Wie kann Amitriptylin Menschen mit Fibromyalgie helfen?

Im Laufe der Jahre wurden verschiedene Medikamente zur Verwendung bei der Behandlung von Fibromyalgie bewertet. Diese Medikamente umfassen Muskelrelaxanzien, Kortikosteroide, nichtsteroidale Antirheumatika (NSAIDs), Sedativa und trizyklische Antidepressiva.

Trizyklische Antidepressiva haben tatsächlich einen Hintergrund in der Behandlung von Fibromyalgie. Tatsächlich werden mehrere dieser Antidepressiva bei der Behandlung der Krankheit verwendet. Nortriptylin, Doxepin und Amitriptylin werden zur Behandlung von Fibromyalgie verwendet. Insbesondere bei Fibromyalgie wurde in Studien gezeigt, dass es das wirksamste Antidepressivum zur Behandlung der Krankheit ist.

Über Amitriptylin bei Fibromyalgie

Amitriptylin ist, wie erwähnt, eine Art trizyklisches Antidepressivum (TCA), das zur Behandlung von Depressionen eingesetzt wird. Daher gilt es als das weltweit am häufigsten verwendete TCA.

Das Antidepressivum wurde ursprünglich von Merck entwickelt und 1960 erstmals synthetisiert. Im April 1961 wurde es von der Food and Drug Administration genehmigt.

Dieses Medikament wirkt als Inhibitor der Gehirnchemikalien Serotonin und Noradrenalin. Der Wirkmechanismus des Medikaments wirkt stark auf den Serotonin-Transporter, während es eine moderate Wirkung auf den Noradrenalin-Transporter ausübt. Es wirkt sich jedoch nicht auf den Dopamin-Transporter aus.

Amitriptylin wird bei verschiedenen Erkrankungen angewendet, einschließlich der von der FDA zugelassenen Anwendung bei Depressionen. Das hindert andere medizinische Ressourcen nicht daran, zu sagen, dass es eine Rolle spielt, wenn es darum geht, andere ähnliche Zustände zu heilen.

Es wird sogar gesagt, dass Amitriptylin bei der Behandlung von Störungen wirksamer ist als andere Antidepressiva. Interessanterweise werden andere neuere Antidepressiva tatsächlich übersehen, da bekannt ist, dass sie Nebenwirkungen verursachen und bei Überdosierung sehr giftig werden können.

Antidepressiva und Fibromyalgie.

Zur Behandlung der Symptome der Fibromyalgie werden verschiedene Medikamente eingesetzt. Zu den häufigsten Medikamenten gehören Schmerzmittel, Schlaftabletten und verschiedene Antidepressiva. Es wird gesagt, dass Antidepressiva helfen, die Symptome der Fibromyalgie zu behandeln, die   durch Funktionsstörungen der regulären Funktionen des Gehirns verursacht werden  .

Antidepressiva, insbesondere trizyklische Antidepressiva, werden seit Jahren zur Behandlung von Fibromyalgie eingesetzt. Trizyklische Antidepressiva gehören zu den ältesten Antidepressiva auf dem Markt und werden seit Jahren bei Fibromyalgie-Behandlungen eingesetzt.

Trizyklische Antidepressiva wie Amitriptylin wirken, indem sie die Konzentration von Gehirnchemikalien oder Neurotransmittern erhöhen. Wenn die Anzahl der Neurotransmitter erhöht wird, verhindert dies, dass das Gehirn seiner natürlichen Funktion nachgibt. Diese Antidepressiva erhöhen hauptsächlich die Neurochemikalien Serotonin und Noradrenalin. Nach der Einnahme dieser Antidepressiva fühlen sich Menschen mit chronischen Schmerzen in der Regel viel besser, da bekannt ist, dass die im Gehirn genannten Neurotransmitter niedriger sind.

Trizyklische Antidepressiva helfen auch bei Muskelkater. Es erhöht auch das natürliche Schmerzmittel des Körpers, auch Endorphine genannt. Obwohl diese Medikamente bei Krankheiten wie Fibromyalgie positive Auswirkungen haben, haben sie verschiedene Nebenwirkungen, die eine regelmäßige Einnahme erschweren können.

Interessanterweise gehören zu den tricyclischen Antidepressiva, die für Fibromyalgie verschrieben werden, Duloxetin, Milnacipran und Venlafaxin. Sowohl Duloxetin als auch Milnacipran sind bereits von der Food and Drug Administration zur Behandlung von Fibromyalgie zugelassen.

Venlafaxin hat weniger Forschung und ist daher der Beweis dafür, dass es eine wirksame Behandlung unterstützt. Andere Antidepressiva, die als mögliche Behandlungen für Fibromyalgie untersucht und vorgeschlagen wurden, umfassen Citalopram, Paroxetin und Fluoxetin.

Amitriptylin fällt in die Kategorie relativer unbewiesener trizyklischer Antidepressiva ohne weitere Unterstützung als Behandlung von Fibromyalgie. Es hat die Forscher jedoch nicht daran gehindert, es und sein Potenzial als wirksame Behandlung von Fibromyalgie zu untersuchen.

Studien zu Amitriptylin.

Antidepressiva werden seit Jahren zur Behandlung chronischer Schmerzstörungen eingesetzt. Obwohl dies wahr ist, gibt es nur eine begrenzte Anzahl von Studien, in denen beschrieben wird, wie trizyklische Antidepressiva den Menschen helfen, ihre Symptome der Fibromyalgie zu behandeln.

Gemäß den gesammelten Informationen zu Fibromyalgie und Antidepressiva führten Antidepressiva, wie trizyklische Antidepressiva, zu leichten bis mäßigen Verbesserungen der Symptome von [Fibromyalgie]. In kontrollierten Studien wurde festgestellt, dass ein Drittel bis die Hälfte der überwachten Patienten auf eine medikamentöse Behandlung ansprechen.

In einer Studie wurden die Auswirkungen von Amitriptylin und Fluoxetin bei Patienten mit Fibromyalgie getestet. Die Patienten in dieser Studie erhielten 25 mg Amitriptylin, während andere 20 mg Fluoxetin erhielten.

Infolgedessen stellten die Patienten fest, dass alle Medikamente dazu beitrugen, die Symptome der Fibromyalgie zu reduzieren. Patienten, die beide Medikamente eingenommen hatten, stellten fest, dass die Kombination tatsächlich “doppelt so wirksam” war wie die alleinige Einnahme von Medikamenten.

Die für Amitriptylin bei Fibromyalgie verwendeten Dosen sind viel niedriger als die üblichen Dosen zur Behandlung von Depressionen. In den meisten Fällen kann die Dosis mit einer Dosis von nur 10 mg pro Tag begonnen werden und wird 2 bis 3 Stunden vor dem Schlafengehen eingenommen. Dadurch kann der Patient die beruhigenden Wirkungen des Medikaments ausnutzen, ohne beim Aufwachen die gleichen Wirkungen zu erfahren.

In einer weiteren Studie von Amitriptylin wurden 70 verschiedene Patienten mit der Erkrankung Fibromyalgie untersucht. Der Hauptzweck der Studie untersuchte die Wirksamkeit einer regelmäßigen Dosis von 50 mg bei Fibromyalgie.

Die Ergebnisse der Studie haben einige interessante Daten ergeben. Patienten, die die reguläre Dosis von 50 mg gegen Fibromyalgie erhielten, sahen eine “signifikante Verbesserung der Schlafqualität, der Morgensteifigkeit und der Schmerzschwellen”. Die zu diesem Zeitpunkt ermittelten “Punkte der Ausschreibungspunkte” verbesserten sich nicht.

Die neuesten Studien zu diesem Medikament für Fibromyalgie-Patienten folgen der neuesten Version der Fibromyalgie-Kriterien. Eine Komplikation der Daten aus anderen Studien zu Medikamenten ergab, dass “Amitriptylin bei Fibromyalgie weiterhin zur Behandlung [von neuropathischen Schmerzen] verwendet werden kann, die meisten Patienten jedoch keine ausreichende Schmerzlinderung erzielen.”

Mehrere im Rahmen der Komplikation gesammelte Studien dauerten im Durchschnitt bis zu 6 Wochen. Sie führten auch Tests zwischen 15 und 100 Teilnehmern durch, und vier der Studien erhielten mehr als 100 Teilnehmer. In jeder Studie wurden Dosen zwischen 15 mg und 125 mg verabreicht.

In einigen Studien wurde die Dosis während der ausgewählten Intervalle der Teststudie schrittweise erhöht. Im Allgemeinen wurden keine konkreten Beweise gefunden, die Amitriptylin als wirksame Behandlung von Fibromyalgie unterstützen. Einige Studien haben gezeigt, dass es eine Rolle bei der Verringerung neuropathischer Schmerzen spielen kann, beispielsweise bei Schmerzen, die mit Fibromyalgie einhergehen.

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