Nouveau vaccin pour le traitement de la fibromyalgie qui fonctionne réellement. Doit lire

Si quelqu’un pourrait vous donner un vaccin qui permettrait de guérir la fibromyalgie, le feriez – vous? Cela peut sembler comme un rêve, mais il est plus proche de la réalité que vous pourriez penser. Basée à Los Angeles entreprise biomédicale   Genetics Epic  chercheurs et Massachusetts General Hospital cherchent l’ approbation de la Food and Drug Administration (FDA) pour un essai clinique de l’ année prochaine pour tester   le bacille de Calmette-Guérin (BCG)   vaccin comme traitement potentiel pour la fibromyalgie .

Le BCG est un vaccin contre la tuberculose générique, qui est près de 100 ans et a été administré en toute sécurité des millions de fois « , a déclaré le Dr Denise Faustman, chef du laboratoire Faustman au Massachusetts General Hospital. « Depuis plus de 10 ans, notre groupe de recherche au Massachusetts General Hospital enquêtent activement sur le rôle que pourrait jouer le vaccin BCG dans le traitement de diverses formes d’auto-immunité. Notre objectif actuel est le diabète de type 1, mais aussi dans le monde entier par le BCG testé dans un certain nombre de maladies auto-immunes. Au cours des deux prochaines années, nous allons commencer les essais cliniques de BCG dans la fibromyalgie ».

Selon l’Organisation mondiale de la Santé, plus de 100 millions d’enfants étant donné le vaccin BCG chaque année. Il est principalement utilisé dans les pays en développement où la tuberculose est toujours active. Le vaccin BCG n’est pas disponible aux États-Unis en raison du faible risque d’infection. Aux États-Unis, le BCG est utilisé dans un petit nombre de patients pour le traitement du cancer de la vessie.

Alors, demandez l’évidence est la raison pour laquelle un vaccin pour une maladie pulmonaire contagieuse sont utilisés pour la fibromyalgie? La réponse se trouve dans le système immunitaire.

Les vaccins sont généralement administrés aux personnes en bonne santé pour prévenir l’infection. Dans ce cas, toutefois, le vaccin BCG administré à des patients atteints de fibromyalgie dans une tentative de supprimer leurs symptômes.

 

Lorsque Epic Genetics a été chargé de créer un test de diagnostic de la fibromyalgie il y a plusieurs années, les chercheurs ont couru toutes sortes de tests de laboratoire pour les patients atteints de fibromyalgie pour savoir comment ils diffèrent des contrôles sains et quelle est la cause possible de leurs symptômes. Les chercheurs ont découvert une anomalie des globules blancs chez les patients atteints de fibromyalgie, ce qui leur permet de se connecter les symptômes associés à un déficit immunitaire.

Résultats d'images pour le nouveau vaccin pour le traitement de la fibromyalgie qui lisent réellement work.Must

« Nous pensons que [le terme] La fibromyalgie est un abus de langage », a déclaré le Dr Bruce Gillis, chef de la direction Epic Genetics. « Ces gens ne souffrent pas de tout ce qui affecte les muscles, par exemple. Ce qu’ils souffrent est leur système immunitaire ne peut pas avoir des quantités normales de protéines protectrices. … Il y a des cellules appelées cellules mononucléaires du sang périphérique dans le système immunitaire. Ils ne sont pas la production de quantités normales des protéines protectrices appelées chimiokines et cytokines ».

La découverte a conduit à l’élaboration du test FM / sang pour la fibromyalgie. (Oui, malgré ce que votre médecin peut-être dit, il y a un test sanguin pour la fibromyalgie! Il est tout simplement pas largement acceptée dans la communauté médicale.) Le test analyse les niveaux de quatre chimiokines et cytokines trouvés à des niveaux plus faibles chez les patients atteints de fibromyalgie . Ces quatre chimiokines et cytokines par hasard les mêmes que celles qui sont amplifiés par le vaccin BCG.

« Compte tenu de ce qui est publié dans la littérature médicale, nous croyons que ce vaccin ne sera pas affecter le système immunitaire retour [fibromyalgie] », a dit Gillis.

Gilles et Faustman cherchent l’approbation de la FDA pour les premiers vaccins BCG pour gérer les patients de fibromyalgie début de l’année prochaine.

« Ceci est la première fois qu’un traitement direct de la fibromyalgie se produira », a dit Gillis. « Comme vous le savez, le médicament [actuellement sur le marché] pour la fibromyalgie simplement traiter les symptômes. Ils ne sont pas des avantages du système immunitaire. [Sociétés pharmaceutiques] à admettre qu’ils ne traitent que les symptômes, mais vous devez traiter la maladie, et c’est pourquoi nous allons de l’avant avec l’application du vaccin [FDA] “.

Résultats d'images pour le nouveau vaccin pour le traitement de la fibromyalgie qui lisent réellement work.Must

Si la théorie Gillis est vrai, alors les « chimiokines et cytokines chez les patients atteints de fibromyalgie sont déficients seront plus déficients [dès que le vaccin BCG est administré] « , selon Gillis. « Les niveaux de production normaliseront, et vous devez alors supposer que leurs symptômes disparaissent. … Nous pensons que nous sommes sur le point de quelque chose de grand ».

Parce que le vaccin a une longue histoire, il ne devrait pas entraîner des effets secondaires graves chez les patients.

 

Le vaccin BCG devrait coûter $ 20- $ 25 par dose – un montant nominal par rapport aux coûts actuels de la prise de médicaments tous les jours.

« Nous pensons avoir un patient de la fibromyalgie, il faudrait un maximum d’une ou deux doses, afin que vous puissiez comprendre pourquoi je ne reçois pas beaucoup de soutien des compagnies pharmaceutiques », a déclaré Gillis.

En plus de l’essai vaccinal, la génétique Epic collabore avec l’Université de Californie, Los Angeles (UCLA) et l’Université de l’Illinois College of Medicine à Chicago pour séquencer les génomes de 250 000 aux patients atteints de fibromyalgie.

« Nous sommes à la recherche de tout type de modèles génétiques ou des anomalies, ou mutations, » dit Gillis.

Les patients dont le test est positif pour la fibromyalgie avec FM / test sera en mesure de participer à l’étude génomique.

FM / test coûte actuellement 936 $, mais il est couvert par certaines compagnies d’assurance et l’ assurance – maladie. L’équipe de soutien de la génétique Epic aide les patients à déterminer si leur assurance couvrira l’épreuve. Un plan de paiement sans intérêt est disponible pour les personnes qui ne sont pas assurés ou dont l’ assurance ne couvre pas le test.

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