NEURONTIN e LYRICA são uma sentença de morte para novas sinapses cerebrais: estudo chocante

Um estudo chocante mostra que esses dois fármacos bloqueiam a formação de novas sinapses cerebrais1, reduzindo drasticamente o potencial de rejuvenescimento da plasticidade cerebral – o que significa que essas drogas irão provocar um declínio cerebral que, aparentemente, roube uma das habilidades para reconstruir. O estudo que demonstrou esse tipo de dano cerebral com essas duas drogas surgiu em 2009, mas aparentemente a mídia tem sido muito negligente em obter qualquer uma dessas informações para o público – provavelmente porque elas não querem pôr em perigo suas receitas de publicidade dessa empresa.

Imagem relacionada
Mas os pacientes não são os únicos que não obtêm esta informação, porque os médicos também não têm ideais. Eu digo isso porque primeiro nosso grupo do Facebook para esses dois medicamentos “Neurontin (Gabapentin) e Lyrica (Pregabalin) deve ser ilegal” está crescendo tão rapidamente. Então, no passado Spring, meu irmão trabalhando em algumas coisas no quintal puxou um músculo nas costas. Fiquei chocado ao saber que ele tinha ido ao médico por isso e o médico lhe deu uma receita para Neurontin!
Quando perguntei quando ele começou a ter convulsões que ele precisaria de um medicamento anti-convulsão, ele disse: “O quê ?!”
Eu tinha que explicar para ele que a Neurontin é uma medicação anti-convulsão e que a empresa recebeu duas grandes multas, totalizando bilhões, da FDA por prescrevê-lo para qualquer outra coisa. E, em 2010, foram até mesmo culpados de RICO, sim escavações, para incentivar os médicos a prescrever este medicamento fora do rótulo – por coisas para as quais não é aprovado – como puxar um músculo nas suas costas! Então eu compartilhei com ele as informações neste estudo indicando o dano cerebral da droga em que ponto ele compreensivelmente decidiu não tomar a droga.
Embora tenha incluído o artigo completo sobre este abaixo, este é o link para o artigo que você precisa seguir para encontrar o estudo de pesquisa completo, se você quer levar isso ao seu médico para educá-lo: https://www.wellnessresources.com / news / neurontin-and-lyrica-are-a-death-sentence-for-new-brain-synapses # ref1

Agora, minha pergunta é por que a FDA não tirou essas drogas do mercado à luz desse estudo? Eu pergunto porque, antes deste estudo, o pior que eu tinha visto na produção de dano cerebral eram as pílulas dietéticas Fen-Phen e Redux que foram retiradas do mercado devido ao dano cerebral que produziram … mesmo que a mídia convencesse o mundo de que essas drogas foram puxadas devido ao dano no coração e nos pulmões. Foi o dano cerebral que o FDA estava preocupado e exigiu estudos do fabricante para provar sua segurança. Algo que eles ainda não tinham feito antes de a Dra. Una Mc Cann no NIH colocar um estudo mostrando o dano cerebral mais horrível. Essas drogas foram puxadas apenas alguns dias depois.

Neurontin e Lyrica são uma frase de morte para novas sinapses cerebrais

Neurontin e sua versão mais nova e mais potente, Lyrica, são amplamente utilizadas para indicações fora do rótulo que são um perigo flagrante para o público. Esses medicamentos de blockbuster foram aprovados para uso, embora o FDA não tivesse idéia do que eles realmente fizeram no cérebro. Um novo estudo chocante mostra que eles bloqueiam a formação de novas sinapses cerebrais1, reduzindo drasticamente o potencial de rejuvenescimento da plasticidade cerebral – o que significa que estas drogas irão causar declínio cerebral mais rápido do que qualquer substância conhecida pela humanidade.

 

O problema dessas drogas é agravado pelo seu flagrante marketing ilegal. Neurontin foi aprovado pela FDA para epilepsia em 1994. A droga sofreu uma promoção ilegal maciça fora do rótulo que custou à Warner-Lambert 430 milhões de dólares (a primeira grande multa para a promoção fora do rótulo). A droga agora é propriedade da Pfizer. A Pfizer também possui Lyrica, uma versão super potente da Neurontin. Foi aprovado pela FDA para vários tipos de dor e fibromialgia. Lyrica é uma das quatro drogas que uma subsidiária da Pfizer comercializou ilegalmente, resultando em uma liquidação de US $ 2,3 bilhões contra a Pfizer.

Even though the marketing of these drugs has been heavily fined, they continue to rack up billions in sales from the off-label uses. Doctors use them for all manner of nerve issues because they are good at suppressing symptoms. However, such uses can no longer be justified because the actual mechanism of the drugs is finally understood and they are creating a significant long-term reduction in nerve health.

Os pesquisadores do estudo acima tentam minimizar a natureza séria das drogas dizendo que “os neurônios adultos não formam muitas novas sinapses”. Isso simplesmente não é verdade. A nova ciência está mostrando que a saúde cerebral durante o envelhecimento depende da formação de novas sinapses. Mesmo esses pesquisadores conseguiram questionar o uso comum desses medicamentos em mulheres grávidas. Como é que um feto deve fazer novas células nervosas quando a mãe está tomando uma droga que as bloqueia?

Estes são o tipo de situações em que o FDA deve estar completo. Como de costume, o FDA está sentado em torno de ponderar um aviso de suicídio para Lyrica, enquanto os seus usos fora do rótulo incluem transtorno bi-polar e dores de cabeça de enxaqueca. A FDA provavelmente abrirá os polegares para a próxima década sobre o problema do dano cerebral. Consumidor tome cuidado.

Estudos referenciados
^ Neurontin e Lyrica são altamente tóxicos para novas células sincíveis do cérebro Çagla Eroglu, Nicola J. Allen, Michael W. Susman, Nancy A. O’Rourke, Chan Young Park, Engin Özkan, Chandrani Chakraborty, Sara B. Mulinyawe, Douglas S. Annis, Andrew D. Huberman, Eric M. Green, Jack Lawler, Ricardo Dolmetsch, K. Christopher Garcia, Stephen.

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