidigare arbete inom detta område vet McDougalls team redan att cannabismedicin fungerar direkt på CB2-platser och undertrycker inflammation och smärta genom att mediera immunsvar vid inflammationsställen. . Detta tyder på att kroppen letar efter molekyler för att hjälpa till med att bygga upp dess vitala element.

Nästa steg kommer att vara att bestämma om förändringarna av drogen orsakar olika reaktioner i kroppen. Om forskare skulle kunna upptäcka nya sätt att acceptera eller använda droger via cannabinoidreceptorer, kan detta öppna ett fönster för behandlingsalternativ. Mycket av vår nuvarande kunskap ligger i den teoretiska sfären, med de flesta läkare och patienter som är tacksamma för effektiv behandling av smärta – oavsett om det förstås eller inte är det ett sekundärt problem.

Men eftersom vår kunskap om kroppens endokannabinoidsystem växer och vi tittar närmare på hur cannabisbaserade droger minskar inflammation och påverkar nerverna, kommer vi sannolikt att upptäcka nya behandlingsmetoder. McDougalls forskning är ännu inte färdig, men resultaten väntas inom kort.

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