Le vaccin donne un nouvel espoir communauté Centennial de la fibromyalgie

Par Donna Gregory Burch Si quelqu’un pourrait donner un vaccin qui guérirait la fibromyalgie, diriez-vous? Cela peut sembler comme un rêve, mais est plus proche de la réalité que vous pourriez penser. EpicGenetics firme biomédicale et des chercheurs du Massachusetts General Hospital cherchent l’approbation de la Food and Drug Administration des États-Unis (FDA) pour mener un essai clinique l’année prochaine pour tester le vaccin Bacille Calmette-Guérin (BCG ) en tant que traitement potentiel pour la fibromyalgie.
« Le BCG est un vaccin contre la tuberculose générique qui a près de 100 ans et a été administré en toute sécurité des millions de fois », a déclaré le Dr Denise Faustman, directeur du Laboratoire Faustman du Massachusetts General Hospital. « Depuis plus de 10 ans, notre groupe de recherche au Massachusetts General Hospital a étudié activement le rôle que la vaccination BCG pourrait jouer dans le traitement de diverses formes de l’auto-immunité. Notre objectif actuel est diabète de type 1, mais le BCG ensemble est mis à l’essai dans un certain nombre de maladies auto-immunes. Au cours des deux prochaines années, nous allons commencer les essais cliniques de BCG dans la fibromyalgie ».
Selon de l’Organisation mondiale de la Santé, plus de 100 millions d’ enfants reçoivent le vaccin BCG chaque année. Il est utilisé principalement dans les pays en développement où la tuberculose est toujours active. Le vaccin BCG n’est pas disponible aux États-Unis en raison de la faible risque d’infection. Aux États-Unis, le BCG est utilisé dans un petit nombre de patients pour traiter le cancer de la vessie.
Donc, la question est évidente : pourquoi un vaccin pour une maladie pulmonaire infectieuse est utilisé pour la fibromyalgie? La réponse est dans le système immunitaire.
Les vaccins sont généralement donnés à des personnes en bonne santé pour prévenir l’ infection. Dans ce cas, toutefois, le vaccin BCG aux patients atteints de fibromyalgie administré dans un effort pour apaiser vos symptômes.
Lorsque EpicGenetics a été chargé de créer un test de diagnostic de la fibromyalgie pour plusieurs années, des chercheurs ont mené toutes sortes de tests de laboratoire chez les patients atteints de fibromyalgie pour savoir comment ils diffèrent des sujets témoins en bonne santé et ce qui pourrait être la cause de vos symptômes. Les chercheurs ont constaté plusieurs anomalies de globules blancs chez les patients atteints de fibromyalgie, ce qui conduit les conclure que les symptômes sont associés à un système immunitaire affaibli.
« Nous pensons que [le terme] La fibromyalgie est un abus de langage , » a déclaré le Dr Bruce Gillis, directeur général de EpicGenetics. « Ces gens ne souffrent pas avec tout ce qui affecte les muscles, pour dire. Qu’est – ce que souffrent est que votre système immunitaire ne peut pas produire des quantités normales de protéines protectrices. … Il y a des cellules du système immunitaire appelées cellules mononucléées du sang du sang périphérique. Ils ne produisent pas des quantités normales de protéines protectrices appelées chimiokines et cytokines ».
La découverte a conduit à l’ élaboration de l’ analyse FM / a pour la fibromyalgie. Le test semble au niveau de quatre chimiokines et cytokines trouvés à des niveaux réduits chez les patients atteints de fibromyalgie. Ces quatre chimiokines et cytokines sont les mêmes que sont alimentés par vaccination par le BCG.
« Compte tenu de ce qui a été publié dans la littérature médicale, nous croyons que ce vaccin va inverser les anomalies du système immunitaire [fibromyalgie] , » a dit Gillis.
Gillis et Faustman cherchent l’ approbation de la FDA pour administrer les premiers vaccins BCG patients avec la fibromyalgie début de l’ année prochaine.
« Ceci est la première fois un traitement direct de la fibromyalgie est fait , » a dit Gillis. « Comme vous le savez, les médicaments [sur le marché] pour la fibromyalgie ne traitent que les symptômes. Ils ont aucun avantage du système immunitaire. [Sociétés pharmaceutiques] reconnaissent qu’ils ne sont traiter les symptômes, mais vous avez besoin de traiter la maladie, et qui est la raison pour laquelle nous allons de l’ avant avec la mise en œuvre du vaccin »[FDA].
Gillis Si la théorie est vraie, alors « chimiokines et cytokines qui sont déficients chez les patients atteints de fibromyalgie ne plus être déficient [une fois que le vaccin BCG est administré] , » a dit Gillis. « Les niveaux de production normaliseront, et nous devons supposer que leurs symptômes disparaissent. … Nous croyons que nous sommes sur le point de quelque chose d’ important. «
Parce que le vaccin a une longue histoire, il est ne devrait pas entraîner des effets secondaires importants chez les patients.
On prévoit que les coûts de vaccination par le BCG entre 20 et 25 dollars par dose, un montant nominal par rapport à la charge continue de prendre des médicaments tous les jours.
« Nous croyons qu’un patient de la fibromyalgie aurait besoin d’ une ou deux doses maximales afin que vous puissiez comprendre pourquoi je ne reçois pas beaucoup de soutien des compagnies pharmaceutiques , » a dit Gillis.
En plus de tester des vaccins, EpicGenetics est en partenariat avec l’Université de Californie, Los Angeles (UCLA) et l’Université de l’ Illinois College of Medicine de Chicago pour séquencer les génomes de 250.000 patients atteints de fibromyalgie.


« Nous sommes à la recherche pour des modèles ou des anomalies ou des mutations génétiques , » a dit Gillis.
Les patients dont le test est positif pour la fibromyalgie par FM / un test génomique peuvent participer étude inThe. FM / test coûte actuellement 936 $, mais il est couvert par certaines compagnies d’assurance et l’ assurance – maladie. L’équipe de soutien EpicGenetics aide les patients à déterminer si votre compagnie d’assurance va couvrir l’épreuve. Un intérêt – plan de paiement est disponible gratuitement pour les personnes qui ne sont pas assurés ou dont l’ assurance ne ne couvre pas le test.

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