Carence en endocanabinoïdes conduit à la fibromyalgie. Enquête nationale sur la douleur

En 2014, un sondage de plus de 1300 patients atteints de fibromyalgie par National Pain Foundation et National Pain Report a révélé que la marijuana médicale est plus efficace que Lyrica, Cymbalta ou Savella, les trois médicaments approuvés par la Food and Drug Administration pour traiter le trouble. (Si vous êtes curieux au sujet de l’efficacité de Lyrica, Cymbalta et Savella, alors vous pourriez être intéressé par mon article, “Pourquoi vos médicaments fibro ne fonctionnent pas.”)

Il y a de plus en plus de preuves anecdotiques que la marijuana soulage la douleur de la fibromyalgie, mais les recherches actuelles sont encore rares. Le cannabis reste une substance contrôlée de l’annexe I aux États-Unis, ce qui fait qu’il est difficile pour les chercheurs d’étudier les propriétés analgésiques de la plante. À ce jour, il y a eu moins d’une poignée de petites études utilisant le cannabis ou ses dérivés pour traiter la fibromyalgie. La plupart d’entre eux ont montré qu’il était bénéfique, en particulier pour soulager la douleur.

Mais pourquoi le cannabis semble-t-il fonctionner si bien? Le Dr Ethan Russo, directeur médical de PHYTECS, croit que les symptômes à multiples facettes de la fibromyalgie peuvent être causés par une déficience du système endocannabinoïde (ECS) du corps, une maladie qu’il appelle la déficience endocannabinoïde clinique (DEC). Peut-être que la raison pour laquelle le cannabis est si efficace est qu’il suffit de compléter ce dont le corps a besoin – de la même façon que les gens prennent un supplément pour traiter la carence en vitamine D ou B12.

Russo explore les preuves de son hypothèse dans un prochain article intitulé “Déficit clinique endocannabinoïde reconsidéré: la recherche actuelle soutient la théorie de la migraine, de la fibromyalgie, de l’intestin irritable et d’autres syndromes résistants au traitement”. Son idée reste théorique , il y a quelques recherches tôt indiquant qu’il peut être sur quelque chose.

L’ECS est composé de récepteurs de cannabinoïdes dans le cerveau, la moelle épinière, les nerfs, l’intestin, les organes et d’autres endroits dans le corps. Il aide le corps à maintenir son homéostasie et participe à un certain nombre de processus physiologiques, notamment la sensation de douleur, l’humeur, la mémoire et l’appétit, entre autres. Le corps fabrique naturellement des endocannabinoïdes – les mêmes types d’endocannabinoïdes que le cannabis – qui nourrissent le système ECS et le maintiennent en bon état.

La fibromyalgie provoque des symptômes dans tout le corps, les principaux étant la douleur, la fatigue, les troubles cognitifs et le sommeil. Certaines conditions, comme le syndrome du côlon irritable (IBS) et la migraine, sont extrêmement fréquentes chez les personnes atteintes de fibromyalgie – à tel point que Russo croit qu’elles peuvent toutes être liées à une déficience ECS.

Sa théorie a un sens. L’ECS joue un rôle dans tant de systèmes majeurs de l’organisme, donc s’il fonctionnait effectivement mal, cela expliquerait pourquoi les personnes atteintes de fibrome ont des symptômes aussi variés. Compléter l’ECS avec des cannabinoïdes de la plante de cannabis soulagerait théoriquement les symptômes parce que la carence est traitée.

Russo a d’abord émis l’hypothèse que la fibromyalgie, le SCI et la migraine pourraient être causés par une déficience ECS en 2001. (Cliquez ici pour lire sa première critique sur le sujet.) Son dernier article fait le point sur une nouvelle recherche soutenant la carence en ECS. pour la fibromyalgie, le SCI et la migraine.

“D’autres études ont fourni une base plus solide pour la théorie”, écrit-il, “tandis que les données cliniques ont également démontré une diminution de la douleur, une amélioration du sommeil et d’autres bénéfices pour le traitement cannabinoïde.

Le DEC repose sur le principe que de nombreux troubles cérébraux ont été associés à des déficiences neurotransmetteurs. Par exemple, la dopamine a été impliquée dans la maladie de Parkinson, et la sérotonine et la noradrénaline ont été associées à la dépression.

“Si la fonction endocannabinoïde était diminuée, il s’ensuivrait qu’un seuil de douleur abaissé serait opérationnel, avec des dérangements de digestion, d’humeur et de sommeil parmi les systèmes physiologiques presque universels sous-servis par l’ECS”, écrit Russo.

C’est une bouchée, mais essentiellement cela signifie que si l’ECS ne fonctionne pas correctement, alors il pourrait expliquer la douleur, le sommeil, les problèmes digestifs et autres si fréquents chez les patients atteints de fibromyalgie. L’ajout de cannabinoïdes à l’organisme grâce à l’usage du cannabis peut contribuer à rétablir l’équilibre du système ECS.

“C’est une clé dans une serrure dans votre corps qui existe pour une raison”, explique le Dr Jahan Marcu, scientifique en chef à Americans for Safe Access. “Nous envoyons des cannabinoïdes pour activer ce système qui est supposé fonctionner. C’est une sorte de soin et d’alimentation de l’ECS pour qu’il puisse faire son travail. ”

La meilleure preuve de DEC provient d’une étude italienne sur la migraine, qui a révélé des niveaux réduits d’un endocannabinoïde connu sous le nom d’anandamide chez les patients souffrant de migraines chroniques par rapport aux contrôles sains.

“Les niveaux réduits de [anandamide] dans le liquide céphalorachidien des patients migraineux chroniques soutiennent l’hypothèse de l’échec de ce système cannabinoïde endogène dans la migraine chronique”, a lu l’étude.

Malheureusement, l’étude italienne ne sera probablement jamais répétée aux Etats-Unis car elle nécessite des ponctions lombaires risquées et invasives.

Dans l’intestin, l’ECS module le mouvement des aliments le long du tube digestif, la libération des sucs digestifs pour décomposer la nourriture et l’inflammation.

Le cannabis a longtemps été utilisé pour traiter les problèmes digestifs et a été l’un des premiers traitements efficaces contre la diarrhée causée par le choléra au 19ème siècle.

“Malheureusement, alors que de nombreux sondages auprès des patients ont vanté les bienfaits du traitement des symptômes du SII par les cannabinoïdes, et qu’un soutien anecdotique abondant est évident sur Internet, peu de travail clinique a été accompli”, écrit Russo.

Quelques études utilisant la marijuana pour la fibromyalgie ont eu des résultats positifs. Dans l’ensemble, la marijuana réduit la douleur et l’anxiété et améliore le sommeil et le bien-être général.

“Il y a effectivement des preuves que les niveaux d’au moins un endocannabinoïde (anandamide) augmentent dans la circulation des patients atteints de fibromyalgie”, explique le professeur Roger G. Pertwee de l’Université d’Aberdeen en Ecosse. “Il existe également des preuves considérables que l’anandamide est souvent libéré d’une manière qui réduit les symptômes indésirables tels que la douleur et la spasticité dans certains troubles. … Il est généralement admis que le THC, principal constituant psychoactif du cannabis, peut soulager la douleur, y compris la douleur neuropathique par exemple, en activant directement les récepteurs aux cannabinoïdes. … Certains composants non psychoactifs du cannabis ont également été trouvés pour soulager les signes de la douleur, au moins dans les modèles animaux. ”

Pour des preuves anecdotiques, Russo cite le rapport de la National Pain Foundation / National Pain Report dans sa revue, en disant: «Les résultats de l’enquête favorisent fortement le cannabis plutôt que les médicaments d’ordonnance peu efficaces. Ces résultats soutiennent certainement un besoin urgent d’essais contrôlés randomisés plus définitifs d’un médicament à base de cannabis bien formulé et standardisé dans la fibromyalgie, dans la mesure où les médicaments existants avec approbation réglementaire semblent être loin de la réalité.

Plus de recherche doit être faite pour prouver ou réfuter l’existence de DEC.

“Ce dont nous avons vraiment besoin, ce sont des essais contrôlés randomisés pour examiner cela plus attentivement, et c’est le seul type de preuve que la [Food and Drug Administration] et la plupart des médecins vont trouver acceptable à la fin”, dit Russo.

Les IRM et TEP ne sont pas encore en mesure de détecter les taux d’endocannabinoïdes chez les patients vivants, mais à mesure que la technologie progresse, cela peut devenir une possibilité. La possibilité de tester réellement les taux d’endocannabinoïdes chez les patients atteints de fibromyalgie et de comparer ceux-ci avec des témoins sains aiderait à confirmer la théorie de Russo.

“Nous sommes sur le point d’avoir cette capacité”, dit Russo. “C’est dans mes plans de regarder ce genre de chose à l’avenir.”

Source: fedupwithfatigue.com

Loading...

145 thoughts on “Carence en endocanabinoïdes conduit à la fibromyalgie. Enquête nationale sur la douleur

  1. Hey there this is somewhat of off topic but I was
    wondering if blogs use WYSIWYG editors or if you have to
    manually code with HTML. I’m starting a blog soon but have no coding expertise
    so I wanted to get advice from someone with experience.
    Any help would be greatly appreciated!

  2. Somebody necessarily lend a hand to make significantly posts I might state.
    That is the very first time I frequented your web page and up to now?
    I surprised with the research you made to create this particular
    post extraordinary. Great activity!

  3. I do trust all of the ideas you have offered in your post.
    They’re really convincing and will certainly work. Still, the posts are very short for novices.
    May you please extend them a little from subsequent time?
    Thank you for the post.

  4. I have been browsing online more than 3 hours nowadays,
    but I never discovered any attention-grabbing article like yours.

    It is pretty value sufficient for me. In my opinion,
    if all web owners and bloggers made good content as you did, the
    web can be much more useful than ever before.

  5. I really like your blog.. very nice colors & theme.
    Did you make this website yourself or did you hire someone to do it for you?
    Plz answer back as I’m looking to construct my own blog and would like to find out where u got this from.
    cheers

  6. I’m really inspired with your writing skills and also with the layout for your weblog.
    Is this a paid subject matter or did you customize it
    your self? Anyway keep up the nice high quality writing,
    it is rare to peer a great weblog like this one nowadays..

  7. Wow, fantastic blog layout! How long have you been blogging for?
    you made blogging look easy. The overall look of your web site is
    wonderful, let alone the content!

  8. You can definitely see your skills in the work you write.
    The sector hopes for even more passionate writers
    like you who aren’t afraid to say how they believe.
    Always go after your heart.

  9. Excellent post. I was checking constantly this blog and I’m impressed!
    Very useful information specially the last part 🙂 I care for such information much.
    I was looking for this particular info for a long time.
    Thank you and good luck.

  10. I don’t even understand how I finished up right here, but I
    thought this publish was good. I do not understand who you’re however definitely
    you are going to a famous blogger if you aren’t already.

    Cheers!

  11. It is perfect time to make some plans for the future and it is time to be happy.
    I have read this post and if I could I want to suggest
    you some interesting things or advice. Maybe you could write next
    articles referring to this article. I want to read more
    things about it!

  12. Write more, thats all I have to say. Literally, it seems as though you
    relied on the video to make your point. You definitely know what youre talking about, why waste your intelligence on just posting videos to
    your site when you could be giving us something
    informative to read?

  13. I was more than happy to uncover this great site. I need to to thank you for your time for this
    particularly wonderful read!! I definitely really liked every
    bit of it and i also have you saved as a favorite to see new information in your blog.

  14. I loved as much as you will receive carried out right here.
    The sketch is attractive, your authored subject matter stylish.
    nonetheless, you command get bought an edginess over that you wish be delivering the following.
    unwell unquestionably come more formerly again since exactly the same nearly a lot often inside case you shield this hike.

  15. May I just say what a comfort to find a person that genuinely understands what they are
    discussing over the internet. You certainly understand how to bring a problem to light and make it important.
    More people have to check this out and understand this side of your story.
    I was surprised you are not more popular because you
    most certainly have the gift.

  16. You really make it appear really easy together with your presentation however I find this topic to be
    actually one thing which I think I might never understand.
    It kind of feels too complex and very vast for me. I’m looking
    forward in your next put up, I will attempt
    to get the hang of it!

  17. Your style is unique compared to other folks I’ve read stuff from.
    I appreciate you for posting when you have the opportunity,
    Guess I’ll just bookmark this page.

  18. Howdy terrific website! Does running a blog such as this take a
    massive amount work? I’ve virtually no expertise in programming however I had been hoping
    to start my own blog soon. Anyway, if you have any suggestions or tips for new blog owners please share.
    I know this is off topic however I just had to ask.
    Thank you!

  19. I just like the valuable information you provide in your articles.
    I’ll bookmark your weblog and test once more here frequently.

    I am reasonably certain I will be informed a lot of new stuff proper here!
    Good luck for the following!

  20. I’ll right away seize your rss feed as I can not
    to find your email subscription link or newsletter service.
    Do you’ve any? Please permit me recognise so that
    I could subscribe. Thanks.

  21. Great blog you have here but I was wanting
    to know if you knew of any user discussion forums that cover the same topics talked about here?
    I’d really love to be a part of community where I can get advice from other experienced people that share
    the same interest. If you have any suggestions, please let me know.
    Thanks!

  22. Excellent way of explaining, and nice piece of writing
    to take facts about my presentation subject, which i am going to deliver in college.

  23. Hi are using WordPress for your site platform?
    I’m new to the blog world but I’m trying to get started
    and set up my own. Do you require any coding expertise to make your own blog?
    Any help would be greatly appreciated!

  24. Hi there just wanted to give you a quick heads up.
    The words in your article seem to be running off the screen in Firefox.
    I’m not sure if this is a format issue or something
    to do with browser compatibility but I figured I’d post to let you know.

    The design and style look great though! Hope
    you get the issue solved soon. Many thanks

  25. Very nice post. I simply stumbled upon your blog and wished to mention that I have really enjoyed
    browsing your weblog posts. After all I will be subscribing on your feed and I’m hoping you write again very soon!

  26. After I initially left a comment I seem to have clicked on the -Notify me when new comments are added- checkbox
    and from now on whenever a comment is added I recieve
    4 emails with the same comment. Is there a way you can remove me from that service?
    Kudos!

  27. Great beat ! I would like to apprentice whilst you amend your website,
    how can i subscribe for a weblog website?
    The account aided me a applicable deal. I had been a little bit familiar of this your broadcast offered
    vivid clear idea

  28. Hi there everyone, it’s my first go to see at this web site, and paragraph is
    genuinely fruitful designed for me, keep up posting these types of articles or reviews.

  29. Hmm it seems like your site ate my first comment (it was super long) so I guess I’ll just sum it up what I
    had written and say, I’m thoroughly enjoying your blog.

    I as well am an aspiring blog writer but I’m still new to the whole thing.
    Do you have any tips for newbie blog writers?
    I’d definitely appreciate it.

  30. Awesome blog! Is your theme custom made or did you download it from somewhere?
    A theme like yours with a few simple adjustements would really make my blog shine.
    Please let me know where you got your design. Thanks a lot

  31. Hey I know this is off topic but I was wondering if you
    knew of any widgets I could add to my blog that automatically tweet my newest twitter updates.
    I’ve been looking for a plug-in like this for quite some time and was hoping maybe you would have some experience
    with something like this. Please let me know if you run into anything.
    I truly enjoy reading your blog and I look forward to your new updates.

  32. This design is wicked! You definitely know how to keep a reader amused.
    Between your wit and your videos, I was almost moved to start my own blog (well, almost…HaHa!) Wonderful job.
    I really enjoyed what you had to say, and more than that, how you presented it.
    Too cool!

  33. I’d like to thank you for the efforts you’ve put
    in writing this website. I am hoping to see the same high-grade blog
    posts by you later on as well. In truth, your creative writing abilities has encouraged me to get my own, personal site
    now 😉

  34. I have read so many articles or reviews concerning the blogger lovers but this paragraph is genuinely a fastidious piece of writing, keep it up.

  35. This design is spectacular! You most certainly know how to keep a reader amused.

    Between your wit and your videos, I was almost moved to
    start my own blog (well, almost…HaHa!) Wonderful job.
    I really loved what you had to say, and more than that, how you
    presented it. Too cool!

  36. Can I simply just say what a relief to uncover someone that genuinely understands what they
    are discussing on the internet. You actually know how
    to bring a problem to light and make it important.
    More people need to look at this and understand this
    side of your story. I was surprised you aren’t more popular given that you most certainly possess the gift.

  37. Thank you for another informative site. Where else could I get that type of information written in such an ideal means?

    I have a mission that I’m simply now operating on, and I have been on the glance
    out for such information.

  38. Hey there just wanted to give you a brief heads
    up and let you know a few of the images aren’t loading correctly.

    I’m not sure why but I think its a linking issue. I’ve tried it in two different internet browsers and
    both show the same outcome.

  39. Hi just wanted to give you a quick heads up and let you know a few of the images aren’t loading
    correctly. I’m not sure why but I think its a linking issue.

    I’ve tried it in two different internet browsers and both show the same outcome.

  40. Hello there! Do you know if they make any plugins
    to help with Search Engine Optimization? I’m trying to get my blog to rank for some
    targeted keywords but I’m not seeing very good results.
    If you know of any please share. Thank you!

  41. It is appropriate time to make some plans for the future and it is time to
    be happy. I have read this post and if I could I want to suggest you some interesting things or
    advice. Maybe you can write next articles referring to this article.
    I wish to read even more things about it!

  42. Do you mind if I quote a few of your posts as long as I provide
    credit and sources back to your website? My
    blog site is in the exact same niche as yours and my users would definitely benefit from a lot of the information you provide here.
    Please let me know if this alright with you.
    Thanks!

  43. Pretty nice post. I just stumbled upon your weblog and wished to
    say that I’ve really enjoyed browsing your blog posts.
    In any case I will be subscribing to your rss feed and I hope you write again soon!

  44. Do you mind if I quote a few of your posts as long as I
    provide credit and sources back to your website?
    My blog is in the exact same niche as yours and my users would certainly benefit from some
    of the information you provide here. Please let me
    know if this ok with you. Thanks!

  45. Woah! I’m really loving the template/theme of this site.
    It’s simple, yet effective. A lot of times it’s tough to get that
    “perfect balance” between superb usability and appearance.
    I must say you’ve done a awesome job with this.
    Additionally, the blog loads super quick for me on Firefox.
    Excellent Blog!

  46. Attractive section of content. I just stumbled upon your weblog and in accession capital
    to assert that I acquire actually enjoyed account your blog posts.

    Any way I’ll be subscribing to your feeds and even I achievement you
    access consistently rapidly.

  47. First of all I want to say awesome blog! I had a
    quick question in which I’d like to ask if you
    don’t mind. I was interested to find out how you center yourself and clear your thoughts prior to writing.
    I have had difficulty clearing my mind in getting my ideas
    out. I truly do take pleasure in writing however it
    just seems like the first 10 to 15 minutes are wasted
    just trying to figure out how to begin. Any recommendations or hints?
    Cheers!

  48. Greetings! I know this is kinda off topic but I was wondering which blog platform are you using for this site?
    I’m getting sick and tired of WordPress because I’ve had problems with hackers and I’m looking at alternatives for
    another platform. I would be awesome if you could
    point me in the direction of a good platform.

  49. You could certainly see your skills in the article you write.
    The world hopes for even more passionate writers such as
    you who aren’t afraid to mention how they believe.

    All the time follow your heart.

Leave a Reply

Your email address will not be published. Required fields are marked *