Cómo el daño nervioso juega un papel en la fibromialgia. Estudio reciente

En un estudio reciente de pacientes que padecen fibromialgia, casi la mitad de los pacientes tenían daño moderado a severo en sus células de la piel.

El daño al nervio causado a las fibras nerviosas se ha considerado polineuropatía de fibra pequeña o SFPN. La polineuropatía de fibras pequeñas es causada por algunas condiciones médicas específicas.

Actualmente, no hay una causa conocida de fibromialgia, por lo que este descubrimiento de daño nervioso podría hacer algunos avances en la búsqueda de lo que causa exactamente el trastorno.

Los trastornos de fibromialgia diferencian al paciente del paciente, pero los síntomas típicos incluyen dolor crónico generalizado, fatiga extrema e hipersensibilidad al dolor y la presión. El trastorno afecta desproporcionadamente a las mujeres en comparación con los hombres.

Mirando el daño al nervio

Se han realizado algunos avances sobre cómo diagnosticar correctamente el trastorno, pero su patología sigue siendo un misterio. La fibromialgia tiene algunos de los mismos síntomas que la polineuroterapia de fibra pequeña porque la polineuroterapia de fibra pequeña ha causado un dolor crónico generalizado en las personas que han sido diagnosticadas con esta.

El estudio se realizó en 27 adultos con el trastorno de la fibromialgia y un grupo de 30 personas sanas que se habían ofrecido como voluntarios para el estudio. Las mismas pruebas que se utilizan en los diagnósticos de polineuroterapia de fibra pequeña se utilizaron para evaluar a los participantes del estudio. Las pruebas incluyeron un examen físico y la administración de un cuestionario.

Además, las investigaciones administradas biopsias de piel la ayuda con la evaluación de las fibras nerviosas en las piernas de los pacientes y el control de la presión arterial, sudoración y la frecuencia cardíaca de los pacientes.

La neuropatía se encontró en recuentos muy altos en los pacientes con fibromialgia, mientras que el grupo de individuos sanos parecía normal. Trece de los 27 pacientes con fibromialgia se registraron como individuos con niveles reducidos de densidad de fibras nerviosas en la piel.

Esas unas trece personas también tenían extraños resultados de la prueba de función autónoma. Debido a estos resultados, se presumió que estos trece individuos tenían polineuroterapia de fibra pequeña.

Si bien las conclusiones extraídas de esta prueba no sugieren una causa en el desarrollo de todas las condiciones de la fibromialgia, sí proporciona a los investigadores alguna evidencia sobre qué causa la fibromialgia en al menos algunos pacientes.

El trastorno de la fibromialgia es un trastorno muy complejo, único y complejo. Sus síntomas y severidad son diferentes en cada paciente que afecta. Debido a esta diferenciación única, no hay una sola explicación para el desarrollo de la fibromialgia.

Este proceso podría llevar meses o años antes de que se encuentren las respuestas sobre cuáles son las principales causas de la fibromialgia. Antes de que se pueda trabajar en la cura de la fibromialgia, los investigadores primero deben encontrar qué causa exactamente el trastorno en los pacientes.

Este estudio es actualmente el de su tipo. Los resultados se han publicado recientemente para que otros laboratorios comiencen pronto a crear sus propias pruebas y experimentos de acuerdo con el modelo que este estudio ha elaborado.

Algunos ya pueden haber comenzado con algunas adaptaciones. La búsqueda de un mejor diagnóstico de fibromialgia es continua.

Y encontrar mejores tratamientos para aquellas personas que han sido infligidas por el trastorno de la fibromialgia es una de las principales prioridades cuando se trata de este trastorno único.

Evidencia de daño nervioso en aproximadamente la mitad de los pacientes con fibromialgia

Resumen: aproximadamente la mitad de un pequeño grupo de pacientes con fibromialgia, un síndrome común que causa dolor crónico y otros síntomas, se encontró que tenía daño en las fibras nerviosas de la piel y otra evidencia de una enfermedad llamada polineuropatía de fibras pequeñas (SFPN). A diferencia de la fibromialgia, la SFPN tiene una patología clara y se sabe que es causada por afecciones médicas específicas, algunas de las cuales pueden tratarse y en ocasiones curarse.

Alrededor de la mitad de un pequeño grupo de pacientes con fibromialgia, un síndrome común que causa dolor crónico y otros síntomas, se encontró que tenía daño en las fibras nerviosas de la piel y otra evidencia de una enfermedad llamada polineuropatía de fibras pequeñas (SFPN). A diferencia de la fibromialgia, que no ha tenido causas conocidas y pocos tratamientos efectivos, SFPN tiene una patología clara y se sabe que es causada por afecciones médicas específicas, algunas de las cuales pueden tratarse y en ocasiones curarse. El estudio de los investigadores del Hospital General de Massachusetts (MGH) aparecerá en la revista DOLOR y se ha publicado en línea.

“Esto proporciona parte de la primera evidencia objetiva de un mecanismo detrás de algunos casos de fibromialgia, y la identificación de una causa subyacente es el primer paso para encontrar mejores tratamientos”, dice Anne Louise Oaklander, MD, PhD, directora de la Unidad de Lesiones Nerviosas en el MGH Department of Neurology y autor correspondiente del artículo de Pain.

El término fibromialgia describe una serie de síntomas, que incluyen dolor crónico generalizado, aumento de la sensibilidad a la presión y la fatiga, que se cree que afectan al 1 al 5 por ciento de las personas en los países occidentales, con mayor frecuencia en las mujeres. Aunque los Institutos Nacionales de Salud y el Colegio Estadounidense de Reumatología han reconocido el diagnóstico de fibromialgia, su base biológica sigue siendo desconocida. La fibromialgia comparte muchos síntomas con SFPN, una causa reconocida de dolor crónico generalizado para el cual se aceptan pruebas objetivas.

Diseñado para investigar posibles conexiones entre las dos afecciones, el estudio actual inscribió a 27 pacientes adultos con diagnósticos de fibromialgia y 30 voluntarios sanos. Los participantes pasaron por una batería de pruebas utilizadas para diagnosticar SFPN, incluidas evaluaciones de neuropatía basadas en un examen físico y respuestas a un cuestionario, biopsias de piel para evaluar el número de fibras nerviosas en la parte inferior de las piernas y pruebas de funciones autonómicas, como frecuencia cardíaca , presión arterial y sudoración.

Los cuestionarios, evaluaciones de exámenes y biopsias de piel encontraron niveles significativos de neuropatía en pacientes con fibromialgia pero no en el grupo de control. De los 27 pacientes con fibromialgia, 13 tuvieron una reducción marcada en la densidad de la fibra nerviosa, pruebas de función autonómica anormal o ambas, lo que indica la presencia de SFPN. Los participantes que cumplieron los criterios para SFPN también se sometieron a análisis de sangre por causas conocidas del trastorno, y aunque ninguno de ellos tuvo resultados sugestivos de diabetes, una causa común de SFPN, se encontró que dos tenían infección por el virus de la hepatitis C, que puede tratarse con éxito. y más de la mitad tenía evidencia de algún tipo de disfunción del sistema inmune.

“Hasta ahora, no ha habido una buena idea sobre qué causa la fibromialgia, pero ahora tenemos evidencia para algunos, pero no para todos los pacientes”. La fibromialgia es demasiado compleja para una explicación ‘de talla única’ “, dice Oaklander, profesor asociado de Neurología en la Facultad de Medicina de Harvard. “El siguiente paso de confirmación independiente de nuestros hallazgos de otros laboratorios ya está ocurriendo, y también debemos seguir a aquellos pacientes que no cumplieron con los criterios de SFPN para ver si podemos encontrar otras causas. Ayudar a cualquiera de estas personas a recibir diagnósticos definitivos y un mejor tratamiento sería un gran logro “.

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