Le nouveau test sanguin pour la fibromyalgie est précis à 99%. Tout le monde a besoin de savoir ‘Traitement avancé des moisissures’

Un nouveau test sanguin pour la fibromyalgie est plus précis que prévu et ne confondra pas le trouble de la douleur chronique avec d’autres maladies telles que le lupus et la polyarthrite rhumatoïde, selon le médecin qui a développé le test. 
“Nous n’avons trouvé aucun chevauchement entre les biomarqueurs de la fibromyalgie et les profils du système immunitaire des patients atteints de polyarthrite rhumatoïde ou de lupus. Cela a pour effet d’exhaler l’esprit des opposants”, a déclaré Bruce Gillis, MD, fondateur et PDG d’EpicGenetics, un Société de recherche en bio-recherche basée à Santa Monica, Californie.

Un nouveau test sanguin pour la fibromyalgie est plus précis que prévu et ne confondra pas le trouble de la douleur chronique avec d’autres maladies telles que le lupus et la polyarthrite rhumatoïde, selon le médecin qui a développé le test.

“Nous n’avons trouvé aucun chevauchement entre les biomarqueurs de la fibromyalgie et les profils du système immunitaire des patients atteints de polyarthrite rhumatoïde ou de lupus. Cela a pour effet d’exhaler l’esprit des opposants “, a déclaré Bruce Gillis, MD, fondateur et PDG d’Epic Genetics, une société de recherche en bio-recherche basée à Santa Monica, en Californie.

EpicGenetics a présenté le test FM en mars et l’a qualifié de premier test sanguin définitif pour la fibromyalgie, un trouble mal compris caractérisé par une douleur profonde des tissus, de la fatigue, des maux de tête, une dépression et un manque de sommeil. . Les résultats des tests sont généralement disponibles dans une semaine environ.

Le test FM recherche des molécules de protéines dans le sang, appelées chimiokines et cytokines, qui sont produites par les globules blancs. Selon Gillis, les patients atteints de fibromyalgie ont moins de chimiokines et de cytokines dans le sang et, par conséquent, leur système immunitaire est plus faible que les patients normaux.

Les critiques ont déclaré que les mêmes biomarqueurs du système immunitaire peuvent être trouvés chez les personnes atteintes d’autres maladies, telles que la polyarthrite rhumatoïde, ce qui rend le test sanguin peu fiable.

Cependant, dans une nouvelle étude portant sur plus de 300 patients atteints de fibromyalgie, de lupus ou de polyarthrite rhumatoïde, Gillis a déclaré que seuls les patients atteints de fibromyalgie présentaient des taux de chimiokines et de cytokines inférieurs à la normale.

“Ils n’ont pas les mêmes biomarqueurs du système immunitaire. Pas du tout “, a déclaré Gillis au National Pain Report. “Les modèles que nous voyons dans le lupus et la polyarthrite rhumatoïde, nous voyons ce processus inflammatoire. Mais nous ne voyons pas les mêmes biomarqueurs dans la fibromyalgie. “

Gillis a déclaré que la recherche est en cours de finalisation et espère qu’elle sera publiée dans un journal médical revu par des experts dans les mois à venir.

EpicGenetics a déclaré que le diagnostic de fibromyalgie était précis à 93% lors de l’introduction du test FM. Gillis dit que la sensibilité du test est maintenant estimée à 99%, soit à peu près la même chose que le test utilisé pour diagnostiquer le VIH.

Dr. Bruce Gillis

Les National Institutes of Health estiment que 5 millions d’Américains souffrent de fibromyalgie et des millions d’autres dans le monde, mais à ce jour, seuls quelques centaines se sont inscrits au test FM. Gillis dit que le coût de 744 $, qui n’est généralement pas couvert par l’assurance maladie, pourrait constituer un obstacle pour de nombreux patients.

“Beaucoup de personnes chez qui on a diagnostiqué une fibromyalgie ne travaillent pas. Et parce qu’ils ne travaillent pas, ils ne peuvent pas se permettre un test. Ils n’ont pas d’assurance maladie “, a déclaré Gillis, ajoutant que certains assureurs avaient fourni des preuves dans les affaires d’indemnisation des travailleurs. 
“Lorsque nous avons commencé, l’analyse des paramètres du système immunitaire d’un patient nous a coûté 12 500 $. Nous baissons donc les prix, très bas. “

Gillis espère faire baisser le prix du test FM en permettant à d’autres laboratoires de prélever du sang et d’envoyer des échantillons de sang à EpicGenetics.

Peu importe le coût, les patients atteints de fibromyalgie sont enthousiastes à l’idée de la possibilité d’un test simple permettant de diagnostiquer un trouble pour lequel leur médecin et leurs proches sont souvent sceptiques. Il faut trois à cinq ans pour diagnostiquer chez le patient une fibromyalgie moyenne.

“Avoir un marqueur sanguin fiable fera plus que nous valider en tant que patients. Cela ouvrira un champ de rêves et de possibilités aux chercheurs compatissants pour définir cet horrible trouble “, a déclaré Celeste Cooper, une patiente atteinte de fibromyalgie et son défenseur.

“Une fois que nous aurons un test biologique, nous saurons que les participants à l’étude sont atteints de fibromyalgie. Il n’y aura pas de résultats biaisés, et la discussion sur la maladie psychologique sera dans notre miroir d’examen. C’est une pensée savoureuse. “

Ces derniers mois, plusieurs avancées potentielles ont été réalisées dans la recherche sur la fibromyalgie.

Les chercheurs de l’État de l’Ohio en sont aux premières étapes de la mise au point d’un autre type de test sanguin pour la fibromyalgie. À l’aide d’un microscope infrarouge à haute puissance, ils ont identifié un modèle de molécules dans le sang qui semble être unique pour les patients atteints de fibromyalgie.

Une autre équipe de chercheurs de l’état de New York a découvert que la fibromyalgie avait un excès de fibres nerveuses sensorielles dans les vaisseaux sanguins des mains, ce qui pouvait interrompre la circulation du sang dans le corps.

“En moins de six mois, deux études rapportent une analyse réussie de la fibromyalgie à l’aide de marqueurs sanguins. Il semble maintenant qu’elle entre dans une zone dépassant plusieurs débats “, a déclaré Cooper.

“C’est une victoire pour la communauté scientifique et pour le patient. Je doute que ce soit la dernière. Attendez-vous à plus de recherches à mesure que la course progresse et à quel point ce sera glorieux pour ceux d’entre nous qui vivent avec la fibromyalgie tous les jours. “

La recherche pourrait également mener à la découverte d’un marqueur génétique de la fibromyalgie, un gène qui rend certaines personnes plus susceptibles de développer la maladie.

EpicGenetics sauve de nombreux échantillons de sang prélevés sur des patients ayant passé le test FM, dans l’espoir de les analyser un jour pour détecter l’acide ribonucléique (ARN), des molécules impliquées dans la synthèse des protéines et la transmission des informations génétiques.

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