How nerve damage plays a role in fibromyalgia. Recent study

By: Lisa Martin

In a recent study of patients suffering from fibromyalgia, almost half of the patients had moderate to severe damage to their skin cells.

Damage to the nerve caused nerve fibers has been considered small fiber polyneuropathy or SFPN. Small fiber polyneuropathy is caused by some specific medical conditions.

Currently, there is no known cause of fibromyalgia, so this discovery of nerve damage could make some progress in finding exactly what causes the disorder.

Fibromyalgia disorders differentiate the patient from the patient, but typical symptoms include chronic widespread pain, extreme fatigue and hypersensitivity to pain and pressure. The disorder disproportionately affects women compared to men.

Looking at nerve damage

Some progress has been made on how to correctly diagnose the disorder, but its pathology remains a mystery. Fibromyalgia has some of the same symptoms as small fiber polyneurotherapy because small fiber polyneurotherapy has caused widespread chronic pain in people who have been diagnosed with it.

The study was conducted on 27 adults with the fibromyalgia disorder and a group of 30 healthy people who had volunteered for the study. The same tests used in the small fiber polyneurotherapy diagnostics were used to evaluate the study participants. The tests included a physical examination and the administration of a questionnaire.

In addition, researches administered skin biopsies help with the evaluation of nerve fibers in the legs of patients and control of blood pressure, sweating and heart rate of patients.

Neuropathy was found in very high counts in patients with fibromyalgia, while the group of healthy individuals seemed normal. Thirteen of the 27 patients with fibromyalgia were recorded as individuals with reduced levels of nerve fiber density in the skin.

Those about thirteen people also had strange results from the autonomous function test. Due to these results, it was presumed that these thirteen individuals had small fiber polyneurotherapy.

While the conclusions drawn from this test do not suggest a cause in the development of all conditions of fibromyalgia, it does provide researchers with some evidence on what causes fibromyalgia in at least some patients.

Fibromyalgia disorder is a very complex, unique and complex disorder. Its symptoms and severity are different in each patient it affects. Due to this unique differentiation, there is not a single explanation for the development of fibromyalgia.

This process could take months or years before answers are found about what are the main causes of fibromyalgia. Before you can work on the cure of fibromyalgia, researchers must first find out what exactly causes the disorder in patients.

This study is currently the one of its kind. The results have been published recently so that other laboratories will soon start to create their own tests and experiments according to the model that this study has elaborated.

Some may already have started with some adaptations. The search for a better diagnosis of fibromyalgia is continuous.

And finding better treatments for those people who have been inflicted by the fibromyalgia disorder is one of the top priorities when it comes to this unique disorder.

Evidence of nerve damage in approximately half of patients with fibromyalgia

Summary: About half of a small group of patients with fibromyalgia, a common syndrome that causes chronic pain and other symptoms, was found to have nerve fiber damage to the skin and other evidence of a disease called small-fiber polyneuropathy (SFPN). ). Unlike fibromyalgia, SFPN has a clear pathology and is known to be caused by specific medical conditions, some of which can be treated and sometimes cured.

About half of a small group of patients with fibromyalgia, a common syndrome that causes chronic pain and other symptoms, was found to have nerve fiber damage to the skin and other evidence of a disease called small fiber polyneuropathy (SFPN). . Unlike fibromyalgia, which has had no known causes and few effective treatments, SFPN has a clear pathology and is known to be caused by specific medical conditions, some of which can be treated and sometimes cured. The study by Massachusetts General Hospital (MGH) researchers will appear in the journal DOLOR and has been published online.

“This provides part of the first objective evidence of a mechanism behind some cases of fibromyalgia, and the identification of an underlying cause is the first step to finding better treatments,” says Anne Louise Oaklander, MD, PhD, director of the Unit Nervous Lesions in the MGH Department of Neurology and corresponding author of the Pain article.

The term fibromyalgia describes a series of symptoms, including chronic widespread pain, increased sensitivity to pressure and fatigue, which is believed to affect 1 to 5 percent of people in Western countries, most often in the women. Although the National Institutes of Health and the American College of Rheumatology have recognized the diagnosis of fibromyalgia, its biological basis remains unknown. Fibromyalgia shares many symptoms with SFPN, a recognized cause of chronic widespread pain for which objective tests are accepted.

Designed to investigate possible connections between the two conditions, the current study enrolled 27 adult patients with fibromyalgia diagnoses and 30 healthy volunteers. Participants went through a battery of tests used to diagnose SFPN, including evaluations of neuropathy based on a physical examination and answers to a questionnaire, skin biopsies to evaluate the number of nerve fibers in the lower legs and tests of autonomic functions , such as heart rate, blood pressure and sweating.

The questionnaires, examination evaluations and skin biopsies found significant levels of neuropathy in patients with fibromyalgia but not in the control group. Of the 27 patients with fibromyalgia, 13 had a marked reduction in nerve fiber density, abnormal autonomic function tests or both, indicating the presence of SFPN. Participants who met the criteria for SFPN also underwent blood tests for known causes of the disorder, and although none of them had results suggestive of diabetes, a common cause of SFPN, two were found to be infected with the hepatitis virus. C, which can be treated successfully. and more than half had evidence of some type of immune system dysfunction.

“Until now, there has not been a good idea about what causes fibromyalgia, but now we have evidence for some, but not for all patients.” Fibromyalgia is too complex for a ‘one size fits all’ explanation, “says Oaklander, an associate professor of neurology at Harvard Medical School. “The next step of independent confirmation of our findings from other laboratories is already happening, and we must also follow those patients who did not meet the SFPN criteria to see if we can find other causes. Helping any of these people to receive definitive diagnoses and better treatment would be a great achievement. “

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